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30-08-2015 | Original Article

Diagnostic and Symptom-Based Predictors of Emotional Processing in Generalized Anxiety Disorder and Major Depressive Disorder: An Event-Related Potential Study

Auteurs: Annmarie MacNamara, Roman Kotov, Greg Hajcak

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 3/2016

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Abstract

The delineation of specific versus overlapping mechanisms in generalized anxiety disorder (GAD) and major depressive disorder (MDD) could shed light on the integrity of these diagnostic categories. For example, negative emotion generation is one mechanism that may be especially relevant to both disorders. Emotional processing abnormalities were examined among 97 outpatients with GAD or MDD and 25 healthy adults, using the late positive potential (LPP), an event-related potential that is larger for emotional versus neutral stimuli. GAD and MDD were also assessed dimensionally across all participants. Both MDD diagnosis and dimensional depression scores were associated with reduced ΔLPP. When controlling for MDD diagnosis/dimension, both the diagnosis and dimension of GAD were associated with increased ΔLPP. Both MDD and GAD dimensions, but not diagnoses, were associated with increased ΔRT to targets that followed emotional pictures. Therefore, MDD and GAD have distinguishable and opposing features evident in neural measures of emotion processing.
Voetnoten
1
IAPS pictures were: unpleasant—1050, 1120, 1275, 1300, 1302, 1930, 1932, 2120, 2811, 2810, 3030, 3051, 3060, 3100, 3102, 3120, 3140, 3160, 3170, 3225, 3400, 3550, 6190, 6200, 6250, 6260, 6313, 6315, 6350, 6370, 6510, 6540, 6560, 6570, 9040, 9253, 9301, 9320, 9405, 9594 and neutral—1450, 1670, 2102, 2190, 2191, 2200, 2214, 2305, 2357, 2383, 2397, 2512, 2745, 5530, 5534, 6150, 7000, 7002, 7004, 7009, 7030, 7034, 7037, 7040, 7054, 7057, 7080, 7130, 7140, 7175, 7491, 7493, 7500, 7546, 7547, 7550, 7560, 7595, 7620, 7920.
 
2
Addition of the following variables did not substantially alter results: (a) interaction terms for GAD × MDD diagnoses and IMAS Generalized Anxiety × IMAS Depression; (b) medication class and (c) other anxiety and depressive diagnostic comorbidities.
 
3
Indeed, Weinberg and Hajcak (2011) found evidence of an increased early ERP (the P1) to unpleasant stimuli in GAD.
 
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Metagegevens
Titel
Diagnostic and Symptom-Based Predictors of Emotional Processing in Generalized Anxiety Disorder and Major Depressive Disorder: An Event-Related Potential Study
Auteurs
Annmarie MacNamara
Roman Kotov
Greg Hajcak
Publicatiedatum
30-08-2015
Uitgeverij
Springer US
Gepubliceerd in
Cognitive Therapy and Research / Uitgave 3/2016
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI
https://doi.org/10.1007/s10608-015-9717-1

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