Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2019

17-05-2019 | Original Paper

Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?

Auteurs: Daniel Berends, Cheryl Dissanayake, Lauren P. Lawson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2019

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Previous research has found multiplex (MPX) children have an advantage in cognition compared to simplex (SPX) children. However, MPX parent’s previous experience with older diagnosed siblings has not been considered. We used a large database sample to investigate the MPX advantage and contribution of birth order. Children from the Autism Genetic Resource Exchange (AGRE) were stratified into first- (MPX1, n  = 152) and second-affected MPX (MPX2, n  = 143), SPX (n  = 111), and only-child SPX (SPXOC, n  = 23) groups. Both MPX groups had higher cognitive scores compared to SPX groups, with no differences between MPX1 and MPX2 groups. No differences were found for autism symptoms or adaptive behaviour. These results suggest parent experience due to birth order is an unlikely contributor to the MPX cognitive advantage.
Literatuur
go back to reference Folstein, S. E., & Rosen-Sheidley, B. (2001). Genetics of autism: Complex aetiology for a heterogeneous disorder. Nature Reviews Genetics, 2(12), 943. CrossRefPubMed Folstein, S. E., & Rosen-Sheidley, B. (2001). Genetics of autism: Complex aetiology for a heterogeneous disorder. Nature Reviews Genetics, 2(12), 943. CrossRefPubMed
go back to reference Lord, C. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles: Western Psychological Services. Lord, C. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles: Western Psychological Services.
go back to reference Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule: ADOS manual. Los Angeles: Western Psychological Services. Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule: ADOS manual. Los Angeles: Western Psychological Services.
go back to reference Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service. Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.
go back to reference Pandey, J. (2008). The Modified Checklist for Autism in Toddlers (M-CHAT) sibling study: Are younger siblings representative of the general ASD population?. Storrs, CT: University of Connecticut. Pandey, J. (2008). The Modified Checklist for Autism in Toddlers (M-CHAT) sibling study: Are younger siblings representative of the general ASD population?. Storrs, CT: University of Connecticut.
go back to reference Roid, G. H. (2003). Stanford–Binet intelligence scales, fifth edition: Technical manual. Itasca, IL: Riverside Publishing. Roid, G. H. (2003). Stanford–Binet intelligence scales, fifth edition: Technical manual. Itasca, IL: Riverside Publishing.
go back to reference Sparrow, S. S., Balla, D. A., & Cicchetti, D. (1984). Vineland adaptive behaviour scales. Circle Pines, MN: American Guidance Service. Sparrow, S. S., Balla, D. A., & Cicchetti, D. (1984). Vineland adaptive behaviour scales. Circle Pines, MN: American Guidance Service.
go back to reference Virkud, Y. V., Todd, R. D., Abbacchi, A. M., Zhang, Y., & Constantino, J. N. (2009). Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 150B(3), 328. https://​doi.​org/​10.​1002/​ajmg.​b.​30810. CrossRef Virkud, Y. V., Todd, R. D., Abbacchi, A. M., Zhang, Y., & Constantino, J. N. (2009). Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 150B(3), 328. https://​doi.​org/​10.​1002/​ajmg.​b.​30810. CrossRef
Metagegevens
Titel
Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?
Auteurs
Daniel Berends
Cheryl Dissanayake
Lauren P. Lawson
Publicatiedatum
17-05-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04052-7