Skip to main content


Swipe om te navigeren naar een ander artikel

01-11-2013 | Uitgave 9/2013

Quality of Life Research 9/2013

Deriving clinically meaningful cut-scores for fatigue in a cohort of breast cancer survivors: a Health, Eating, Activity, and Lifestyle (HEAL) Study

Quality of Life Research > Uitgave 9/2013
Angela M. Stover, Bryce B. Reeve, Barbara F. Piper, Catherine M. Alfano, Ashley Wilder Smith, Sandra A. Mitchell, Leslie Bernstein, Kathy B. Baumgartner, Anne McTiernan, Rachel Ballard-Barbash
Belangrijke opmerkingen
Portions of this manuscript were presented at the 2012 annual meetings for the Society of Behavioral Medicine (SBM) and the International Society for Quality of Life Research (ISOQOL).



To empirically determine clinically meaningful cut-scores on the 0–10 response scale of the revised Piper Fatigue Scale (PFS-R) and its shorter version (PFS-12). Breast cancer survivors were classified (i.e., none, mild, moderate, or severe fatigue) based on the cut-scores, and relationships between these cut-scores and decrements in health-related quality of life (HRQOL) were examined.


A total of 857 breast cancer survivors, stages in situ-IIIa, from the Health, Eating, Activity, and Lifestyle (HEAL) Study were eligible. Survivors completed the PFS-R, SF-36, and a sexual health scale approximately 3 years after diagnosis. Multivariate analysis of covariance was used to examine five fatigue severity cut-score models, controlling for demographics, clinical characteristics, comorbidity, and antidepressant use. Multivariate regression was used to examine HRQOL decrements by cut-score category.


Analyses supported two similar fatigue severity cut-score models for the PFS-R and PFS-12: Model A.) none (0), mild (1–3), moderate (4–6), and severe (7–10); and Model D.) none (0), mild (1–2), moderate (3–5), and severe (6–10). For every threshold increase in fatigue severity, clinically meaningful decrements in physical, mental, and sexual health scores were observed, supporting construct validity of the fatigue cut-scores.


Standardized fatigue cut-scores may enhance interpretability and comparability across studies and populations and guide treating planning.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Over dit artikel

Andere artikelen Uitgave 9/2013

Quality of Life Research 9/2013 Naar de uitgave