Top

Gepubliceerd in:

01-04-2010

De zoektocht naar genen die betrokken zijn bij dwangstoornissen, helpen symptoomdimensies ons verder?

Auteurs: Mevr. dr. Hilga Katerberg, prof. dr. Hans den Boer

Gepubliceerd in: Neuropraxis | Uitgave 2/2010

Samenvatting

Obsessief-compulsieve stoornis (OCS) wordt gekenmerkt door terugkerende gedachten, beelden of ideeën (obsessies) die angst veroorzaken en dwanghandelingen (compulsies) die uitgevoerd worden om deze angst te verminderen. Ongeveer twee tot drie procent van de mensen voldoet tijdens zijn of haar leven aan de diagnose OCS.

vorige artikel Woorden Vooraf

volgende artikel Hoe gaan angst en depressie samen met ADHD?

Alonso, P., Gratacos, M., Menchon, J.M., Saiz-Ruiz, J, Segalas, C., Baca-Garcia, E., Labad, J., Fernandez-Piqueras, J., Real, E., Vaquero, C., Perez, M., Dolengevich, H., Gonzalez, J.R., Bayes, M., de Cid, R., Vallejo, J. & Estivill, X. (2008a). Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessivecompulsive disorder.Biological Psychiatry, 63,619–628.CrossRef

Alonso, P., Gratacosm M., Menchon, J.M., Segalas, C., Gonzalez, J.R., Labad, J., Bayes, M., Real, E., de Cid, R., Pertusa, A., Escarami, G., Vallejo, J. & Estivill, X. (2008b). Genetic susceptibility to obsessivecompulsive hoarding, the contribution of neurotrophic tyrosine kinase receptor type 3 gene.Genes, Brain, and Behavior, 7,778–785.CrossRef

Alsobrook, I.J., Leckman, J.F., Goodman, W.K., Rasmussen, S.A. & Pauls, D.L. (1999). Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores.American Journal of Medical Genetics, 88,669–675.CrossRef

Arnold, P.D., Sicard, T., Burroughs, E., Richter, M.A. & Kennedy, J.L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder.Archives of General Psychiatry, 63,769–776.PubMedCrossRef

Bloch, M.H,, Landeros-Weisenbergerm A., Kelmendin B., Coric, V., Brackenb M.B. & Leckman, J.F. (2006). A systematic review, antipsychotic augmentation with treatment refractory obsessivecompulsive disorder.Molecular Psychiatry, 11,622–632.PubMedCrossRef

Bloch, M.H., Landeros-Weisenberger, A., Sen, S., Dombrowski, P., Kelmendi, B., Coric, V., Pittenger, C. & Leckman, J.F. (2008a). Association of the serotonin transporter polymorphism and obsessive-compulsive disorder, systematic review.American Journal of Medical Genetics B Neuropsychiatrical Genetics, 147B,850–858.CrossRef

Bloch, M.H., Landeros-Weisenberger, A., Rosario, M.C., Pittenger, C. & Leckman, J.F. (2008b). Meta-analysis of the symptom structure of obsessive-compulsive disorder.American Journal of Psychiatry, 165,1532–1542.CrossRef

Cavallini, M.C., Di Bella, D., Siliprandi, F., Malchiodi, F. & Bellodi, L. (2002). Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism.American Journal of Medical Genetics, 114,347–353.PubMedCrossRef

Grootheest, D.S. van, Cath, D.C., Beekman, A.T. & Boomsma, D.I. (2005). Twin studies on obsessive-compulsive disorder, a review.Twin Research and Human Genetics, 8,450–458.PubMed

Grootheest, D.S. van, Boomsma, D.I., Hettema, J.M. & Kendler, K.S. (2008). Heritability of obsessive-compulsive symptom dimensions.American Journal of Medical Genetics B, Neuropsychiatrical Genetics, 147B, 473–478.CrossRef

Chacon, P., Rosario-Campos, M.C., Pauls, D.L., Hounie, A.G., Curi, M., Akkerman, F., Shimabokuro, F.H., de Mathis, M.A., Lopes, A.C., Hasler, G. & Miguel, E.C. (2007). Obsessive-compulsive symptoms in sibling pairs concordant for obsessive-compulsive disorder.American Journal of Medical Genetics B, Neuropsychiatrical Genetics, 144B,551–555.CrossRef

Cullen, B., Brown, C.H., Riddle, M.A., Grados, M., Bienvenu, O.J., Hoehn-Saric, R., Shugar,t Y.Y., Liang, K.Y., Samuels, J., & Nestadt, G. (2007). Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorder.Depression and Anxiety, 24, 130–138.PubMedCrossRef

Dickel, D.E., Veenstra-VanderWeele, J,. Cox, N.J., Wu, X., Fischer, D.J., Etten-Lee, M. van, Himle, J.A., Leventhal, B.L., Cook, E.H, Jr., Hanna, G.L. (2006). Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder.Archives of General Psychiatry, 63,778–785.PubMedCrossRef

Goodman, W.K., Price, L.H., Rasmussen, S.A., Mazure, C., Delgado, P., Heninger, G.R. & Charney DS. 1989a. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Archives of General Psychiatry, 46, 1012–1016.CrossRef

Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR & Charney, D.S. (1989b). The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability.Archives of General Psychiatry, 46, 1006–1011.CrossRef

Hamilton, S.P. (2009). Linkage and association studies of anxiety disorders.Depression and Anxiety, 26,976–983.PubMedCrossRef

Hanna, G.L., Veenstra-VanderWeele, J., Cox, N.J., Boehnke, M., Himle, J.A., Curtis, G.C., Leventhal, B.L. & Cook, E.H. Jr. (2002). Genomewide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands.American Journal of Medical Genetics, 114,541–552.PubMedCrossRef

Hanna, G.L., Veenstra-Vanderweele, J., Coxm N.J., Etten, M. van, Fischer, D.J., Himle, J.A., Bivens, N.C., Wu, X., Roe, C.A. Hennessy, K.A., Dickel, D.E., Leventhal, B.L. & Cook, E.H. Jr. (2007). Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder.Biological Psychiatry, 62,856–862.PubMedCrossRef

Hasler, G., Kazuba, D. & Murphy, D.L. (2006). Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism.American Journal of Medical Genetics, B Neuropsychiatrical Genetics, 141B,403–408.CrossRef

Hasler, G., Pinto, A., Greenberg, B.D., Samuels, J., Fyer, A.J., Pauls, D., Knowles, J.A., McCracken, J.T., Piacentini, J., Riddle, M.A., Rauch, S.L., Rasmussen S.A., Willour, V.L., Grados, M.A, Cullen, B., Bienvenu, O.J., Shugart, Y.Y., Liang, K.Y., Hoehn-Saric, R., Wang, Y., Ronquillo, J., Nestadt, G. & Murphy DL. 2007. Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study.Biological Psychiatry, 61,617–625.PubMedCrossRef

Hemmings, S.M. & Stein, D.J. (2006). The current status of association studies in obsessive-compulsive disorder.Psychiatric Clinics of North America, 29,411–444.PubMedCrossRef

Katerberg, H., Delucchi, K.L., Stewart, S.E., Lochner, C., Denys, D.A.J.P, Stack, D.E., Andresen, M., Kim, S.W., Williams, K.A., Boer, J.A. den, Balkom, A.J.L.M. van, Smit, J.H., Oppen, P. van, Polman, A., Jenike, M.A., Stein, D.J., Mathews, C.A. & Cath, D.C. (in druk). Item-Level Factor analysis and heritability estimates,Behavior genetics.

Katerberg, H., Lochne,r C., Cath, D.C., Jonge, P. de, Bochdanovits, Z., Moolman-Smook, J.C., Hemmings, S.M., Carey, P.D., Stein, D.J., Sondervan, D., Boer, J.A., Balkom, A.J. van, Polman, A., Heutink, P. (2009). The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessivecompulsive disorder (OCD).American Journal of Medical Genetics, B Neuropsychiatrical Genetics, 150B,1050–1062.CrossRef

Katerberg, H., Cath, D.C., Denys, D.A,, Heutink, P., Polman, A., Nieuwerburgh, F.C, van, Deforce, D.L., Bochdanovits, Z., Balkom, A.J. van, Boer, J.A. den. The role of the COMT Val(158) Met polymorphism in the phenotypic expression of obsessivecompulsive disorder.American Journal of Medical Genetics, B Neuropsychiatrical Genetics, 153B,167–176.

Kim, S.J., Lee, H.S. & Kim CH. (2005). Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism.Neuropsychobiology, 52,176–182.PubMedCrossRef

Lin, P.Y. (2007). Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder.Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31,683–689.PubMedCrossRef

Leckman, J.F., Rauch, S.L., Mataix-Cols, D. (2007). Symptom dimensions in obsessive-compulsive disorder, implications for the DSM-V.CNS Spectrums, 12,376–387, 400.

Levinson, D.F. (2006). The genetics of depression, a review.Biological Psychiatry, 60,84–92.PubMedCrossRef

Lochner, C., Hemmings, S.M., Kinnearm C.J., Nelm, D., Seedat, S., Moolman-Smook, J.C. & Stein, D.J. (2008). Cluster analysis of obsessive-compulsive symptomatology, identifying obsessivecompulsive disorder subtypes.Israel Journal of Psychiatry and Related Sciences, 45,164–176.PubMed

Mathews, C.A., Nievergelt, C.M., Azzam, A., Garrido, H., Chavira, D.A., Wessel, J., Bagnarello, M., Reus, V.I. & Schork, N.J. (2007b). Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding.American Journal of Medical Genetics, B Neuropsychiatrical Genetics, 144,174–182.CrossRef

Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O.J., 3rd, Liang, K.Y., LaBuda, M., Walkup, J., Grados, M. & Hoehn-Saric, R. 2000. A family study of obsessive-compulsive disorder.Archives of General Psychiatry, 57,358–363.PubMedCrossRef

Pauls, D.L., Alsobrook, J.P. 2nd, Goodman, W., Rasmussen, S. & Leckman, J.F. (1995). A family study of obsessive-compulsive disorder.American Journal of Psychiatry, 152,76–84.PubMed

Pinto, A., Greenberg, B.D., Grados, M.A., Bienvenu, O.J. 3rd, Samuels, J.F., Murphy, D.L., Hasler, G., Stout, R.L., Rauch, S.L., Shugart. Y.Y., Pauls, D.L., Knowles, J.A., Fyer, A.J., McCracken, J.T., Piacentini, J., Wang, Y., Willourm V.L., Cullen, B., Liang, K.Y., Hoehn-Saric, R., Riddle, M.A., Rasmussen, S.A. & Nestadt, G. (2008). Further development of YBOCS dimensions in the OCD Collaborative Genetics study, symptoms vs. categories.Psychiatry Research, 160,83–93.PubMedCrossRef

Pooley, E.C., Fineberg, N. & Harrison, P.J. (2007). The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessivecompulsive disorder in men, case-control study and meta-analysis.Molecular Psychiatry, 12,556–561.PubMedCrossRef

Poyurovsky, M., Michaelovsky, E., Frisch, A., Knoll, G., Amirm I., Finkelm B., Buniakm F., Hermeshm H. & Weizman, R. (2005). COMT Val158Met polymorphism in schizophrenia with obsessivecompulsive disorder, a case-control study.Neuroscience Letters, 389,21–24.PubMedCrossRef

Real, E., Gratacos, M., Soria, V., Escaramis, G., Alonso, P., Segalas, C., Bayes, M., de Cid, R., Menchon, J.M. & Estivill, X. (2009). A brainderived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder.Biological Psychiatry, 66,674–680.PubMedCrossRef

Samuels, J., Shugart, Y.Y., Grados, M.A., Willour, V.L., Bienvenu, O.J., Greenberg, B.D., Knowles, J.A., McCracken, J.T., Rauch, S.L., Murphy, D.L., Wang, Y., Pinto, A., Fyer, A.J., Piacentini, J., Pauls, D.L., Cullen, B., Rasmussen, S.A., Hoehn-Saric, R., Valle, D., Liang, K.Y., Riddle, M.A. & Nestadt, G. (2007). Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder, results from the OCD Collaborative Genetics Study.American Journal of Psychiatry, 164,493–499.PubMedCrossRef

Shugart, Y.Y., Samuels, J., Willour, V.L., Grados, M.A., Greenberg, B.D., Knowles, J.A., McCracken, J.T., Rauch, S.L., Murphy, D.L., Wang, Y., Pinto, A., Fyer, A.J., Piacentini, J., Pauls, D.L., Cullen, B., Page, J., Rasmussen, S.A., Bienvenu, O.J., Hoehn-Saric, R., Valle, D., Liang, K.Y., Riddle, M.A. & Nestadt, G. (2006). Genomewide linkage scan for obsessive-compulsive disorder, evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q.Molecular Psychiatry, 11,763–770.PubMedCrossRef

Shugart, Y.Y., Wang, Y., Samuels, J.F., Grados, M.A., Greenberg, B.D., Knowles, J.A., McCracken, J.T., Rauch, S.L., Murphy, D.L., Rasmussen, S.A., Cullen, B., Hoehn-Saric, R., Pinto, A., Fyer, A.J., Piacentini, J., Pauls, D.L., Bienvenu, O.J., Riddle, M.A., Liang, K.Y. & Nestadt, G. (2009). A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families.American Journal of Medical Genetics, B Neuropsychiatrical Genetics, 150B,886–892.CrossRef

Skapinakis, P., Papatheodorou, T. & Mavreas, V. (2007). Antipsychotic augmentation of serotonergic antidepressants in treatment-resistant obsessive-compulsive disorder, a meta-analysis of the randomized controlled trials.European Neuropsychopharmacology, 17,79–93.PubMedCrossRef

Stewart, S.E., Platko, J., Fagerness, J., Birns, J., Jenike, E., Smoller, J.W., Perlis, R., Leboyer, M., Delorme, R., Chabane, N., Rauch, S.L., Jenike, M.A., Pauls, D.L. (2007). A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.Archives of General Psychiatry, 64,209–214.PubMedCrossRef

Wendland, J.R., Kruse, M.R., Cromer, K.R., Murphy, D.L. (2007). A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder.Neuropsychopharmacology, 32,2543–2551.PubMedCrossRef

Wendland, J.R., Moya, P.R., Timpano, K.R., Anavitarte, A.P., Kruse, M.R., Wheaton, M.G., Ren-Patterson, R.F. & Murphy, D.L. (2009). A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.Archives of General Psychiatry, 66,408–416.PubMedCrossRef

Willour, V.L., Yao Shugart, Y., Samuels, J., Grados, M., Cullen, B., Bienvenu, O.J. 3rd, Wang, Y., Liang, K.Y., Valle, D., Hoehn-Saric, R., Riddle, M. & Nestadt, G. (2004). Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder.American Journal of Human Genetics, 75,508–513.PubMedCrossRef

Zhang, H., Leckman, J.F., Pauls, D.L., Tsai, C.P., Kidd, K.K. & Campos, M.R. (2002). Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome.American Journal of Human Genetics, 70,896–904.PubMedCrossRef

Titel: De zoektocht naar genen die betrokken zijn bij dwangstoornissen, helpen symptoomdimensies ons verder?
Auteurs: Mevr. dr. Hilga Katerberg
prof. dr. Hans den Boer
Publicatiedatum: 01-04-2010
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Neuropraxis / Uitgave 2/2010
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI: https://doi.org/10.1007/s12474-010-0007-0

Bohn Stafleu van Loghum

De zoektocht naar genen die betrokken zijn bij dwangstoornissen, helpen symptoomdimensies ons verder?

Samenvatting

Andere artikelen Uitgave 2/2010

Zelfmoord

Woorden Vooraf

Hoe gaan angst en depressie samen met ADHD?

Signalement

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Samenvatting

Log in om toegang te krijgen

Zelfmoord

Woorden Vooraf

Hoe gaan angst en depressie samen met ADHD?

Signalement