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Gepubliceerd in: Tijdschrift voor Gerontologie en Geriatrie 3/2018

27-02-2018

De relatie tussen apathie, depressie en cognitief functioneren bij patiënten met MCI en dementie

Auteurs: Robin Vloeberghs, Esther M. Opmeer, Peter P. De Deyn, Sebastiaan Engelborghs, Ellen E. De Roeck

Gepubliceerd in: Tijdschrift voor Gerontologie en Geriatrie | Uitgave 3/2018

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Samenvatting

Achtergrond

Apathie wordt bij patiënten met dementie en lichte cognitieve problemen (MCI) vaak gezien als een symptoom van depressie, maar anderen beschrijven apathie en depressie als aparte stoornissen. Voor de correcte behandeling is onderscheid tussen beide echter noodzakelijk. Mogelijk hebben deze stoornissen een verschillende relatie met cognitie en zou dit onderscheid van diagnostisch belang kunnen zijn. Dit is echter nog niet éénduidig bewezen. In dit onderzoek tonen we aan in welke mate apathie en depressie voorkomt bij patiënten met MCI en dementie en onderzochten we de relatie met cognitieve maten binnen de MCI-groep.

Methode

Bij 117 cognitief gezonde controles (GC), 97 deelnemers met MCI en 50 deelnemers met een beginnende dementie (DEM) werd de Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) afgenomen. Daarnaast werden de apathie evaluatie schaal klinische versie (AES-C, grenswaarde 38) en de geriatrische depressie schaal (GDS, grenswaarde 11) afgenomen.

Resultaten

Het aantal deelnemers met apathie was hoger naarmate er sprake was van een meer gevorderd stadium van cognitieve klachten met respectievelijk 3,4 %; 10,4 % en 41,5 % van de deelnemers in de GC-, MCI- en DEM-groep. De prevalentie van geïsoleerde depressieve symptomen was het hoogst in de MCI-groep (18,8 %). Correlatieanalyses binnen de MCI-groep tonen aan dat apathie geassocieerd is, met zwakker presteren op inprenting, aandacht en het algemeen cognitief functioneren.

Conclusie

Apathie en depressieve symptomen komen in verschillende mate voor bij GC, MCI en DEM en zijn in de MCI-groep geassocieerd met achteruitgang in verschillende cognitieve domeinen.
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Metagegevens
Titel
De relatie tussen apathie, depressie en cognitief functioneren bij patiënten met MCI en dementie
Auteurs
Robin Vloeberghs
Esther M. Opmeer
Peter P. De Deyn
Sebastiaan Engelborghs
Ellen E. De Roeck
Publicatiedatum
27-02-2018
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Tijdschrift voor Gerontologie en Geriatrie / Uitgave 3/2018
Print ISSN: 0167-9228
Elektronisch ISSN: 1875-6832
DOI
https://doi.org/10.1007/s12439-018-0248-6