Skip to main content
Top
Gepubliceerd in:

10-07-2017 | Letter to the Editor

Developing Clinically Practicable Biomarkers for Autism Spectrum Disorder

Auteur: James C. McPartland

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Despite significant advances in understanding the biological bases of autism spectrum disorder (ASD), the field remains primarily reliant on observational and parent report measures of behavior to guide clinical practice, conduct research, and evaluate intervention outcomes. There is a critical need for objective measures to more sensitively and validly quantify risk for ASD, ASD symptomatology, and its change in clinical trials. To maximize public health impact, such biomarkers must be cost effective and utilize accessible and scalable technologies. This letter describes concerns specific to the development of clinically practicable biomarkers for ASD and approaches to optimize understanding of these biomarkers through development of large-scale consortia and clinical networks.
Literatuur
go back to reference Dawson, G., Sun, J. M., Davlantis, K. S., Murias, M., Franz, L., Troy, J., et al. (2017). Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: results of a single-center phase I open-label trial. Stem Cells Translational Medicine, 6(5), 1332–1339. doi:10.1002/sctm.16-0474.CrossRefPubMedPubMedCentral Dawson, G., Sun, J. M., Davlantis, K. S., Murias, M., Franz, L., Troy, J., et al. (2017). Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: results of a single-center phase I open-label trial. Stem Cells Translational Medicine, 6(5), 1332–1339. doi:10.​1002/​sctm.​16-0474.CrossRefPubMedPubMedCentral
go back to reference Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., et al. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167(7), 748–751. doi:10.1176/appi.ajp.2010.09091379.CrossRefPubMed Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., et al. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167(7), 748–751. doi:10.​1176/​appi.​ajp.​2010.​09091379.CrossRefPubMed
go back to reference Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250. Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.
go back to reference Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule, (2nd ed.). Torrance, CA: Western Psychological Services. Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule, (2nd ed.). Torrance, CA: Western Psychological Services.
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMed Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMed
go back to reference Morton, J., & Johnson, M. H. (1991). CONSPEC and CONLERN: A two-process theory of infant face recognition. Psychological Review, 98(2), 164–181.CrossRefPubMed Morton, J., & Johnson, M. H. (1991). CONSPEC and CONLERN: A two-process theory of infant face recognition. Psychological Review, 98(2), 164–181.CrossRefPubMed
Metagegevens
Titel
Developing Clinically Practicable Biomarkers for Autism Spectrum Disorder
Auteur
James C. McPartland
Publicatiedatum
10-07-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3237-7