Skip to main content
Mijn bibliotheek
Shop
Nieuws Boeken Tijdschriften E-learning Web-tv Video Audio
Tips voor Mijn BSL
UITGEBREID ZOEKEN
Inloggen
Top
Quality of Life Research
Gepubliceerd in: Quality of Life Research 9/2017

13-05-2017

Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders

Auteurs: A. Fattori, L. Neri, A. Bellomo, M. Vaggi, C. Mencacci, the ILDE Study Group

Gepubliceerd in: Quality of Life Research | Uitgave 9/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail
    Link delen
publish
Publiceer nu

Abstract

Purpose

Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL.

Methods

Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information.

Results

There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2 = 0.13; p < 0.01) and mental (ω 2 = 0.34; p < 0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders.

Conclusions

Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially independent of the severity of other symptoms, and may represent a specific target of therapy with a strong impact on patients’ functioning and quality of life.
vorige artikel Gratitude mediates quality of life differences between fibromyalgia patients and healthy controls
volgende artikel The relationship between internalized stigma and quality of life among people with mental illness: are self-esteem and sense of coherence sequential mediators?
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
1.
2.
Whiteford, H. A., Ferrari, A. J., Degenhardt, L., Feigin, V., & Vos, T. (2015). The global burden of mental, neurological and substance use disorders: An analysis from the Global Burden of Disease Study 2010. PLoS ONE, 10(2), e0116820.PubMedPubMedCentral
3.
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 593–602.PubMed
4.
Birnbaum, H. G., Kessler, R. C., Kelley, D., Ben-Hamadi, R., Joish, V. N., & Greenberg, P. E. (2010). Employer burden of mild, moderate, and severe major depressive disorder: Mental health services utilization and costs, and work performance. Depression and Anxiety, 27, 78–89.PubMed
5.
Greenberg, P. E., Fournier, A. A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015). The economic burden of adults with major depressive disorder in the United States (2005 and 2010). Journal of Clinical Psychiatry, 76(2), 155–162.
6.
Fattori, A., Neri, L., Aguglia, E., Bellomo, A., Bisogno, A., Camerino, D., et al. (2015). Estimating the impact of workplace bullying: Humanistic and economic burden among workers with chronic medical conditions. BioMed Research International 2015.
7.
Hays, R. D., Wells, K. B., Sherbourne, C. D., Rogers, W., & Spritzer, K. (1995). Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Archives of General Psychiatry, 52, 11–19.PubMed
8.
Pyne, J. M., Patterson, T. L., Kaplan, R. M., Ho, S., Gillin, J. C., Golshan, S., et al. (1997). Preliminary longitudinal assessment of quality of life in patients with major depression. Psychopharmacololy Bulletin, 33, 23–29.
9.
Rapaport, M. H., Clary, C., Fayyad, R., & Endicott, J. (2005). Quality-of-life impairment in depressive and anxiety disorders. American Journal of Psychiatry, 162, 1171–1178.
10.
Schonfeld, W. H., Verboncoeur, C. J., Fifer, S. K., Lipschutz, R. C., Lubeck, D. P., & Buesching, D. P. (1997). The functioning and well-being of patients with unrecognized anxiety disorders and major depressive disorder. Journal of Affective Disorders, 43(2), 105–119.PubMed
11.
Daly, E. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Gaynes, B. N., Warden, D., et al. (2010). Health-related quality of life in depression: A STAR*D report. Annals of Clinical Psychiatry, 22(1), 43–55.PubMed
12.
Keller, M. B., Lavori, P. W., Mueller, T. I., Endicott, J., Coryell, W., Hirschfeld, R. M., et al. (1992). Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. Archives of General Psychiatry, 49, 809–816.PubMed
13.
Schatzberg, A. F. (2002). Major depression: Causes or effects? American Journal of Psychiatry, 159, 1077–1079.
14.
Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., & Mitchell, D. (2010). The role of cognitive impairment in general functioning in major depression. Psychiatry Research, 176, 183–189.PubMed
15.
Castaneda, A. E., Tuulio-Henriksson, A., Marttunen, M., Suvisaari, J., & Lönnqvist, J. (2008). A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. Journal of Affective Disorders, 106, 1–27.PubMed
16.
Smith, D. J., Muir, W. J., & Blackwood, D. H. R. (2006). Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder. Bipolar Disorders, 8, 40–46.PubMed
17.
Egeland, J. B. R., Rund, K., Sundet, N. I., Landrø, A., Asbjørnsen, A., Lund, A., et al. (2003). Attention profile in schizophrenia compared with depression, differential effects of processing speed, selective attention and vigilance. Acta Psychiatrica Scandinavica, 108, 276–284.PubMed
18.
Marazziti, D., Consoli, G., Picchetti, M., Carlini, M., & Faravelli, L. (2010). Cognitive impairment in major depression. European Journal of Pharmacology, 626, 83–86.PubMed
19.
Merriam, E. P., Thase, M. E., Haas, G. L., Keshavan, M. S., & Sweeney, J. A. (1999). Prefrontal cortical dysfunction in depression determined by Wisconsin Card Sorting Test performance. American Journal of Psychiatry, 156, 780–782.
20.
Gualtieri, C. T., & Morgan, D. W. (2008). The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: An unaccounted source of variance in clinical trials. Journal of Clinical Psychiatry, 69(7), 1122–1130.
21.
Kessing, L. V. (1998). Cognitive impairment in the euthymic phase of affective disorder. Psychological Medicine, 28, 1027–1038.PubMed
22.
Austin, M. P., Mitchell, P., & Goodwin, G. M. (2001). Cognitive deficits in depression: possible implications for functional neuropathology. The British Journal of Psychiatry, 178, 200–206.PubMed
23.
Bazin, N., Perruchet, P., De Bonis, M., & Feline, A. (1994). The dissociation of explicit and implicit memory in depressed patients. Psychological Medicine, 24(01), 239–245.PubMed
24.
Calev, A., Korin, Y., Shapira, B., Kugelmass, S., & Lerer, B. (1986). Verbal and non-verbal recall by depressed and euthymic affective patients. Psychological Medicine, 16(04), 789–794.PubMed
25.
Peselow, E. D., Corwin, J., Fieve, R. R., Rotrosen, J., & Cooper, T. B. (1991). Disappearance of memory deficits in outpatient depressives responding to imipramine. Journal of Affective Disorders, 21(3), 173–183.PubMed
26.
Beats, B. C., Sahakian, B. J., & Levy, R. (1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychological Medicine, 26, 591–603.PubMed
27.
Hammar, A., Lund, A., & Hugdahl, K. (2003). Long-lasting cognitive impairment in unipolar major depression: A 6-month follow-up study. Psychiatric Research, 118, 189–196.
28.
Paradiso, S., Lamberty, G. J., Garvey, M. J., & Robinson, R. G. (1997). Cognitive impairment in the euthymic phase of chronic unipolar depression. The Journal of Nervous and Mental Disease, 185, 748–754.PubMed
29.
Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., et al. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. The British Journal of Psychiatry, 186, 32–40.PubMed
30.
Colom, F., Vieta, E., Corbella, B., Martinez-Aran, A., Reinares, M., Benabarre, A., et al. (2000). Clinical factors associated to treatment noncompliance in euthymic bipolar patients. Journal of Clinical Psychiatry, 61, 549–555.
31.
Hirschfeld, R. M. A., Dunner, D. L., Keitner, G., Klein, D. N., Koran, L. M., Kornstein, S. G., et al. (2002). Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination. Biological Psychiatry, 51, 123–133.PubMed
32.
McIntyre, R. S., Cha, D. S., Soczynska, J. K., Woldeyohannes, H. O., Gallaugher, L. A., Kudlow, P., et al. (2013). Cognitive deficits and functional outcomes in major depressive disorder: Determinants, substrates, and treatment interventions. Depression and Anxiety, 30, 515–527.PubMed
33.
Buist-Bouwman, M. A., Ormel, J., de Graaf, R., de Jonge, P., van Sonderen, E., Alonso, J., et al. (2008). Mediators of the association between depression and role functioning. Acta Psychiatrica Scandinavica, 118(6), 451–458.PubMedPubMedCentral
34.
Greenberg, P. E., Kessler, R. C., Birnbaum, H. G., Leong, S. A., Lowe, S. W., Berglund, P. A., et al. (2003). The economic burden of depression in the United States: How did it change between 1990 and 2000? Journal of Clinical Psychiatry, 64(12), 1465–1475.
35.
Naismith, S. L., Longley, W. A., Scott, E. M., & Hickie, I. B. (2007). Disability in major depression related to self-rated and objectively-measured cognitive deficits: A preliminary report. BMC Psychiatry, 7, 32–38.PubMedPubMedCentral
36.
World Health Organization. (1992). The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines. Geneva: World Health Organization.
37.
Montgomery, S. A., & Asberg, M. (1979). A new depression scale designed to be sensitive to change. The British Journal of Psychiatry, 134, 382–389.PubMed
38.
Davidson, J., Turnbull, C. D., Strickland, R., Miller, R., & Graves, K. (1986). The Montgomery-Asberg Depression Scale: Reliability and validity. Acta Psychiatrica Scandinavica, 73, 544–548.PubMed
39.
Parker, R. D., Flint, E. P., Bosworth, H. B., Pieper, C. F., & Steffens, D. C. (2003). A three-factor analytic model of the MADRS in geriatric depression. International Journal of Geriatric Psychiatry, 18, 73–77.PubMed
40.
Koerts, J., Leenders, K. L., Koning, M., Portman, A. T., & Van Beilen, M. (2007). Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson’s disease. European Journal of Neurosciences, 25(10), 3132–3136.
41.
Weintraub, D., Newberg, A. B., Cary, M. S., Siderowf, A. D., Moberg, P. J., Kleiner-Fisman, G., et al. (2005). Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson’s disease. Journal of Nuclear Medicine, 46, 227–232.PubMed
42.
D’Souza, R. M., Strazdins, L., Lim, L. L. Y., Broom, D. H., & Rodgers, B. (2003). Work and health in a contemporary society: Demands, control, and insecurity. Journal of Epidemiology and Community Health, 57, 849–854.PubMedPubMedCentral
43.
Ware, J. E., Kosinski, M., & Keller, S. D. (1996). A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Medical Care, 30, 473–483.
44.
Sivertsen, H., Bjørkløf, G. H., Engedal, K., Selbæk, G., & Helvik, A. (2015). Depression and quality of life in older persons: A review. Dementia and Geriatric Cognitive Disorders, 40, 311–339.PubMed
45.
Wisniewski, S. R., Rush, A. J., Bryan, C., Shelton, R., Trivedi, M. H., Marcus, S., et al. (2007). Comparison of quality of life measures in a depressed population. The Journal of Nervous and Mental Disease, 195(3), 219–225.PubMed
46.
Brazier, J. E., Harper, R., Jones, N. M., O’Cathain, A., Thomas, K. J., Usherwood, T., et al. (1992). Validating the SF-36 health survey questionnaire: new outcome measure for primary care. British Medical Journal, 305(6846), 160–164.PubMedPubMedCentral
47.
48.
Lim, L., Jin, A. Z., & Ng, T. P. (2012). Anxiety and depression, chronic physical conditions, and quality of life in an urban population sample study. Social Psychiatry and Psychiatric Epidemiology, 47, 1047–1053.PubMed
49.
Waltersand, S. J., & Brazier, J. E. (2003). What is the relationship between the minimally important difference and health state utility values? The case of the SF-6D. Health and Quality of Life Outcomes, 1, article 4.
50.
Apolone, G., Mosconi, P., & Quattrocchi, L. (2005). Questionario sullo stato di salute SF-12, versione italiana. Milano: Guerini e Associati.
51.
Camilleri, M., Mangel, A. W., Fehnel, S. E., Drossman, D. A., Mayer, E. A., & Talley, N. J. (2007). Primary endpoints for irritable bowel syndrome trials: A review of performance of endpoints. Clinical Gastroenterology and Hepatology, 5(5), 534–540.PubMed
52.
Bergkvist, L., & Rossiter, J. R. (2007). The predictive validity of multiple-item versus single-item measures of the same constructs. Journal of Marketing Research, 44(2), 175–184.
53.
De Boer, A. G. E. M., Van Lanschot, J. J. B., Stalmeier, P. F. M., Van Sandick, J. W., Hulscher, J. B. F., De Haes, J. C. J. M., et al. (2004). Is a single-item visual analogue scale as valid, reliable and responsive as multi-item scales in measuring quality of life? Quality of Life Research, 13(2), 311–320.PubMed
54.
Bech, P., Tanghøj, P., Cialdella, P., Andersen, H. F., & Pedersen, A. G. (2004). Escitalopram dose–response revisited: an alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depression. International Journal of Neuropsychopharmacology, 7(3), 283–290.
55.
McIntyre, R. S., Lophaven, S., & Olsen, C. K. (2014). A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults. International Journal of Neuropsychopharmacology, 17, 1557–1567.
56.
Greer, T. L., Sunderajan, P., Grannemann, B. D., Kurian, B. T., & Trivedi, M. H. (2014). Does duloxetine improve cognitive function independently of its antidepressant effect in patients with major depressive disorder and subjective reports of cognitive dysfunction? Depression Research and Treatment, 2014.
57.
Katona, C., Hansen, T., & Olsen, C. K. (2012). A randomized, doubleblind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. International Clinical Psychopharmacology, 27, 215–223.PubMed
58.
Mahableshwarkar, A. R., Zajecka, J., Jacobson, W., Chen, Y., & Keefe, R. S. (2015). A randomized, placebo-controlled, active-reference, double-blind, flexible-dose study of the efficacy of vortioxetine on cognitive function in major depressive disorder. Neuropsychopharmacology, 40(8), 2025–2037.PubMedPubMedCentral
59.
Bétry, C., Etiévant, A., Pehrson, A., Sánchez, C., & Haddjeri, N. (2015). Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 58, 38–46.PubMed
60.
Pehrson, A. L., Leiser, S. C., Gulinello, M., Dale, E., Li, Y., Waller, J. A., et al. (2015). Treatment of cognitive dysfunction in major depressive disorder—A review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine. European Journal of Pharmacology, 753, 19–31.PubMed
61.
Lomas, J., Llewellyn, A., Soares, M., Simmonds, M., Wright, K., Eastwood, A., et al. (2016). The clinical and cost effectiveness of vortioxetine for the treatment of a major depressive episode in patients with failed prior antidepressant therapy: A Critique of the Evidence. PharmacoEconomics, 34, 901–912.PubMed
62.
McLaren, M. E., Szymkowicz, S. M., Kirton, J. W., & Dotson, V. M. (2015). Impact of education on memory deficits in subclinical depression. Archives of Clinical Neuropsychology, 30(5), 387–393.PubMedPubMedCentral
63.
Sheline, Y. I., Barch, D. M., Garcia, K., Gersing, K., Pieper, C., Welsh-Bohmer, K., et al. (2006). Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biological Psychiatry, 60(1), 58–65.PubMed
64.
Schrijvers, D., Hulstijn, W., & Sabbe, B. G. C. (2008). Psychomotor symptoms in depression: a diagnostic, pathophysiological and therapeutic tool. Journal of Affective Disorders, 109, 1–20.PubMed
Metagegevens
Titel
Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders
Auteurs
A. Fattori
L. Neri
A. Bellomo
M. Vaggi
C. Mencacci
the ILDE Study Group
Publicatiedatum
13-05-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1595-4

Andere artikelen Uitgave 9/2017

Quality of Life Research 9/2017 Naar de uitgave

Review

Measurement invariance of the Satisfaction with Life Scale: reviewing three decades of research

OriginalPaper

Quality of life among perinatally HIV-affected and HIV-unaffected school-aged and adolescent Ugandan children: a multi-dimensional assessment of wellbeing in the post-HAART era

OriginalPaper

Further evidence on EQ-5D-5L preference inversion: a Brazil/U.S. collaboration

OriginalPaper

The relationship between internalized stigma and quality of life among people with mental illness: are self-esteem and sense of coherence sequential mediators?

OriginalPaper

Clinical setting-based smoking cessation programme and the quality of life in people living with HIV in Austria and Germany

OriginalPaper

Linking of the quality of life in neurological disorders (Neuro-QoL) to the international classification of functioning, disability and health