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Gepubliceerd in: Quality of Life Research 4/2011

01-05-2011

Depression and QOL in patients with ALS: how do self-ratings and ratings by relatives differ?

Auteurs: Torsten Grehl, Mirjam Rupp, Paula Budde, Martin Tegenthoff, Heiner Fangerau

Gepubliceerd in: Quality of Life Research | Uitgave 4/2011

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Abstract

Background

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease affecting the motor nervous system and currently lacking effective means of treatment. The focus of ALS treatment therefore lies in palliative treatment from a multidisciplinary team. Published findings regarding affective components and patients’ perceived quality-of-life (QoL) as well as comparative reports of family members/caregivers remain equivocal.

Methods

In this study, 41 ALS patients and their relatives were enrolled in a study employing the 12-item ALS-Depression-Inventory (ADI-12) and the Munich quality-of-life dimensions list (MLDL). The ALS-functional rating scale (ALSFRS-R) was used to evaluate physical disabilities.

Results

The ADI-12 depression scale data identified nine patients with depressive disorders; the patients had satisfactory QoL outcomes on the MLDL. The results did not differ significantly between ALS patients and their relatives.

Conclusions

Thus, in agreement with other studies, QoL and emerging depression do not automatically coincide with patients’ physical impairments of the patients. This “well-being paradox” is currently not well understood, and further studies are needed to optimize the treatment of patients through the course of disease progression.

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Voetnoten
1
For individual questionnaires different numbers of test subjects exist. This is due to the fact that individual patients were unable to complete all questionnaires or could not answer single items.
 
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Metagegevens
Titel
Depression and QOL in patients with ALS: how do self-ratings and ratings by relatives differ?
Auteurs
Torsten Grehl
Mirjam Rupp
Paula Budde
Martin Tegenthoff
Heiner Fangerau
Publicatiedatum
01-05-2011
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9781-7