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Gepubliceerd in: Quality of Life Research 9/2017

13-05-2017

Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders

Auteurs: A. Fattori, L. Neri, A. Bellomo, M. Vaggi, C. Mencacci, the ILDE Study Group

Gepubliceerd in: Quality of Life Research | Uitgave 9/2017

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Abstract

Purpose

Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL.

Methods

Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information.

Results

There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2 = 0.13; p < 0.01) and mental (ω 2 = 0.34; p < 0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders.

Conclusions

Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially independent of the severity of other symptoms, and may represent a specific target of therapy with a strong impact on patients’ functioning and quality of life.
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Metagegevens
Titel
Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders
Auteurs
A. Fattori
L. Neri
A. Bellomo
M. Vaggi
C. Mencacci
the ILDE Study Group
Publicatiedatum
13-05-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1595-4

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