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03-12-2018 | Original Paper | Uitgave 4/2019

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 4/2019

Auteurs:: Charles Laidi, Jennifer Boisgontier, Amicie de Pierrefeu, Edouard Duchesnay, Sevan Hotier, Marc-Antoine d’Albis, Richard Delorme, Federico Bolognani, Christian Czech, Céline Bouquet, Anouck Amestoy, Julie Petit, Štefan Holiga, Juergen Dukart, Alexandru Gaman, Elie Toledano, Myriam Ly-Le Moal, Isabelle Scheid, Marion Leboyer, Josselin Houenou

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The online version of this article (https://doi.org/10.1007/s10803-018-3807-3) contains supplementary material, which is available to authorized users.

Abstract

Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.

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Supplementary material 1 (DOCX 997 KB)

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Titel: Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism
Auteurs:: Charles Laidi
Jennifer Boisgontier
Amicie de Pierrefeu
Edouard Duchesnay
Sevan Hotier
Marc-Antoine d’Albis
Richard Delorme
Federico Bolognani
Christian Czech
Céline Bouquet
Anouck Amestoy
Julie Petit
Štefan Holiga
Juergen Dukart
Alexandru Gaman
Elie Toledano
Myriam Ly-Le Moal
Isabelle Scheid
Marion Leboyer
Josselin Houenou
Publicatiedatum: 03-12-2018
DOI: https://doi.org/10.1007/s10803-018-3807-3
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 4/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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