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30-08-2017 | Artikel

De impact van hubdisfunctioneren op cognitie

Auteurs: Jolanda Derks, Linda Douw

Gepubliceerd in: Neuropraxis | Uitgave 5/2017

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Samenvatting

De hersenen worden steeds vaker benaderd vanuit netwerkperspectief, waarbij de verbindingen tussen functionele hersengebieden en hun karakteristieke patronen in kaart gebracht worden. Belangrijke kenmerken van het hersennetwerk zijn optimale integratie en segregatie (het zogeheten small-worldprincipe). Daarnaast bevat het hersennetwerk een aantal gebieden die een centrale rol innemen in het netwerk, de zogenaamde hubs. Disfunctioneren van deze hubs is in verband gebracht met veel neurologische aandoeningen. Op basis van de resultaten van twee recente studies wordt het effect gedemonstreerd van een hersenbeschadiging op het falen van hersennetwerken door overbelasting van hubs (hub-overload). We beschrijven hoe de mate van hub-overload samenhangt met cognitief functioneren en zelfs postoperatieve veranderingen kan voorspellen.
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Metagegevens
Titel
De impact van hubdisfunctioneren op cognitie
Auteurs
Jolanda Derks
Linda Douw
Publicatiedatum
30-08-2017
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 5/2017
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-017-0164-5

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