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Gepubliceerd in: Quality of Life Research 2/2018

13-10-2017

Developing a patient-reported outcome measure for HIV care on perceived barriers to antiretroviral adherence: assessing the needs of HIV clinicians through qualitative analysis

Auteurs: Isabelle Toupin, Kim Engler, David Lessard, Leo Wong, Andràs Lènàrt, Bruno Spire, François Raffi, Bertrand Lebouché

Gepubliceerd in: Quality of Life Research | Uitgave 2/2018

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Abstract

Purpose

To identify HIV clinicians’ needs for the clinical use of a new patient-reported outcome measure (PRO) on barriers to antiretroviral therapy (ART) adherence.

Methods

In 2015, five focus groups with 31 clinicians from France were transcribed, coded with Atlas.ti, and submitted to a typological analysis.

Results

The analysis identified seven patient profiles, each tied to distinct barriers to adherence and to specific needs for the PRO’s content, data collection and transmission. Clinicians preferred, for the patient who is: (1) ‘passive,’ that the PRO collect information on ART knowledge, to ensure that the prescription’s instructions are being respected; (2) ‘misleading,’ that it be able to detect adherence to ART and socially desirable responses; (3) ‘stoic,’ that questions challenge the patient to recognize treatment-specific side effects; (4) ‘hedonistic,’ that the PRO contains content on lifestyle and risk-taking; (5) ‘obsessive,’ that the PRO captures quality of life and stressful life events; (6) ‘overburdened,’ that the PRO provides information on the person’s home environment, socioeconomic status and cultural constraints. For all or most patient profiles, the clinicians wished that the PRO be completed, minimally, prior to the medical consultation and to receive alerts, under varying conditions, when problematic scores were detected. Depending on the profile, there was preference for the inclusion of open-ended questions and transmission of cross-sectional, periodic or longitudinal PRO data.

Conclusion

Overall, this study’s findings suggest that to support the clinical management of ART adherence, our PRO must meet the needs of a wide variety of patients and must perform multiple functions.
Literatuur
1.
go back to reference Ammassari, A., Trotta, M. P., Shalev, N., Marconi, P., & Antinori, A. (2012). Beyond virological suppression: The role of adherence in the late HAART era. Antiviral Therapy, 17(5), 785–792. doi:10.3851/IMP2084.CrossRefPubMed Ammassari, A., Trotta, M. P., Shalev, N., Marconi, P., & Antinori, A. (2012). Beyond virological suppression: The role of adherence in the late HAART era. Antiviral Therapy, 17(5), 785–792. doi:10.​3851/​IMP2084.CrossRefPubMed
2.
3.
go back to reference Laws, M., Beach, M. C., & Lee, Y. (2012). Provider-patient adherence dialogue in HIV care: results of a multisite study. AIDS and Behavior, 17(1), 148–159.CrossRef Laws, M., Beach, M. C., & Lee, Y. (2012). Provider-patient adherence dialogue in HIV care: results of a multisite study. AIDS and Behavior, 17(1), 148–159.CrossRef
4.
go back to reference Robert, K. (2000). Physician beliefs about antiretroviral adherence communication. AIDS Patient Care and STDs, 14(9), 477–484.CrossRef Robert, K. (2000). Physician beliefs about antiretroviral adherence communication. AIDS Patient Care and STDs, 14(9), 477–484.CrossRef
5.
go back to reference Katz, I. T., Ryu, A. E., Onuegbu, A. G., Psaros, C., Weiser, S. D., Bangsberg, D. R., et al. (2013). Impact of HIV-related stigma on treatment adherence: Systematic review and meta-synthesis. Journal of the International AIDS Society, 16(3 Suppl 2), 18640. doi:10.7448/IAS.16.3.18640.PubMedPubMedCentral Katz, I. T., Ryu, A. E., Onuegbu, A. G., Psaros, C., Weiser, S. D., Bangsberg, D. R., et al. (2013). Impact of HIV-related stigma on treatment adherence: Systematic review and meta-synthesis. Journal of the International AIDS Society, 16(3 Suppl 2), 18640. doi:10.​7448/​IAS.​16.​3.​18640.PubMedPubMedCentral
6.
go back to reference Bolsewicz, K., Debattista, J., Vallely, A., Whittaker, A., & Fitzgerald, L. (2015). Factors associated with antiretroviral treatment uptake and adherence: a review. Perspectives from Australia, Canada, and the United Kingdom. AIDS Care, 27(12), 1429–1438. doi:10.1080/09540121.2015.1114992.CrossRefPubMed Bolsewicz, K., Debattista, J., Vallely, A., Whittaker, A., & Fitzgerald, L. (2015). Factors associated with antiretroviral treatment uptake and adherence: a review. Perspectives from Australia, Canada, and the United Kingdom. AIDS Care, 27(12), 1429–1438. doi:10.​1080/​09540121.​2015.​1114992.CrossRefPubMed
7.
go back to reference Kozak, M. S., Mugavero, M. J., Ye, J., Aban, I., Lawrence, S. T., Nevin, C. R., et al. (2012). Patient reported outcomes in routine care: advancing data capture for HIV cohort research. Clinical Infectious Diseases, 54(1), 141–147. doi:10.1093/cid/cir727.CrossRefPubMed Kozak, M. S., Mugavero, M. J., Ye, J., Aban, I., Lawrence, S. T., Nevin, C. R., et al. (2012). Patient reported outcomes in routine care: advancing data capture for HIV cohort research. Clinical Infectious Diseases, 54(1), 141–147. doi:10.​1093/​cid/​cir727.CrossRefPubMed
8.
go back to reference Simpson, K. N., Hanson, K. A., Harding, G., Haider, S., Tawadrous, M., Khachatryan, A., et al. (2013). Patient reported outcome instruments used in clinical trials of HIV-infected adults on NNRTI-based therapy: a 10-year review. Health and Quality of Life Outcomes, 11, 164. doi:10.1186/1477-7525-11-164.CrossRefPubMedPubMedCentral Simpson, K. N., Hanson, K. A., Harding, G., Haider, S., Tawadrous, M., Khachatryan, A., et al. (2013). Patient reported outcome instruments used in clinical trials of HIV-infected adults on NNRTI-based therapy: a 10-year review. Health and Quality of Life Outcomes, 11, 164. doi:10.​1186/​1477-7525-11-164.CrossRefPubMedPubMedCentral
12.
go back to reference Kwan, B. M., Sills, M. R., Graham, D., Hamer, M. K., Fairclough, D. L., Hammermeister, K. E., et al. (2016). Stakeholder engagement in a patient-reported outcomes (pro) measure implementation: A report from the SAFTINet practice-based research network (PBRN). Journal of The American Board of Family Medicine, 29(1), 102–115. doi:10.3122/jabfm.2016.01.150141.CrossRefPubMed Kwan, B. M., Sills, M. R., Graham, D., Hamer, M. K., Fairclough, D. L., Hammermeister, K. E., et al. (2016). Stakeholder engagement in a patient-reported outcomes (pro) measure implementation: A report from the SAFTINet practice-based research network (PBRN). Journal of The American Board of Family Medicine, 29(1), 102–115. doi:10.​3122/​jabfm.​2016.​01.​150141.CrossRefPubMed
13.
go back to reference Valderas, J. M., Kotzeva, A., Espallargues, M., Guyatt, G., Ferrans, C. E., Halyard, M. Y., et al. (2008). The impact of measuring patient-reported outcomes in clinical practice: a systematic review of the literature. Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care And Rehabilitation, 17(2), 179–193.CrossRef Valderas, J. M., Kotzeva, A., Espallargues, M., Guyatt, G., Ferrans, C. E., Halyard, M. Y., et al. (2008). The impact of measuring patient-reported outcomes in clinical practice: a systematic review of the literature. Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care And Rehabilitation, 17(2), 179–193.CrossRef
14.
go back to reference Batty, M. J., Moldavsky, M., Foroushani, P. S., Pass, S., Marriott, M., Sayal, K., et al. (2013). Implementing routine outcome measures in child and adolescent mental health services: from present to future practice. Child and Adolescent Mental Health, 18(2), 82–87.CrossRef Batty, M. J., Moldavsky, M., Foroushani, P. S., Pass, S., Marriott, M., Sayal, K., et al. (2013). Implementing routine outcome measures in child and adolescent mental health services: from present to future practice. Child and Adolescent Mental Health, 18(2), 82–87.CrossRef
16.
go back to reference Boyce, M. B., Browne, J. P., & Greenhalgh, J. (2014). The experiences of professionals with using information from patient-reported outcome measures to improve the quality of healthcare: a systematic review of qualitative research. BMJ Quality & Safety, 23, 508–518.CrossRef Boyce, M. B., Browne, J. P., & Greenhalgh, J. (2014). The experiences of professionals with using information from patient-reported outcome measures to improve the quality of healthcare: a systematic review of qualitative research. BMJ Quality & Safety, 23, 508–518.CrossRef
17.
go back to reference Engler, K., Lessard, D., Toupin, I., Lènàrt, A., & Lebouché, B. (2017). Engaging stakeholders into an electronic patient-reported outcome development study: on making an HIV-specific e-PRO patient-centered. Health Policy and Technology, 6(1), 59–66.CrossRef Engler, K., Lessard, D., Toupin, I., Lènàrt, A., & Lebouché, B. (2017). Engaging stakeholders into an electronic patient-reported outcome development study: on making an HIV-specific e-PRO patient-centered. Health Policy and Technology, 6(1), 59–66.CrossRef
18.
go back to reference Toupin, I., Engler, K., Lessard, D., Wong, L., Lènàrt, A., Raffi, F., et al. (2016). Developing a patient reported outcome measure (PRO) for HIV care on perceived barriers to antiretroviral adherence: Assessing the needs of HIV clinicians through typological analysis. Paper presented at the Poster presented at HIV Drug Therapy, Glasgow. Toupin, I., Engler, K., Lessard, D., Wong, L., Lènàrt, A., Raffi, F., et al. (2016). Developing a patient reported outcome measure (PRO) for HIV care on perceived barriers to antiretroviral adherence: Assessing the needs of HIV clinicians through typological analysis. Paper presented at the Poster presented at HIV Drug Therapy, Glasgow.
19.
20.
go back to reference Van der Maren, J. M. (2006). Méthodes de recherche pour l’éducation (2ed.). Montreal: Presses de l’Université de Montréal et de Boeck. Van der Maren, J. M. (2006). Méthodes de recherche pour l’éducation (2ed.). Montreal: Presses de l’Université de Montréal et de Boeck.
21.
go back to reference Marchand, J., & Giroux, C. (2010). L’utilisation des groupes de discussion en marketing commercial et social. Recheches Qualitatives, 29(1), 99–109. Marchand, J., & Giroux, C. (2010). L’utilisation des groupes de discussion en marketing commercial et social. Recheches Qualitatives, 29(1), 99–109.
22.
go back to reference Kitzinger, J. (1995). Qualitative research. Introducing focus groups. BMJ (Clinical Research ed.), 311(7000), 299–302.CrossRef Kitzinger, J. (1995). Qualitative research. Introducing focus groups. BMJ (Clinical Research ed.), 311(7000), 299–302.CrossRef
23.
go back to reference Engler, K., Lènàrt, A., Lessard, D., Toupin, I., & Lebouché, B. (2017). A synthesis of qualitative research with adults living with HIV on barriers to ART adherence (Abstract #118). Paper presented at the 12th International Conference on HIV Treatment and Prevention Adherence, Miami, USA, June 4–6. Engler, K., Lènàrt, A., Lessard, D., Toupin, I., & Lebouché, B. (2017). A synthesis of qualitative research with adults living with HIV on barriers to ART adherence (Abstract #118). Paper presented at the 12th International Conference on HIV Treatment and Prevention Adherence, Miami, USA, June 4–6.
24.
go back to reference Poupart, J. (1997). L’entretien de type qualitatif: considérations épistémologiques, théoriques et méthodologiques. In J. Poupart, L.-H. Deslauriers, J.-P. Groulx, A. Laperrière, R. Mayer & A. P. Pires (Eds.), La recherche qualitative. Enjeux épistémologiques et méthodologiques. Montréal: Gaëtan Morin. Poupart, J. (1997). L’entretien de type qualitatif: considérations épistémologiques, théoriques et méthodologiques. In J. Poupart, L.-H. Deslauriers, J.-P. Groulx, A. Laperrière, R. Mayer & A. P. Pires (Eds.), La recherche qualitative. Enjeux épistémologiques et méthodologiques. Montréal: Gaëtan Morin.
25.
go back to reference Baribeau, C. (2009). Analyse des données des entretiens de groupe. Recheches Qualitatives, 28(1), 133–148. Baribeau, C. (2009). Analyse des données des entretiens de groupe. Recheches Qualitatives, 28(1), 133–148.
26.
go back to reference Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77–101.CrossRef Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77–101.CrossRef
27.
go back to reference Charmaz, K. (2000). Grounded theory: Objectivist and constructivist methods. In N. K. Denzin & Y. S. Lincoln (Eds.), Handbook of qualitative research (2 ed., pp. 509–535). Californie: Sage Publications. Charmaz, K. (2000). Grounded theory: Objectivist and constructivist methods. In N. K. Denzin & Y. S. Lincoln (Eds.), Handbook of qualitative research (2 ed., pp. 509–535). Californie: Sage Publications.
28.
go back to reference Schnapper, D. (2005). La compréhension sociologique. Démarche de l’analyse typologique. Paris: Presses de l’Université de France. Schnapper, D. (2005). La compréhension sociologique. Démarche de l’analyse typologique. Paris: Presses de l’Université de France.
29.
go back to reference Harding, R., Liu, L., Catalan, J., & Sherr, L. (2011). What is the evidence for effectiveness of interventions to enhance coping among people living with HIV disease? A systematic review. Psychology Health and Medicine, 16(5), 564–587.CrossRef Harding, R., Liu, L., Catalan, J., & Sherr, L. (2011). What is the evidence for effectiveness of interventions to enhance coping among people living with HIV disease? A systematic review. Psychology Health and Medicine, 16(5), 564–587.CrossRef
30.
go back to reference Mulkins, A. L., Ibanez-Carrasco, F., Boyack, D., & Verhoef, M. J. (2014). The Living Well Lab: A community-based HIV/AIDS research initiative. Journal of Complementary and Integrative Medicine, 11(3), 213–222. doi:10.1515/jcim-2013-0057.CrossRefPubMed Mulkins, A. L., Ibanez-Carrasco, F., Boyack, D., & Verhoef, M. J. (2014). The Living Well Lab: A community-based HIV/AIDS research initiative. Journal of Complementary and Integrative Medicine, 11(3), 213–222. doi:10.​1515/​jcim-2013-0057.CrossRefPubMed
31.
go back to reference Panel on Antiretroviral Guidelines for Adults and Adolescents (2016). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In Health & Human Services (Eds.), (pp. 1–139). Panel on Antiretroviral Guidelines for Adults and Adolescents (2016). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. In Health & Human Services (Eds.), (pp. 1–139).
33.
go back to reference Orchard, T., Salters, K., Palmer, A., Michelow, W., Lepik, K. J., & Hogg, R. (2015). Vets, denialists and rememberers: Social typologies of patient adherence and non-adherence to HAART from the perspective of HIV care providers. AIDS Care, 27(6), 758–761. doi:10.1080/09540121.2015.1005003.CrossRefPubMed Orchard, T., Salters, K., Palmer, A., Michelow, W., Lepik, K. J., & Hogg, R. (2015). Vets, denialists and rememberers: Social typologies of patient adherence and non-adherence to HAART from the perspective of HIV care providers. AIDS Care, 27(6), 758–761. doi:10.​1080/​09540121.​2015.​1005003.CrossRefPubMed
34.
go back to reference Bogart, L. M., Catz, S. L., Kelly, J. A., & Benotsch, E. G. (2001). Factors influencing physicians’ judgments of adherence and treatment decisions for patients with HIV disease. Medical Decision Making: An International Journal of the Society for Medical Decision Making, 21(1), 28–36.CrossRef Bogart, L. M., Catz, S. L., Kelly, J. A., & Benotsch, E. G. (2001). Factors influencing physicians’ judgments of adherence and treatment decisions for patients with HIV disease. Medical Decision Making: An International Journal of the Society for Medical Decision Making, 21(1), 28–36.CrossRef
36.
38.
go back to reference O’Connor, J. L., Gardner, E. M., Mannheimer, S. B., Lifson, A. R., Esser, S., Telzak, E. E., et al. (2013). Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial. Journal of Infectious Diseases, 208(1), 40–49. doi:10.1093/infdis/jis731.CrossRefPubMed O’Connor, J. L., Gardner, E. M., Mannheimer, S. B., Lifson, A. R., Esser, S., Telzak, E. E., et al. (2013). Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial. Journal of Infectious Diseases, 208(1), 40–49. doi:10.​1093/​infdis/​jis731.CrossRefPubMed
39.
go back to reference Marewski, J. N., & Gigerenzer, G. (2012). Heuristic decision making in medicine. Dialogues in Clinical Neuroscience, 14(1), 77–89.PubMedPubMedCentral Marewski, J. N., & Gigerenzer, G. (2012). Heuristic decision making in medicine. Dialogues in Clinical Neuroscience, 14(1), 77–89.PubMedPubMedCentral
40.
go back to reference Blair, I. V., Steiner, J. F., & Havranek, E. P. (2011). Unconscious (implicit) bias and health disparities: Where do we go from here? The Permanente Journal, 15(2), 71–78.PubMedPubMedCentral Blair, I. V., Steiner, J. F., & Havranek, E. P. (2011). Unconscious (implicit) bias and health disparities: Where do we go from here? The Permanente Journal, 15(2), 71–78.PubMedPubMedCentral
41.
go back to reference Jacoby, A. (1994). Felt versus enacted stigma: a concept revisited. evidence from a study of people with epilepsy in remission. Social Science & Medicine, 38(2), 269–274.CrossRef Jacoby, A. (1994). Felt versus enacted stigma: a concept revisited. evidence from a study of people with epilepsy in remission. Social Science & Medicine, 38(2), 269–274.CrossRef
42.
go back to reference Phelan, S. M., Burgess, D. J., Yeazel, M. W., Hellerstedt, W. L., Griffin, J. M., & van Ryn, M. (2015). Impact of weight bias and stigma on quality of care and outcomes for patients with obesity. Obesity Reviews : An Official Journal of The International Association for the Study of Obesity International Association for the Study of Obesity, 16(4), 319–326. doi:10.1111/obr.12266.CrossRef Phelan, S. M., Burgess, D. J., Yeazel, M. W., Hellerstedt, W. L., Griffin, J. M., & van Ryn, M. (2015). Impact of weight bias and stigma on quality of care and outcomes for patients with obesity. Obesity Reviews : An Official Journal of The International Association for the Study of Obesity International Association for the Study of Obesity, 16(4), 319–326. doi:10.​1111/​obr.​12266.CrossRef
43.
go back to reference Barfod, T. S., Hecht, F. M., Rubow, C., & Gerstoft, J. (2006). Physicians communication with patients about adherence to HIV medication in San Francisco and Copenhagen: a qualitative study using Grounded Theory. BMC Health Services Research, 6, 154. doi:10.1186/1472-6963-6-154.CrossRefPubMedPubMedCentral Barfod, T. S., Hecht, F. M., Rubow, C., & Gerstoft, J. (2006). Physicians communication with patients about adherence to HIV medication in San Francisco and Copenhagen: a qualitative study using Grounded Theory. BMC Health Services Research, 6, 154. doi:10.​1186/​1472-6963-6-154.CrossRefPubMedPubMedCentral
44.
go back to reference Poppa, A., Davidson, O., Deutsch, J., Godfrey, D., Fisher, M., Head, S., et al. (2004). British HIV Association (BHIVA)/British Association for Sexual Health and HIV (BASHH) guidelines on provision of adherence support to individuals receiving antiretroviral therapy (2003). HIV Medicine, 5(Suppl 2), 46–60. doi:10.1111/j.1468-1293.2004.00215.x.CrossRefPubMed Poppa, A., Davidson, O., Deutsch, J., Godfrey, D., Fisher, M., Head, S., et al. (2004). British HIV Association (BHIVA)/British Association for Sexual Health and HIV (BASHH) guidelines on provision of adherence support to individuals receiving antiretroviral therapy (2003). HIV Medicine, 5(Suppl 2), 46–60. doi:10.​1111/​j.​1468-1293.​2004.​00215.​x.CrossRefPubMed
47.
go back to reference Lagu, T., Goff, S. L., Hannon, N. S., Shatz, A., & Lindenauer, P. K. (2013). A mixed-methods analysis of patient reviews of hospital care in England: implications for public reporting of health care quality data in the United States. The Joint Commission Journal on Quality and Patient Safety, 39(1), 7–15.CrossRefPubMed Lagu, T., Goff, S. L., Hannon, N. S., Shatz, A., & Lindenauer, P. K. (2013). A mixed-methods analysis of patient reviews of hospital care in England: implications for public reporting of health care quality data in the United States. The Joint Commission Journal on Quality and Patient Safety, 39(1), 7–15.CrossRefPubMed
49.
50.
go back to reference Fowler, F. J. (1996). Jr. Data collection methods. In B. Spilker (Ed.), Quality of Life and Pharmacoeconomics in Clinical Trials (2 ed.). Philadelphia: Lippincott-Raven. Fowler, F. J. (1996). Jr. Data collection methods. In B. Spilker (Ed.), Quality of Life and Pharmacoeconomics in Clinical Trials (2 ed.). Philadelphia: Lippincott-Raven.
51.
go back to reference Naughton, M. J., Shumaker, S. A., Anderson, R. T., & Czajkowski, S. M. (1996). Psychological aspects of health-related quality of life measurement: tests and scales. In B. Spilker (Ed.), Quality of life and pharmacoeconomics in clinical trials (2 ed.). Philadelphia: Lippincott-Raven. Naughton, M. J., Shumaker, S. A., Anderson, R. T., & Czajkowski, S. M. (1996). Psychological aspects of health-related quality of life measurement: tests and scales. In B. Spilker (Ed.), Quality of life and pharmacoeconomics in clinical trials (2 ed.). Philadelphia: Lippincott-Raven.
52.
go back to reference Van Vliet, L. M., Harding, R., Bausewein, C., Payne, S., Higginson, I. J., & EUROIMPACT (2015). How should we manage information needs, family anxiety, depression and breathlessness for those affected by advanced disease: development of a clinical decision support tool using a Delphi design. BMC Medicine, 13, 263. doi:10.1186/s12916-015-0449-6.CrossRefPubMedPubMedCentral Van Vliet, L. M., Harding, R., Bausewein, C., Payne, S., Higginson, I. J., & EUROIMPACT (2015). How should we manage information needs, family anxiety, depression and breathlessness for those affected by advanced disease: development of a clinical decision support tool using a Delphi design. BMC Medicine, 13, 263. doi:10.​1186/​s12916-015-0449-6.CrossRefPubMedPubMedCentral
54.
go back to reference Aaronson, N. K., Elliott, T. E., Greenhalgh, J., Halyard, M. Y., Hess, R., Miller, D. M., et al. (2015) User’s guide to implementing patient-reported outcomes assessment in clinical practice. International Society for Quality of Life Research, Version. Aaronson, N. K., Elliott, T. E., Greenhalgh, J., Halyard, M. Y., Hess, R., Miller, D. M., et al. (2015) User’s guide to implementing patient-reported outcomes assessment in clinical practice. International Society for Quality of Life Research, Version.
56.
go back to reference Segal, C., Holve, E., & Sabharwal, R. (2013). Collecting and using patient-reported outcomes (pro) for comparative effectiveness research (CER) and patient-centered outcomes research (pcor): Challenges and opportunities. Issue Briefs and Reports. Paper 10. Segal, C., Holve, E., & Sabharwal, R. (2013). Collecting and using patient-reported outcomes (pro) for comparative effectiveness research (CER) and patient-centered outcomes research (pcor): Challenges and opportunities. Issue Briefs and Reports. Paper 10.
57.
go back to reference Pourtois, J. & Desmet, H. (1997). Épistemologie et instumentation en sciences humaines (2nd ed.). Sprimont: Margada Editeur. Pourtois, J. & Desmet, H. (1997). Épistemologie et instumentation en sciences humaines (2nd ed.). Sprimont: Margada Editeur.
Metagegevens
Titel
Developing a patient-reported outcome measure for HIV care on perceived barriers to antiretroviral adherence: assessing the needs of HIV clinicians through qualitative analysis
Auteurs
Isabelle Toupin
Kim Engler
David Lessard
Leo Wong
Andràs Lènàrt
Bruno Spire
François Raffi
Bertrand Lebouché
Publicatiedatum
13-10-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1711-5

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