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Gepubliceerd in: Journal of Youth and Adolescence 1/2019

22-09-2018 | Empirical Research

Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use

Auteurs: Gabriel L. Schlomer, H. Harrington Cleveland, Arielle R. Deutsch, David J. Vandenbergh, Mark E. Feinberg, Mark T. Greenberg, Richard L. Spoth, Cleve Redmond

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 1/2019

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Abstract

Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.

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Literatuur
go back to reference Albert, D., Belsky, D., Crowley, D. M., Latendresse, S. J., Aliev, F., Riley, B., Dick, D. M., & Dodge, K. (2015). Can genetics predict response to complex behavioral interventions? Evidence from a genetic analysis of the Fast Track randomized control trial. Journal of Policy Analysis and Management, 34, 497–518. CrossRefPubMedPubMedCentral Albert, D., Belsky, D., Crowley, D. M., Latendresse, S. J., Aliev, F., Riley, B., Dick, D. M., & Dodge, K. (2015). Can genetics predict response to complex behavioral interventions? Evidence from a genetic analysis of the Fast Track randomized control trial. Journal of Policy Analysis and Management, 34, 497–518. CrossRefPubMedPubMedCentral
go back to reference Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse. Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300–304. CrossRef Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse. Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300–304. CrossRef
go back to reference Bjorklund, D. F., Ellis, B. J., & Rosenberg, J. S. (2007). Evolved probabilistic cognitive mechanisms: An evolutionary approach to gene × environment × development interactions. In R. V. Kail (Ed.), Advances in child development and behavior: Vol. 35. Advances in child development and behavior (pp. 1-36). San Diego, CA, US: Elsevier Academic Press. Bjorklund, D. F., Ellis, B. J., & Rosenberg, J. S. (2007). Evolved probabilistic cognitive mechanisms: An evolutionary approach to gene × environment × development interactions. In R. V. Kail (Ed.), Advances in child development and behavior: Vol. 35. Advances in child development and behavior (pp. 1-36). San Diego, CA, US: Elsevier Academic Press.
go back to reference Bongers, I. L., Koot, H. M., van der Ende, J., & Verhulst, F. C. (2004). Developmental trajectories of externalizing behaviors in childhood and adolescence. Child Development, 75, 1523–1537. CrossRefPubMed Bongers, I. L., Koot, H. M., van der Ende, J., & Verhulst, F. C. (2004). Developmental trajectories of externalizing behaviors in childhood and adolescence. Child Development, 75, 1523–1537. CrossRefPubMed
go back to reference Botvin, G. J., & Kantor, L. W. (2000). Preventing alcohol and tobacco use through life skills training: theory, methods, and emperical findings. Alcohol Research & Health, 24, 250–257. Botvin, G. J., & Kantor, L. W. (2000). Preventing alcohol and tobacco use through life skills training: theory, methods, and emperical findings. Alcohol Research & Health, 24, 250–257.
go back to reference Cleveland, H. H., Schlomer, G. L., Vandenbergh, D. J., & Wiebe, R. P. (2016). Gene x intervention designs: a promising step toward understanding etiology and building better preventative interventions. Journal of Criminology and Public Policy, 15, 711–720. CrossRef Cleveland, H. H., Schlomer, G. L., Vandenbergh, D. J., & Wiebe, R. P. (2016). Gene x intervention designs: a promising step toward understanding etiology and building better preventative interventions. Journal of Criminology and Public Policy, 15, 711–720. CrossRef
go back to reference Dahl, R. E., & Conway, A. M. (2009). Self-regulation and the developoment of behavioral and emotional problems: toward an integrative conceptual and translational research agenda. In S. L. Olsen & A. J. Sameroff (Eds.), Biopsychosocial regulatory processes in the development of childhood behavior problems. New York, NY: Cambridge University Press. Dahl, R. E., & Conway, A. M. (2009). Self-regulation and the developoment of behavioral and emotional problems: toward an integrative conceptual and translational research agenda. In S. L. Olsen & A. J. Sameroff (Eds.), Biopsychosocial regulatory processes in the development of childhood behavior problems. New York, NY: Cambridge University Press.
go back to reference Dick, D. M. (2013). Developmental considerations in gene identificiation efforts. In J. MacKillop & M. R. Munafò (Eds.), Genetic influences on addiction: an intermediate phenotype approach. Cambridge: The MIT Press. Dick, D. M. (2013). Developmental considerations in gene identificiation efforts. In J. MacKillop & M. R. Munafò (Eds.), Genetic influences on addiction: an intermediate phenotype approach. Cambridge: The MIT Press.
go back to reference Dick, D. M., Bierut, L., Hinrichs, A., Fox, L., Bucholz, K. K., Kramer, J., & Foroud, T. (2006). The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behavior Genetics, 36, 577–590. CrossRefPubMed Dick, D. M., Bierut, L., Hinrichs, A., Fox, L., Bucholz, K. K., Kramer, J., & Foroud, T. (2006). The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behavior Genetics, 36, 577–590. CrossRefPubMed
go back to reference Dick, D. M., Latendresse, S. J., Lansford, J. E., Budde, J. P., Goate, A., Dodge, K. A., & Bates, J. E. (2009). Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Archives of General Psychiatry, 66, 649–658. CrossRefPubMedPubMedCentral Dick, D. M., Latendresse, S. J., Lansford, J. E., Budde, J. P., Goate, A., Dodge, K. A., & Bates, J. E. (2009). Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Archives of General Psychiatry, 66, 649–658. CrossRefPubMedPubMedCentral
go back to reference Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., & Kwon, J. (2004). Variations in GABRA2, encoding the α2 subunit of the GABA A receptor, are associated with alcohol dependence and with brain oscillations. The American Journal of Human Genetics, 74, 705–714. CrossRefPubMed Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., & Kwon, J. (2004). Variations in GABRA2, encoding the α2 subunit of the GABA A receptor, are associated with alcohol dependence and with brain oscillations. The American Journal of Human Genetics, 74, 705–714. CrossRefPubMed
go back to reference Ellickson, P. L., McCaffrey, D. F., Ghosh-Dastidar, B., & Longshore, D. L. (2003). New inroads in preventing adolescent drug use: results from a large-scale trial of project ALERT in middle schools. American Journal of Public Health, 93(11), 1830–1836. CrossRefPubMedPubMedCentral Ellickson, P. L., McCaffrey, D. F., Ghosh-Dastidar, B., & Longshore, D. L. (2003). New inroads in preventing adolescent drug use: results from a large-scale trial of project ALERT in middle schools. American Journal of Public Health, 93(11), 1830–1836. CrossRefPubMedPubMedCentral
go back to reference Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: an evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7–28. https://​doi.​org/​10.​107/​s095457941000006​11.​ CrossRefPubMed Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: an evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7–28. https://​doi.​org/​10.​107/​s095457941000006​11.​ CrossRefPubMed
go back to reference Glenn, A. L., Lochman, J. E., Dishion, T., Powell, N. P., Boxmeyer, C., & Qu, L. (2018). Oxytocin receptor gene variant interacts with intervention delivery format in predicting intervention outcomes for youth with conduct problems. Prevention Science, 19, 38–48. https://​doi.​org/​10.​1007/​s11121-017-0777-1. Glenn, A. L., Lochman, J. E., Dishion, T., Powell, N. P., Boxmeyer, C., & Qu, L. (2018). Oxytocin receptor gene variant interacts with intervention delivery format in predicting intervention outcomes for youth with conduct problems. Prevention Science, 19, 38–48. https://​doi.​org/​10.​1007/​s11121-017-0777-1.
go back to reference Halder, I., Shriver, M., Thomas, M., Fernandez, J. R., & Frudakis, T. (2008). A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four contents: utility and applications. Human Mutation, 29, 648–658. CrossRefPubMed Halder, I., Shriver, M., Thomas, M., Fernandez, J. R., & Frudakis, T. (2008). A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four contents: utility and applications. Human Mutation, 29, 648–658. CrossRefPubMed
go back to reference Lind, P. A., MacGregor, S., Agrawal, A., Montgomery, G. W., Heath, A. C., Martin, N. G., & Whitfield, J. B. (2008). The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. Alcoholism: Clinical and Experimental Research, 32, 1721–1731. CrossRef Lind, P. A., MacGregor, S., Agrawal, A., Montgomery, G. W., Heath, A. C., Martin, N. G., & Whitfield, J. B. (2008). The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. Alcoholism: Clinical and Experimental Research, 32, 1721–1731. CrossRef
go back to reference Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychological Review, 100, 674–701. CrossRefPubMed Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychological Review, 100, 674–701. CrossRefPubMed
go back to reference Moffitt, T. E., Caspi, A., Harrington, H., & Milne, B. J. (2002). Males on the life-course-persistent and adolescence-limited antisocial pathways: follow-up at age 26 years. Development and Psychopathology, 14, 179–207. CrossRefPubMed Moffitt, T. E., Caspi, A., Harrington, H., & Milne, B. J. (2002). Males on the life-course-persistent and adolescence-limited antisocial pathways: follow-up at age 26 years. Development and Psychopathology, 14, 179–207. CrossRefPubMed
go back to reference Rose, R. J., & Dick, D. M. (2010). Commentary on Agrawal et al. (2010): social environments modulate alcohol use. Addiction, 105, 1854–1855. CrossRefPubMed Rose, R. J., & Dick, D. M. (2010). Commentary on Agrawal et al. (2010): social environments modulate alcohol use. Addiction, 105, 1854–1855. CrossRefPubMed
go back to reference Russell, M. A., Schlomer, G. L., Cleveland, H. H., Feinberg, M., Greenberg, M., Spoth, R., & Vandenbergh, D. J. (2018). PROSPER intervention effects on adolescents’ alcohol misuse vary by GABRA2 genotype and age. Prevention Science, 19, 27–37. CrossRefPubMedPubMedCentral Russell, M. A., Schlomer, G. L., Cleveland, H. H., Feinberg, M., Greenberg, M., Spoth, R., & Vandenbergh, D. J. (2018). PROSPER intervention effects on adolescents’ alcohol misuse vary by GABRA2 genotype and age. Prevention Science, 19, 27–37. CrossRefPubMedPubMedCentral
go back to reference SAS Institute Inc. 2011. SAS® 9.3 Statements: Reference. Cary, NC: SAS Institute Inc. SAS Institute Inc. 2011. SAS® 9.3 Statements: Reference. Cary, NC: SAS Institute Inc.
go back to reference Schlomer, G. L., Cleveland, H. H., Feinberg, M. E., Wolf, P. S. A., Greenberg, M. T., Spoth, R. L., Redmond, C., Tricou, E. P., & Vandenbergh, D. J. (2017). Extending previous cGxI findings on 5-HTTLPR’s moderation of intervention effects on adolescent substance misuse initiation. Child Development, 88, 2001–2012. https://​doi.​org/​10.​1111/​cdev.​12666. CrossRefPubMed Schlomer, G. L., Cleveland, H. H., Feinberg, M. E., Wolf, P. S. A., Greenberg, M. T., Spoth, R. L., Redmond, C., Tricou, E. P., & Vandenbergh, D. J. (2017). Extending previous cGxI findings on 5-HTTLPR’s moderation of intervention effects on adolescent substance misuse initiation. Child Development, 88, 2001–2012. https://​doi.​org/​10.​1111/​cdev.​12666. CrossRefPubMed
go back to reference Sieghart, W. (2006). Structure, pharmacology, and function of GABA A receptor subtypes. Advances in Pharmacology, 54, 251–263. Sieghart, W. (2006). Structure, pharmacology, and function of GABA A receptor subtypes. Advances in Pharmacology, 54, 251–263.
go back to reference Simons, R. L., Chao, W., Conger, R. D., & Elder, G. H. (2001). Quality of parenting as mediator of the effect of childhood defiance on adolescent friendship choices and delinquency. A growth curve analysis. Journal of Marriage and Family, 63, 63–79. CrossRef Simons, R. L., Chao, W., Conger, R. D., & Elder, G. H. (2001). Quality of parenting as mediator of the effect of childhood defiance on adolescent friendship choices and delinquency. A growth curve analysis. Journal of Marriage and Family, 63, 63–79. CrossRef
go back to reference Spoth, R., Greenberg, M., Bierman, K., & Redmond, C. (2004). PROSPER community-university partnership model for public education systems: capacity-building for evidence-based, competence-building prevention. Prevention Science, 5, 31–39. CrossRefPubMed Spoth, R., Greenberg, M., Bierman, K., & Redmond, C. (2004). PROSPER community-university partnership model for public education systems: capacity-building for evidence-based, competence-building prevention. Prevention Science, 5, 31–39. CrossRefPubMed
go back to reference Spoth, R., Redmond, C., Clair, S., Shin, C., Greenberg, M., & Feinberg, M. (2011). Preventing substance misuse through community–university partnerships: randomized controlled trial outcomes 4½ years past baseline. American Journal of Preventive Medicine, 40, 440–447. CrossRefPubMedPubMedCentral Spoth, R., Redmond, C., Clair, S., Shin, C., Greenberg, M., & Feinberg, M. (2011). Preventing substance misuse through community–university partnerships: randomized controlled trial outcomes 4½ years past baseline. American Journal of Preventive Medicine, 40, 440–447. CrossRefPubMedPubMedCentral
go back to reference Spoth, R. L., Trudeau, L. S., Redmond, C., Shin, C., Greenberg, M. T., Feinberg, M. E., & Hyun, G. (2015). PROSPER partnership delivery system: effects on adolescent conduct problem behavior outcomes through 6.5 years past baseline. Journal of Adolescence, 45, 44–55. CrossRefPubMedPubMedCentral Spoth, R. L., Trudeau, L. S., Redmond, C., Shin, C., Greenberg, M. T., Feinberg, M. E., & Hyun, G. (2015). PROSPER partnership delivery system: effects on adolescent conduct problem behavior outcomes through 6.5 years past baseline. Journal of Adolescence, 45, 44–55. CrossRefPubMedPubMedCentral
go back to reference Tan, X., Shiyko, M. P., Li, R., Li, Y., & Dierker, L. (2012). A time-varying effect model for intensive longitudinal data. Psychological Methods, 17, 61–77. CrossRefPubMed Tan, X., Shiyko, M. P., Li, R., Li, Y., & Dierker, L. (2012). A time-varying effect model for intensive longitudinal data. Psychological Methods, 17, 61–77. CrossRefPubMed
go back to reference Trucco, E. M., Schlomer, G. L., & Hicks, B. M. (2018). A developmental perspective on the genetic basis of alcohol use disorder. In H. E. Fitzgerald & L. I. Puttler (Eds.), Alcohol Use Disorders: A Developmental Science Approach to Etiology. New York, NY: Oxford University Press. Trucco, E. M., Schlomer, G. L., & Hicks, B. M. (2018). A developmental perspective on the genetic basis of alcohol use disorder. In H. E. Fitzgerald & L. I. Puttler (Eds.), Alcohol Use Disorders: A Developmental Science Approach to Etiology. New York, NY: Oxford University Press.
go back to reference Trucco, E. M., Villafuerete, S., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2017). Beyond risk: prospective effects of GABA receptor subunit alpha-2 (GABRA2) x positive peer involvement on adolescent behavior. Development and Psychopathology, 29, 711–724. CrossRefPubMed Trucco, E. M., Villafuerete, S., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2017). Beyond risk: prospective effects of GABA receptor subunit alpha-2 (GABRA2) x positive peer involvement on adolescent behavior. Development and Psychopathology, 29, 711–724. CrossRefPubMed
go back to reference Trucco, E. M., Villafuerete, S., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2014). Rule breaking mediates the developmental association between GABRA2 and adolescent substance use. Journal of Child Psychology and Psychiatry, 55, 1372–1379. CrossRefPubMed Trucco, E. M., Villafuerete, S., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2014). Rule breaking mediates the developmental association between GABRA2 and adolescent substance use. Journal of Child Psychology and Psychiatry, 55, 1372–1379. CrossRefPubMed
Metagegevens
Titel
Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use
Auteurs
Gabriel L. Schlomer
H. Harrington Cleveland
Arielle R. Deutsch
David J. Vandenbergh
Mark E. Feinberg
Mark T. Greenberg
Richard L. Spoth
Cleve Redmond
Publicatiedatum
22-09-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Youth and Adolescence / Uitgave 1/2019
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI
https://doi.org/10.1007/s10964-018-0929-z