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Gepubliceerd in: Neuropraxis 1/2010

01-02-2010

De cognitieve en neurale basis van hallucinaties bij schizofrenie

Auteur: Ans Vercammen

Gepubliceerd in: Neuropraxis | Uitgave 1/2010

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Samenvatting

Hallucinaties zijn een bijzonder menselijk fenomeen. Beschrijvingen van hallucinatieachtige fenomenen en ‘visioenen’ duiken regelmatig op in de literatuur, maar pas in de negentiende eeuw werden de eerste systematische wetenschappelijke studies gerapporteerd. De Franse psychiater Esquirol heeft hierin een zeer belangrijke rol gespeeld. Hij definieerde hallucinaties als ‘een sterke overtuiging van een sensorische ervaring, terwijl er geen extern object is dat het zintuig op de daarbij passende manier beïnvloedt’. Vandaag accepteert de wetenschappelijke wereld dat hallucinaties ontstaan door het foutief toewijzen van intern gegenereerde informatie aan een externe bron. De precieze onderliggende cognitief-emotionele processen die aan de basis liggen van deze denkfout zijn echter tot op heden niet helemaal duidelijk.
Literatuur
go back to reference Aleman, A., Formisano, E., Koppenhagen, H., Hagoort, P., de Haan, E.H. & Kahn, R.S. (2005). The functional neuroanatomy of metrical stress evaluation of perceived and imagined spoken words. Cerebral Cortex, 15, 221–228.PubMedCrossRef Aleman, A., Formisano, E., Koppenhagen, H., Hagoort, P., de Haan, E.H. & Kahn, R.S. (2005). The functional neuroanatomy of metrical stress evaluation of perceived and imagined spoken words. Cerebral Cortex, 15, 221–228.PubMedCrossRef
go back to reference Allen, P., Aleman, A. & McGuire, P.K. (2007). Inner speech models of auditory verbal hallucinations: evidence from behavioural and neuroimaging studies. International Review of Psychiatry, 19, 407–415.PubMedCrossRef Allen, P., Aleman, A. & McGuire, P.K. (2007). Inner speech models of auditory verbal hallucinations: evidence from behavioural and neuroimaging studies. International Review of Psychiatry, 19, 407–415.PubMedCrossRef
go back to reference Behrendt, R.P. (1998). Underconstrained perception: a theoretical approach to the nature and function of verbal hallucinations. Comprehensive Psychiatry, 39, 236–248.PubMedCrossRef Behrendt, R.P. (1998). Underconstrained perception: a theoretical approach to the nature and function of verbal hallucinations. Comprehensive Psychiatry, 39, 236–248.PubMedCrossRef
go back to reference Bleich-Cohen, M., Hendler, T., Kotler, M. & Strous, R.D. (2009). Reduced language lateralization in first-episode schizophrenia: An fmri index of functional asymmetry. Psychiatry Research, 171, 82–93.PubMedCrossRef Bleich-Cohen, M., Hendler, T., Kotler, M. & Strous, R.D. (2009). Reduced language lateralization in first-episode schizophrenia: An fmri index of functional asymmetry. Psychiatry Research, 171, 82–93.PubMedCrossRef
go back to reference Fitzgerald, P.B., Sritharan, A., Benitez, J., Daskalakis, Z.J., Jackson, G., Kulkarni, J. et al. (2007). A preliminary fmri study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rtms. Psychiatry Research, 155, 83–88.PubMedCrossRef Fitzgerald, P.B., Sritharan, A., Benitez, J., Daskalakis, Z.J., Jackson, G., Kulkarni, J. et al. (2007). A preliminary fmri study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rtms. Psychiatry Research, 155, 83–88.PubMedCrossRef
go back to reference Ford, J.M., Mathalon, D.H., Whitfield, S., Faustman, W.O. & Roth, W. T. (2002). Reduced communication between frontal and temporal lobes during talking in schizophrenia. Biological Psychiatry, 51, 485–492.PubMedCrossRef Ford, J.M., Mathalon, D.H., Whitfield, S., Faustman, W.O. & Roth, W. T. (2002). Reduced communication between frontal and temporal lobes during talking in schizophrenia. Biological Psychiatry, 51, 485–492.PubMedCrossRef
go back to reference Greicius, M.D., Krasnow, B., Reiss, A.L. & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences U.S.A, 100, 253–258.CrossRef Greicius, M.D., Krasnow, B., Reiss, A.L. & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences U.S.A, 100, 253–258.CrossRef
go back to reference Grossberg, S. (2000). How hallucinations may arise from brain mechanisms of learning, attention, and volition. Journal of the International Neuropsychological Society, 6, 583–592.PubMedCrossRef Grossberg, S. (2000). How hallucinations may arise from brain mechanisms of learning, attention, and volition. Journal of the International Neuropsychological Society, 6, 583–592.PubMedCrossRef
go back to reference Gusnard, D.A. & Raichle, M.E. (2001). Searching for a baseline: functional imaging and the resting human brain. National Review of Neuroscience, 2, 685–694.CrossRef Gusnard, D.A. & Raichle, M.E. (2001). Searching for a baseline: functional imaging and the resting human brain. National Review of Neuroscience, 2, 685–694.CrossRef
go back to reference Hoffman, R.E., Boutros, N.N., Berman, R.M., Roessler, E., Belger, A., Krystal, J.H. et al. (1999). Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated ‘voices’. Biological Psychiatry, 46, 130–132.PubMedCrossRef Hoffman, R.E., Boutros, N.N., Berman, R.M., Roessler, E., Belger, A., Krystal, J.H. et al. (1999). Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated ‘voices’. Biological Psychiatry, 46, 130–132.PubMedCrossRef
go back to reference Hoffman, R.E., Boutros, N.N., Hu, S., Berman, R.M., Krystal, J.H. & Charney, D.S. (2000). Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet, 355, 1073–1075.PubMedCrossRef Hoffman, R.E., Boutros, N.N., Hu, S., Berman, R.M., Krystal, J.H. & Charney, D.S. (2000). Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet, 355, 1073–1075.PubMedCrossRef
go back to reference Hoffman, R.E., Hawkins, K.A., Gueorguieva, R., Boutros, N.N., Rachid, F., Carroll, K. et al. (2003). Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry, 60, 49–56.PubMedCrossRef Hoffman, R.E., Hawkins, K.A., Gueorguieva, R., Boutros, N.N., Rachid, F., Carroll, K. et al. (2003). Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry, 60, 49–56.PubMedCrossRef
go back to reference Horacek, J., Brunovsky, M., Novak, T., Skrdlantova, L., Klirova, M., Bubenikova-Valesova, V. et al. (2007). Effect of low-frequency rtms on electromagnetic tomography (loreta) and regional brain metabolism (pet) in schizophrenia patients with auditory hallucinations. Neuropsychobiology, 55, 132–142.PubMedCrossRef Horacek, J., Brunovsky, M., Novak, T., Skrdlantova, L., Klirova, M., Bubenikova-Valesova, V. et al. (2007). Effect of low-frequency rtms on electromagnetic tomography (loreta) and regional brain metabolism (pet) in schizophrenia patients with auditory hallucinations. Neuropsychobiology, 55, 132–142.PubMedCrossRef
go back to reference Launay, G. & Slade, P. (1981). The measurement of hallucinatory predisposition in male and female prisoners. Personality and Individual Differences, 2, 221–234.CrossRef Launay, G. & Slade, P. (1981). The measurement of hallucinatory predisposition in male and female prisoners. Personality and Individual Differences, 2, 221–234.CrossRef
go back to reference Lawrie, S.M., Buechel, C., Whalley, H.C., Frith, C.D., Friston, K.J. & Johnstone, E.C. (2002). Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biological Psychiatry, 51, 1008–1011.PubMedCrossRef Lawrie, S.M., Buechel, C., Whalley, H.C., Frith, C.D., Friston, K.J. & Johnstone, E.C. (2002). Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biological Psychiatry, 51, 1008–1011.PubMedCrossRef
go back to reference Lennox, B.R., Park, S.B., Medley, I., Morris, P.G. & Jones, P.B. (2000). The functional anatomy of auditory hallucinations in schizophrenia. Psychiatry Research, 100, 13–20.PubMedCrossRef Lennox, B.R., Park, S.B., Medley, I., Morris, P.G. & Jones, P.B. (2000). The functional anatomy of auditory hallucinations in schizophrenia. Psychiatry Research, 100, 13–20.PubMedCrossRef
go back to reference Li, X., Branch, C.A., Ardekani, B.A., Bertisch, H., Hicks, C. & DeLisi, L. E. (2007). fmri study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk. Schizophrenia Research, 96, 14–24.PubMedCrossRef Li, X., Branch, C.A., Ardekani, B.A., Bertisch, H., Hicks, C. & DeLisi, L. E. (2007). fmri study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk. Schizophrenia Research, 96, 14–24.PubMedCrossRef
go back to reference Maguire, E.A., Woollett, K. & Spiers, H.J. (2006). London taxi drivers and bus drivers: a structural mri and neuropsychological analysis. Hippocampus, 16, 1091–1101.PubMedCrossRef Maguire, E.A., Woollett, K. & Spiers, H.J. (2006). London taxi drivers and bus drivers: a structural mri and neuropsychological analysis. Hippocampus, 16, 1091–1101.PubMedCrossRef
go back to reference McGuire, P.K., Shah, G.M., & Murray, R.M. (1993). Increased blood flow in Broca’s area during auditory hallucinations in schizophrenia. Lancet, 342, 703–706.PubMedCrossRef McGuire, P.K., Shah, G.M., & Murray, R.M. (1993). Increased blood flow in Broca’s area during auditory hallucinations in schizophrenia. Lancet, 342, 703–706.PubMedCrossRef
go back to reference Mechelli, A., Friston, K.J., Frackowiak, R.S. & Price, C.J. (2005). Structural covariance in the human cortex. Journal of Neuroscience, 25, 8303–8310.PubMedCrossRef Mechelli, A., Friston, K.J., Frackowiak, R.S. & Price, C.J. (2005). Structural covariance in the human cortex. Journal of Neuroscience, 25, 8303–8310.PubMedCrossRef
go back to reference Mitelman, S.A., Buchsbaum, M.S., Brickman, A.M. & Shihabuddin, L. (2005). Cortical intercorrelations of frontal area volumes in schizophrenia. Neuroimage, 27, 753–770.PubMedCrossRef Mitelman, S.A., Buchsbaum, M.S., Brickman, A.M. & Shihabuddin, L. (2005). Cortical intercorrelations of frontal area volumes in schizophrenia. Neuroimage, 27, 753–770.PubMedCrossRef
go back to reference Modinos, G., Vercammen, A., Mechelli, A., Knegtering H., McGuire, P.K. & Aleman, A. (2009). Structural covariance in the hallucinating brain: a voxel-based morphometry study. Journal of Psychiatry & Neuroscience, 34, 465–469. Modinos, G., Vercammen, A., Mechelli, A., Knegtering H., McGuire, P.K. & Aleman, A. (2009). Structural covariance in the hallucinating brain: a voxel-based morphometry study. Journal of Psychiatry & Neuroscience, 34, 465–469.
go back to reference Pascual-Leone, A., Davey, N., Rothwell, J., Wassermann, E.M. & Puri, B. K. (2002). Handbook of transcranial magnetic stimulation. (1e dr.) Londen (uk): Arnold. Pascual-Leone, A., Davey, N., Rothwell, J., Wassermann, E.M. & Puri, B. K. (2002). Handbook of transcranial magnetic stimulation. (1e dr.) Londen (uk): Arnold.
go back to reference Plaze, M., Bartres-Faz, D., Martinot, J.L., Januel, D., Bellivier, F., de Beaurepaire R. et al. (2006). Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients. Schizophrenia Research, 87, 109–115.PubMedCrossRef Plaze, M., Bartres-Faz, D., Martinot, J.L., Januel, D., Bellivier, F., de Beaurepaire R. et al. (2006). Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients. Schizophrenia Research, 87, 109–115.PubMedCrossRef
go back to reference Shergill, S.S., Brammer, M.J., Williams, S.C., Murray, R.M. & McGuire, P.K. (2000). Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Archives of General Psychiatry, 57, 1033–1038.PubMedCrossRef Shergill, S.S., Brammer, M.J., Williams, S.C., Murray, R.M. & McGuire, P.K. (2000). Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Archives of General Psychiatry, 57, 1033–1038.PubMedCrossRef
go back to reference Sommer, I.E., Ramsey, N.F. & Kahn, R.S. (2001). Language lateralization in schizophrenia, an fmri study. Schizophrenia Research, 52, 57–67.PubMedCrossRef Sommer, I.E., Ramsey, N.F. & Kahn, R.S. (2001). Language lateralization in schizophrenia, an fmri study. Schizophrenia Research, 52, 57–67.PubMedCrossRef
go back to reference Vercammen, A. (2009). Cognitive and neural processes of auditory-verbal hallucinations in schizophrenia: Evidence from behavioral and neuroimaging experiments. Faculteit Medische Wetenschappen, Universiteit Groningen. Proefschrift. Vercammen, A. (2009). Cognitive and neural processes of auditory-verbal hallucinations in schizophrenia: Evidence from behavioral and neuroimaging experiments. Faculteit Medische Wetenschappen, Universiteit Groningen. Proefschrift.
go back to reference Vercammen, A. & Aleman, A. (2008). Semantic expectations can induce false perceptions in hallucination prone individuals. Schizophrenia Bulletin, 2008 Jun 17. Epub ahead of print. Vercammen, A. & Aleman, A. (2008). Semantic expectations can induce false perceptions in hallucination prone individuals. Schizophrenia Bulletin, 2008 Jun 17. Epub ahead of print.
go back to reference Vercammen, A. de Haan, E.H. & Aleman, A. (2008). Hearing a voice in the noise: auditory hallucinations and speech perception. Psychological Medicine, 38,8, 1177–1184. Epub 2007 Dec 13.PubMedCrossRef Vercammen, A. de Haan, E.H. & Aleman, A. (2008). Hearing a voice in the noise: auditory hallucinations and speech perception. Psychological Medicine, 38,8, 1177–1184. Epub 2007 Dec 13.PubMedCrossRef
go back to reference Vercammen, A., Knegtering, H., Bruggeman, R., Westenbroek, H.M., Jenner, J.A., Slooff, C.J., Wunderink, L. & Aleman, A. (2009). Effects of bilateral transcranial magnetic stimulation on treatment resistant hallucinations in schizophrenia: a randomized controlled trial. Schizophrenia Research, 114,1–3, 172–179. Epub 2009 Aug 13.PubMedCrossRef Vercammen, A., Knegtering, H., Bruggeman, R., Westenbroek, H.M., Jenner, J.A., Slooff, C.J., Wunderink, L. & Aleman, A. (2009). Effects of bilateral transcranial magnetic stimulation on treatment resistant hallucinations in schizophrenia: a randomized controlled trial. Schizophrenia Research, 114,1–3, 172–179. Epub 2009 Aug 13.PubMedCrossRef
go back to reference Vercammen, A., Knegtering, H., Boer, J.A. den, Liemburg, E.J. & Aleman, A. (Geaccepteerd voor publicatie in Biological Psychiatry). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area. Vercammen, A., Knegtering, H., Boer, J.A. den, Liemburg, E.J. & Aleman, A. (Geaccepteerd voor publicatie in Biological Psychiatry). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area.
go back to reference Zhang, Z., Shi, J., Yuan, Y., Hao, G., Yao, Z. & Chen, N. (2008). Relationship of auditory verbal hallucinations with cerebral asymmetry in patients with schizophrenia: an event-related fmri study. Journal of Psychiatric Research, 42, 477–486.PubMedCrossRef Zhang, Z., Shi, J., Yuan, Y., Hao, G., Yao, Z. & Chen, N. (2008). Relationship of auditory verbal hallucinations with cerebral asymmetry in patients with schizophrenia: an event-related fmri study. Journal of Psychiatric Research, 42, 477–486.PubMedCrossRef
Metagegevens
Titel
De cognitieve en neurale basis van hallucinaties bij schizofrenie
Auteur
Ans Vercammen
Publicatiedatum
01-02-2010
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 1/2010
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-010-0002-5

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