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30-08-2015 | Original Article

Diagnostic and Symptom-Based Predictors of Emotional Processing in Generalized Anxiety Disorder and Major Depressive Disorder: An Event-Related Potential Study

Auteurs: Annmarie MacNamara, Roman Kotov, Greg Hajcak

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 3/2016

Abstract

The delineation of specific versus overlapping mechanisms in generalized anxiety disorder (GAD) and major depressive disorder (MDD) could shed light on the integrity of these diagnostic categories. For example, negative emotion generation is one mechanism that may be especially relevant to both disorders. Emotional processing abnormalities were examined among 97 outpatients with GAD or MDD and 25 healthy adults, using the late positive potential (LPP), an event-related potential that is larger for emotional versus neutral stimuli. GAD and MDD were also assessed dimensionally across all participants. Both MDD diagnosis and dimensional depression scores were associated with reduced ΔLPP. When controlling for MDD diagnosis/dimension, both the diagnosis and dimension of GAD were associated with increased ΔLPP. Both MDD and GAD dimensions, but not diagnoses, were associated with increased ΔRT to targets that followed emotional pictures. Therefore, MDD and GAD have distinguishable and opposing features evident in neural measures of emotion processing.

vorige artikel Distinct Roles of Emotion Reactivity and Regulation in Depressive and Manic Symptoms Among Euthymic Patients

volgende artikel Impact of Comorbid Depressive Disorders on Subjective and Physiological Responses to Emotion in Generalized Anxiety Disorder

IAPS pictures were: unpleasant—1050, 1120, 1275, 1300, 1302, 1930, 1932, 2120, 2811, 2810, 3030, 3051, 3060, 3100, 3102, 3120, 3140, 3160, 3170, 3225, 3400, 3550, 6190, 6200, 6250, 6260, 6313, 6315, 6350, 6370, 6510, 6540, 6560, 6570, 9040, 9253, 9301, 9320, 9405, 9594 and neutral—1450, 1670, 2102, 2190, 2191, 2200, 2214, 2305, 2357, 2383, 2397, 2512, 2745, 5530, 5534, 6150, 7000, 7002, 7004, 7009, 7030, 7034, 7037, 7040, 7054, 7057, 7080, 7130, 7140, 7175, 7491, 7493, 7500, 7546, 7547, 7550, 7560, 7595, 7620, 7920.

Addition of the following variables did not substantially alter results: (a) interaction terms for GAD × MDD diagnoses and IMAS Generalized Anxiety × IMAS Depression; (b) medication class and (c) other anxiety and depressive diagnostic comorbidities.

Indeed, Weinberg and Hajcak (2011) found evidence of an increased early ERP (the P1) to unpleasant stimuli in GAD.

Andrews, G., Hobbs, M. J., Borkovec, T. D., Beesdo, K., Craske, M. G., Heimberg, R. G., et al. (2010). Generalized worry disorder: A review of DSM-IV generalized anxiety disorder and options for DSM-V. Depression and Anxiety, 27(2), 134–147. doi:10.1002/da.20658.CrossRefPubMed

APA. (2000). Diagnostic and statistical manual of mental disorders IV-TR (4, text rev ed.). Washington, DC: American Psychiatric Publishung Inc.

Beck, A. T. (1976). Cognitive therapy and the emotional disorders. New York: International Universities Press.

Becker, E. S., Rinck, M., Margraf, J., & Roth, W. T. (2001). The emotional Stroop effect in anxiety disorders: General emotional or disorder specificity? Journal of Anxiety Disorders, 15(3), 147–159.CrossRefPubMed

Beesdo, K., Lau, J. Y. F., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., et al. (2009). Common and distinct amygdala-function perturbations in depressed vs. anxious adolescents. Archives of General Psychiatry, 66(3), 275–285. doi:10.1001/archgenpsychiatry.2008.545.CrossRefPubMedPubMedCentral

Bower, G. H. (1981). Mood and memory. American Psychologist, 36, 129–148.CrossRefPubMed

Bradley, M. M. (2009). Natural selective attention: Orienting and emotion. Psychophysiology, 46(1), 1–11. doi:10.1111/j.1469-8986.2008.00702.x.CrossRefPubMedPubMedCentral

Bradley, B. P., Mogg, K., & Lee, S. C. (1997). Attentional biases for negative information in induced and naturally occurring dysphoria. Behaviour Research and Therapy, 35, 911–927.CrossRefPubMed

Bradley, B. P., Mogg, K., Millar, N., & White, J. (1995). Selective processing of negative information: Effects of clinical anxiety, concurrent depression, and awareness. Journal of Abnormal Psychology, 104, 532–536.CrossRefPubMed

Brown, T. A., Campbell, L. A., Lehman, C. L., Grisham, J. R., & Mancill, R. B. (2001). Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. Journal of Abnormal Psychology, 110, 585–599.CrossRefPubMed

Brown, T. A., Chorpita, B. F., & Barlow, D. H. (1998). Structural relationships among dimensions of the DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal. Journal of Abnormal Psychology, 107(2), 179–192.CrossRefPubMed

Bylsma, L. M., Morris, B. H., & Rottenberg, J. (2007). A meta-analysis of emotional reactivity in major depressive disorder. Clinical Psychology Review, 28, 676–691.CrossRefPubMed

Chelminski, I., & Zimmerman, M. (2003). Pathological worry in depressed and anxious patients. Journal of Anxiety Disorders, 17, 533–546.CrossRefPubMed

Chen, J., Wang, Z., Wu, Y., Cai, Y., Shen, Y., Wang, L., & Shi, S. (2013). Differential attentional bias in generalized anxiety disorder and panic disorder. Neuropsychiatric Disease and Treatment, 9, 73–80. doi:10.2147/NDT.S36822.CrossRefPubMedPubMedCentral

Cheng, D. T., Richards, J., & Helmstetter, F. J. (2007). Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock. Learning and Memory, 14(7), 485–490. doi:10.1101/lm.632007.CrossRefPubMedPubMedCentral

Clark, L. A., & Watson, D. (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxonomic implications. Journal of Abnormal Psychology, 100, 316–336.CrossRefPubMed

Codispoti, M., Ferrari, V., & Bradley, M. M. (2007). Repetition and event-related potentials: Distinguishing early and late processes in affective picture perception. Journal of Cognitive Neuroscience, 19, 577–586.CrossRefPubMed

Cronbach, L. J., & Furby, L. (1970). How we should measure “change”: Or should we? Psychological Bulletin, 74(1), 68–80. doi:10.1037/h0029382.CrossRef

Cuthbert, B. N. (2014). Translating intermediate phenotypes to psychopathology: The NIMH Research Domain Criteria. Psychophysiology, 51(12), 1205–1206. doi:10.1111/psyp.12342.CrossRefPubMed

Cuthbert, B. N., Schupp, H. T., Bradley, M. M., Birbaumer, N., & Lang, P. J. (2000). Brain potentials in affective picture processing: Covariation with autonomic arousal and affective report. Biological Psychology, 52, 95–111. doi:10.1016/S0301-0511(99)00044-7.CrossRefPubMed

Dichter, G. S., & Tomarken, A. J. (2008). The chronometry of affective startle modulation in unipolar depression. Journal of Abnormal Psychology, 117(1), 1–15. doi:10.1037/0021-843X.117.1.1.CrossRefPubMedPubMedCentral

Dichter, G. S., Tomarken, A. J., Shelton, R. C., & Sutton, S. K. (2004). Early- and late-onset startle modulation in unipolar depression. Psychophysiology, 41, 433–440.CrossRefPubMed

Diener, C., Kuehner, C., Brusniak, W., Ubl, B., Wessa, M., & Flor, H. (2012). A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression. Neuroimage, 61, 677–685.CrossRefPubMed

Dillon, D. G., Cooper, J. J., Grent, T., Woldoff, M. G., & LaBar, K. S. (2006). Dissociation of event-related potentials indexing arousal and semantic cohesion during emotional word encoding. Brain and Cognition, 62, 43–57.CrossRefPubMed

Dubois, P. H. (1957). Multivariate correlational analysis (Vol. xv). Oxford: Harper.

Dugas, M. J., Buhr, K., & Ladouceur, R. (2004). The role of intolerance of uncertainty in etiology and maintenance. In R. G. Heimberg, C. L. Turk, & D. S. Mennin (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 142–163). New York: Guilford Press.

Etkin, A., & Schatzberg, A. F. (2011). Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. American Journal of Psychiatry, 168, 968–978.CrossRefPubMed

Fava, M., Rankin, M. A., Wright, E. C., Alpert, J. E., Nierenberg, A. A., Pava, J., & Rosenbaum, J. F. (2000). Anxiety disorders in major depression. Comprehensive Psychiatry, 41, 97–102.CrossRefPubMed

First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2007). Structured Clinical Interview for DSM-IV-TR axis I disorders research version, patient edition with psychotic screen. New York: Biometrics Research, New York State Psychiatric Institute.

Foti, D., Hajcak, G., & Dien, J. (2009). Differentiating neural responses to emotional pictures: Evidence from temporal–spatial PCA. Psychophysiology, 46, 521–530. doi:10.1111/j.1469-8986.2009.00796.x.CrossRefPubMed

Foti, D., Olvet, D. M., Klein, D. N., & Hajcak, G. (2010). Reduced electrocortical response to threatening faces in major depressive disorder. Depression and Anxiety, 27, 813–820.CrossRefPubMed

Gehricke, J.-G., & Shapiro, D. (2000). Reduced facial expression and social context in major depression: discrepancies between facial muscle activity and self-reported emotion. Psychiatry Research, 95(2), 157–167. doi:10.1016/S0165-1781(00)00168-2.CrossRefPubMed

Gorman, J. M. (2002). Treatment of generalized anxiety disorder. Journal of Clinical Psychiatry, 63(Suppl 8), 17–23.PubMed

Grasso, D. J., & Simons, R. F. (2011). Perceived parental support predicts enhanced late positive event-related brain potentials to parent faces. Biological Psychology, 86, 26–30. doi:10.1016/j.biopsycho.2010.10.002.CrossRefPubMed

Groenewold, N. A., Opmeer, E. M., de Jonge, P., Aleman, A., & Costafreda, S. G. (2012). Emotional valence modulates brain functional abnormalities in depression: Evidence from a meta-analysis of fMRI studies. Neuroscience and Biobehavioral Reviews.

Hajcak, G., MacNamara, A., & Olvet, D. M. (2010). Event-related potentials, emotion, and emotion regulation: An integrative review. Developmental Neuropsychology, 35, 129–155. doi:10.1080/87565640903526504.CrossRefPubMed

Hamilton, J. P., Etkin, A., Furman, D. J., Lemus, M. G., Johnson, R. F., & Gotlib, I. H. (2012). Functional neuroimaging of major depressive disorder: A meta-analysis and new integration of base line activation and neural response data. The American Journal of Psychiatry, 169(7), 693–703. doi:10.1176/appi.ajp.2012.11071105.CrossRefPubMed

Heller, W., & Nitschke, J. B. (1998). The puzzle of regional brain activity in depression and anxiety: The importance of subtypes and comorbidity. Cognition and Emotion, 12(3), 421–447.CrossRef

Hilbert, K., Lueken, U., & Beesdo-Baum, K. (2014). Neural structures, functioning and connectivity in generalized anxiety disorder and interaction with neuroendocrine systems: A systematic review. Journal of Affective Disorders, 158, 114–126. doi:10.1016/j.jad.2014.01.022.CrossRefPubMed

Kappenman, E. S., Farrens, J. L., Luck, S. J., & Proudfit, G. H. (2014a). Behavioral and ERP measures of attentional bias to threat in the dot-probe task: Poor reliability and lack of correlation with anxiety. Frontiers in Psychology, 5, 1368. doi:10.3389/fpsyg.2014.01368.CrossRefPubMedPubMedCentral

Kappenman, E. S., MacNamara, A., & Proudfit, G. H. (2014b). Electrocortical evidence for rapid allocation of attention to threat in the dot-probe task. Social Cognitive and Affective Neuroscience, 10(4), 577–583. doi:10.1093/scan/nsu098.CrossRefPubMedPubMedCentral

Kayser, J., Bruder, G. E., Tenke, C. E., Stewart, J. E., & Quitkin, F. M. (2000). Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: Differences between depressed patients and healthy adults in P3 amplitude and asymmetry. International Journal of Psychophysiology, 36, 211–236.CrossRefPubMed

Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1992). Generalized anxiety disorder in women: a population-based twin study. Archives of General Psychiatry, 49, 267–272.CrossRefPubMed

Kerr, N., Scott, J., & Phillips, M. L. (2005). Patterns of attentional deficits and emotional bias in bipolar and major depressive disorder. The British Journal of Clinical Psychology, 44(Pt 3), 343–356. doi:10.1348/014466505X57755.CrossRefPubMed

Kessler, R. C., Walters, E. E., & Wittchen, H. U. (2004). Epidemiology. In R. G. Heimberg, C. L. Turk, & D. S. Mennin (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 29–50). New York: Guilford Press.

Kotov, R., Perlman, G., Gámez, W., & Watson, D. (2015). The structure and short-term stability of the emotional disorders: A dimensional approach. Psychological Medicine, 8, 1687–1698.CrossRef

Krueger, R. F., & Markon, K. E. (2006). Reinterpreting comorbidity: A model-based approach to understanding and classifying psychopathology. Annual Review of Clinical Psychology, 2, 111–133. doi:10.1146/annurev.clinpsy.2.022305.095213.CrossRefPubMedPubMedCentral

Kujawa, A., Hajcak, G., Torpey, D., Kim, J., & Klein, D. N. (2012). Electrocortical reactivity to emotional faces in young children and associations with maternal and paternal depression. Journal of Child Psychology and Psychiatry, 53, 207–215.CrossRefPubMedPubMedCentral

Lawrence, A. E., Liverant, G. I., Rosellini, A. J., & Brown, T. A. (2009). Generalized anxiety disorder within the course of major depressive disorder: Examining the utility of the DSM-IV hierarchy rule. Depression and Anxiety, 26(10), 909–916. doi:10.1002/da.20607.CrossRefPubMed

Lydiard, R. B., & Monnier, J. (2004). Pharmacological treatment. In R. G. Heimberg, C. L. Turk, & D. S. Mennin (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 351–382). New York: Guilford Press.

MacNamara, A., & Hajcak, G. (2009). Anxiety and spatial attention moderate the electrocortical response to aversive pictures. Neuropsychologia, 47, 2975–2980. doi:10.1016/j.neuropsychologia.2009.06.026.CrossRefPubMed

MacNamara, A., & Hajcak, G. (2010). Distinct electrocortical and behavioral evidence for increased attention to threat in generalized anxiety disorder. Depression and Anxiety, 27, 234–243. doi:10.1002/da.20679.CrossRefPubMed

MacNamara, A., & Proudfit, G. H. (2014). Cognitive load and emotional processing in generalized anxiety disorder: Electrocortical evidence for increased distractibility. Journal of Abnormal Psychology, 123(3), 557–565. doi:10.1037/a0036997.CrossRefPubMedPubMedCentral

Mathews, A., & MacLeod, C. (2005). Cognitive vulnerability to emotional disorders. Annual Review of Clinical Psychology, 1, 167–195.CrossRefPubMed

Mathews, A., Ridgeway, V., & Williamson, D. A. (1996). Evidence for attention to threatening stimuli in depression. Behaviour Research and Therapy, 34, 695–705.CrossRefPubMed

Mennin, D. S., Heimberg, R. G., Fresco, D. M., & Ritter, M. R. (2008). Is generalized anxiety disorder an anxiety or mood disorder? Considering multiple factors as we ponder the fate of GAD. Depression and Anxiety, 25, 289–299.CrossRefPubMed

Mennin, D. S., McLaughlin, K. A., & Flanagan, T. J. (2009). Emotion regulation deficits in generalized anxiety disorder, social anxiety disorder, and their co-occurrence. Journal of Anxiety Disorders, 23(7), 866–871. doi:10.1016/j.janxdis.2009.04.006.CrossRefPubMedPubMedCentral

Miller, G. A., Gratton, G., & Yee, C. M. (1988). Generalized implementation of an eye movement correction procedure. Psychophysiology, 25, 241–243. doi:10.1111/j.1469-8986.1988.tb00999.x.CrossRef

Mochcovitch, M. D., da Rocha Freire, R. C., Garcia, R. F., & Nardi, A. E. (2014). A systematic review of fMRI studies in generalized anxiety disorder: Evaluating its neural and cognitive basis. Journal of Affective Disorders, 167, 336–342. doi:10.1016/j.jad.2014.06.041.CrossRefPubMed

Moffitt, T. E., Harrington, H. L., Caspi, A., Kim-Cohen, J., Goldberg, D., Gregory, A. M., & Poulton, R. (2007). Depression and generalized anxiety disorder: Cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. Archives of General Psychiatry, 64, 651–660.CrossRefPubMed

Mogg, K., Bradley, B. P., & Williams, R. (1995). Attentional bias in anxiety and depression: The role of awareness. British Journal of Clinical Psychology, 34, 17–36.CrossRefPubMed

Mogg, K., Bradley, B. P., Williams, R., & Mathews, A. (1993). Subliminal processing of emotional information in anxiety and depression. Journal of Abnormal Psychology, 102, 304–311.CrossRefPubMed

Mogg, K., Holmes, A., Garner, M., & Bradley, B. P. (2008). Effects of threat cues on attentional shifting, disengagement and response slowing in anxious individuals. Behaviour Research and Therapy, 46, 656–667.CrossRefPubMedPubMedCentral

Morris, S. E., & Cuthbert, B. N. (2012). Research Domain Criteria: Cognitive systems, neural circuits, and dimensions of behavior. Dialogues in Clinical Neurosciences, 14(1), 29–37.

Nelson, B. D., Perlman, G., Hajcak, G., Klein, D. N., & Kotov, R. (2015). Familial risk for distress and fear disorders and emotional reactivity in adolescence: An event-related potential investigation. Psychological Medicine, 45(12), 2545–2556. doi:10.1017/S0033291715000471.CrossRefPubMedPubMedCentral

Nesse, R. M. (2000). Is depression an adaptation? Archives of General Psychiatry, 57, 14–20.CrossRefPubMed

Proudfit, G. H., Bress, J. N., Foti, D., Kujawa, A., & Klein, D. N. (2015). Depression and event-related potentials: Emotional disengagement and reward insensitivity. Current Opinion in Psychology, 4, 110–113. doi:10.1016/j.copsyc.2014.12.018.CrossRefPubMed

Rinck, M., Becker, E. S., Kellermann, J., & Roth, W. T. (2003). Selective attention in anxiety: Distraction and enhancement in visual search. Depression and Anxiety, 18, 18–28.CrossRefPubMed

Rivas-Vazquez, R. A. (2001). Antidepressants as first-line agents in the current pharmacotherapy of anxiety disorders. Professional Psychology: Research and Practice, 32, 101–104.CrossRef

Rottenberg, J., & Gross, J. J. (2006). When emotion goes wrong: Realizing the promise of affective science. Clinical Psychology: Science and Practice, 10(2), 227–232. doi:10.1093/clipsy.bpg012.

Rottenberg, J., Gross, J. J., & Gotlib, I. H. (2005). Emotion context insensitivity in major depressive disorder. Journal of Abnormal Psychology, 114, 627–639.CrossRefPubMed

Rottenberg, J., Kasch, K. L., Gross, J. J., & Gotlib, I. H. (2002). Sadness and amusement reactivity differentially predict concurrent and prospective functioning in major depressive disorder. Emotion, 2(2), 135–146. doi:10.1037/1528-3542.2.2.135.CrossRefPubMed

Roy, M. A., Neale, M. C., Pedersen, N. L., Mathe, A. A., & Kendler, K. S. (1995). A twin study of generalized anxiety disorder and major depression. Psychological Medicine, 25, 1037–1050.CrossRefPubMed

Ruggero, C. J., Kotov, R., Watson, D., Kilmer, J. N., Perlman, G., & Liu, K. (2014). Beyond a single index of mania symptoms: Structure and validity of subdimensions. Journal of Affective Disorders, 161, 8–15. doi:10.1016/j.jad.2014.02.044.CrossRefPubMed

Sass, S. M., Heller, W., Stewart, J. L., Silton, R. L., Edgar, J. C., Fisher, J. E., & Miller, G. A. (2009). Time course of attentional bias in anxiety: Emotion and gender specificity. Psychophysiology, 47, 247–259.CrossRefPubMedPubMedCentral

Schmukle, S. C. (2005). Unreliability of the dot probe task. European Journal of Personality, 19, 595–605.CrossRef

Schupp, H. T., Cuthbert, B. N., Bradley, M. M., Cacioppo, J. T., Ito, T., & Lang, P. J. (2000). Affective picture processing: The late positive potential is modulated by motivational relevance. Psychophysiology, 37, 257–261. doi:10.1111/1469-8986.3720257.CrossRefPubMed

Staugaard, S. R. (2009). Reliability of two versions of the dot-probe task using photographic faces. Psychology Science Quarterly, 51, 339–350.

Stockburger, J., Schmälzle, R., Flaisch, T., Bublatzky, F., & Schupp, H. T. (2009). The impact of hunger on food cue processing: An event-related brain potential study. Neuroimage, 47, 1819–1829.CrossRefPubMed

Taylor-Clift, A., Morris, B. H., Rottenberg, J., & Kovacs, M. (2011). Emotion-modulated startle in anxiety disorders is blunted by co-morbid depressive episodes. Psychological Medicine, 41(01), 129–139. doi:10.1017/S003329171000036X.CrossRefPubMed

Teachman, B. A., Joormann, J., Steinman, S. A., & Gotlib, I. H. (2012). Automaticity in anxiety disorders and major depressive disorder. Clinical Psychology Review, 32(6), 575–603. doi:10.1016/j.cpr.2012.06.004.CrossRefPubMedPubMedCentral

Vaidyanathan, U., Patrick, C. J., & Cuthbert, B. N. (2009). Linking dimensional models of internalizing psychopathology to neurobiological systems: Affect-modulated startle as an indicator of fear and distress disorders and affiliated traits. Psychological Bulletin, 135, 909–942.CrossRefPubMedPubMedCentral

Vico, C., Guerra, P., Robles, H., Vila, J., & Anllo-Vento, L. (2010). Affective processing of loved faces: Contributions from peripheral and central electrophysiology. Neuropsychologia, 48, 2894–2902. doi:10.1016/j.neuropsychologia.2010.05.031.CrossRefPubMed

Waechter, S., Nelson, A. L., Wright, C., Hyatt, A., & Oakman, J. (2013). Measuring attentional bias to threat: Reliability of dot probe and eye movement indices. Cognitive Therapy and Research, 38(3), 313–333. doi:10.1007/s10608-013-9588-2.CrossRef

Wang, L., LaBar, K. S., Smoski, M., Rosenthal, M. Z., Dolcos, F., Lynch, T. R., et al. (2008). Prefrontal mechanisms for executive control over emotional distraction are altered in major depression. Psychiatry Research, 163(2), 143–155. doi:10.1016/j.pscychresns.2007.10.004.CrossRefPubMedPubMedCentral

Watson, D. (2005). Rethinking the mood and anxiety disorders: A quantitative hierarchical model for DSM-V. Journal of Abnormal Psychology, 114, 522–536.CrossRefPubMed

Watson, D. (2009). Differentiating the mood and anxiety disorders: a quadripartite model. Annual Review of Clinical Psychology, 5, 221–247. doi:10.1146/annurev.clinpsy.032408.153510.CrossRefPubMed

Watson, D., Clark, L. A., Chmielewski, M., & Kotov, R. (2013). The value of suppressor effects in explicating the construct validity of symptom measures. Psychological Assessment, 25(3), 929–941. doi:10.1037/a0032781.CrossRefPubMedPubMedCentral

Watson, D., O’Hara, M. W., Naragon-Gainey, K., Koffel, E., Chmielewski, M., Kotov, R., et al. (2012). Development and validation of new anxiety and bipolar symptom scales for an expanded version of the IDAS (the IDAS-II). Assessment, 19(4), 399–420. doi:10.1177/1073191112449857.CrossRefPubMed

Weinberg, A., & Hajcak, G. (2011). Electrocortical evidence for vigilance–avoidance in generalized anxiety disorder. Psychophysiology, 48, 842–851.CrossRefPubMed

Weinberg, A., Klein, D. N., & Hajcak, G. (2012). Increased error-related brain activity distinguishes generalized anxiety disorder With and without comorbid major depressive disorder. Journal of Abnormal Psychology, 121, 885–896. doi:10.1037/a0028270.CrossRefPubMedPubMedCentral

Weinberg, A., Venables, N. C., Proudfit, G. H., & Patrick, C. J. (2015). Heritability of the neural response to emotional pictures: evidence from ERPs in an adult twin sample. Social Cognitive and Affective Neuroscience, 10(3), 424–434. doi:10.1093/scan/nsu059.CrossRefPubMedPubMedCentral

Wexler, B. E., Levenson, L., Warrenburg, S., & Price, L. H. (1994). Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research, 51(2), 127–138.CrossRefPubMed

Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1988). Cognitive psychology and emotional disorders. New York: Wiley.

Wright, C. I., Fischer, H., Whalen, P. J., McInerney, S. C., Shin, L. M., & Rauch, S. L. (2001). Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli. NeuroReport, 12, 379–383.CrossRefPubMed

Zimmerman, M., & Chelminski, I. (2003). Generalized anxiety disorder in patients with major depression: is DSM-IV’s hierarchy correct? The American Journal of Psychiatry, 160(3), 504–512.CrossRefPubMed

Titel: Diagnostic and Symptom-Based Predictors of Emotional Processing in Generalized Anxiety Disorder and Major Depressive Disorder: An Event-Related Potential Study
Auteurs: Annmarie MacNamara
Roman Kotov
Greg Hajcak
Publicatiedatum: 30-08-2015
Uitgeverij: Springer US
Gepubliceerd in: Cognitive Therapy and Research / Uitgave 3/2016
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI: https://doi.org/10.1007/s10608-015-9717-1

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