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01-08-2013 | Artikelen

De ziekte van Parkinson: van geremde motoriek tot ontremde impulsen

Auteurs: Drs. Chris Vriend, Dr. Ysbrand van der Werf, Dr. Tommy Pattij, Dr. Pieter Voorn, prof dr. Jan Booij, mw. drs. Sonja Rutten, prof dr. Henk Berendse, mw. dr Odile van den Heuvel

Gepubliceerd in: Neuropraxis | Uitgave 4/2013

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Impulscontrolestoornissen (ICS) zijn relatief vaak voorkomende stoornissen bij de ziekte van Parkinson (ZvP) die gekarakteriseerd kunnen worden als het onvermogen om bepaalde (vaak schadelijke of nadelige) impulsen te onderdrukken. ICS bij de ZvP kunnen ernstige sociaal-maatschappelijke gevolgen hebben voor zowel patiënt als mantelzorger. Het is daarom belangrijk om patiënten die het risico lopen ICS te ontwikkelen vroegtijdig te identificeren. Het ontwikkelen van ICS bij de ZvP lijkt afhankelijk te zijn van een interactie tussen een individuele predispositie en behandeling met dopaminerge medicatie. Hoewel er een aantal demografische en klinische risicofactoren bekend zijn, is de pathofysiologie van ICS nog niet volledig ontrafeld. Er zijn sterke aanwijzingen dat disfunctie van het limbische fronto-striatale circuit hieraan ten grondslag ligt. Uit recente studies komt naar voren dat er ook pathofysiologische overeenkomsten bestaan tussen ICS en depressie bij de ZvP en dat het neurodegeneratieve proces van de ZvP bij beide een belangrijke rol speelt. In dit review-artikel geven we een overzicht van de recente literatuur over de neurobiologie van ICS bij de ZvP en bespreken we potentiële neurobiologische risicofactoren en de daaruit voortkomende klinische implicaties.

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Titel: De ziekte van Parkinson: van geremde motoriek tot ontremde impulsen
Auteurs: Drs. Chris Vriend
Dr. Ysbrand van der Werf
Dr. Tommy Pattij
Dr. Pieter Voorn
prof dr. Jan Booij
mw. drs. Sonja Rutten
prof dr. Henk Berendse
mw. dr Odile van den Heuvel
Publicatiedatum: 01-08-2013
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Neuropraxis / Uitgave 4/2013
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI: https://doi.org/10.1007/s12474-013-0020-1

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