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Gepubliceerd in:

21-06-2017

Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways

Auteurs: Diana A. Chirinos, Indira Gurubhagavatula, Preston Broderick, Julio A. Chirinos, Karen Teff, Thomas Wadden, Greg Maislin, Hassam Saif, Jesse Chittams, Caitlin Cassidy, Alexandra L. Hanlon, Allan I. Pack

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2017

Abstract

This study examined the association between depressive symptoms, as well as depressive symptom dimensions, and three candidate biological pathways linking them to Obstructive sleep apnea (OSA): (1) inflammation; (2) circulating leptin; and (3) intermittent hypoxemia. Participants included 181 obese adults with moderate-to-severe OSA enrolled in the Cardiovascular Consequences of Sleep Apnea (COSA) trial. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II). We assessed inflammation using C-reactive protein levels (CRP), circulating leptin by radioimmunoassay using a double antibody/PEG assay, and intermittent hypoxemia by the percentage of sleep time each patient had below 90% oxyhemoglobin saturation. We found no significant associations between BDI-II total or cognitive scores and CRP, leptin, or percentage of sleep time below 90% oxyhemoglobin saturation after controlling for relevant confounding factors. Somatic symptoms, however, were positively associated with percentage of sleep time below 90% saturation (β = 0.202, P = 0.032), but not with CRP or circulating leptin in adjusted models. Another significant predictor of depressive symptoms included sleep efficiency (β_{BDI Total} = −0.230, P = 0.003; β_cognitive = −0.173, P = 0.030 (β_somatic = -0.255, P = 0.001). In patients with moderate-to-severe OSA, intermittent hypoxia may play a role in somatic rather than cognitive or total depressive symptoms.

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Titel: Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways
Auteurs: Diana A. Chirinos
Indira Gurubhagavatula
Preston Broderick
Julio A. Chirinos
Karen Teff
Thomas Wadden
Greg Maislin
Hassam Saif
Jesse Chittams
Caitlin Cassidy
Alexandra L. Hanlon
Allan I. Pack
Publicatiedatum: 21-06-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2017
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-017-9869-4

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