Introduction
Methods
Patient population and study protocol
MRI acquisition
Acquisition of aortic dimensions
Acquisition of aortic PWV
Image analysis
Analysis of aortic dimensions
Analysis of aortic PWV
Statistical analysis
Results
Demographics
| |
Male/female | 28 (70 %)/12 (30 %) |
Age at MRI (years) | 59 ± 13 |
Clinical characteristics
| |
Height (cm) | 180 ± 10 |
Body mass index (kg/m2) | 27 ± 4 |
Body surface area (m2) | 2.1 ± 0.2 |
Brachial blood pressure (mmHg)
| |
Systolic | 134 ± 20 |
Diastolic | 79 ± 11 |
Heart rate (beats/minute) | 66 ± 10 |
MRI assessed LV dimensions and function
| |
EDV (ml) | 164 ± 38 |
EDV/BSA (ml/m2) | 80 ± 19 |
ESV (ml) | 69 ± 23 |
ESV/BSA (ml/m2) | 34 ± 12 |
Ejection fraction (%) | 62 ± 5 |
Cardiovascular risk factors
| |
Hypertensiona
| 27 (68 %) |
Current smoker | 7 (18 %) |
Hypercholesterolaemiab
| 16 (40 %) |
Diabetes mellitus | 1 (3 %) |
Obesityc
| 7 (18 %) |
Previous myocardial infarction | 4 (10 %) |
Cardiovascular medication
| |
β-blocker | 17 (58 %) |
ACE inhibitor | 21 (53 %) |
Anticoagulants | 16 (40 %) |
Statins | 13 (33 %) |
Aortic diameter
Aortic segment | Diameters (maximal luminal diameter, mm) | Diameters (mean luminal diameter, mm) | PWV (m/s) | PWV, Number of patients analysed |
---|---|---|---|---|
S1: Ascending aorta | 39.4 ± 5.3 | 34.8 ± 4.2 | 7.7 ± 4.8 | 39 |
S2: Aortic arch | 28.7 ± 3.2 | 29.4 ± 2.7 | 7.7 ± 5.6 | 37 |
S3: Thoracic descending aorta | 26.6 ± 5.7 | 24.3 ± 2.7 | 8.5 ± 3.9 | 40 |
S4: Suprarenal abdominal aorta | 25 ± 3 | 22.4 ± 2.6 | 8.3 ± 4.0 | 40 |
S5: Infrarenal abdominal aorta | 18.5 ± 3.2 | 17.2 ± 3.7 | 8.3 ± 4.0 | 38 |
PWV values
Coupling between PWV and aortic diameters
N
| Aortic Segment | Incidence of increased | Sensitivity (CI) | Specificity (CI) | Positive predictive value (CI) | Negative predictive value (CI) | |
---|---|---|---|---|---|---|---|
PWV | Diameter | ||||||
39 | S1: Ascending aorta | 8 (21 %) | 15 (38 %) | 13 % (2–42 %) | 75 % (53–89 %) | 25 % (4–64 %) | 58 % (39–75) |
37 | S2: Aortic arch | 11 (28 %) | 6 (16 %) | 17 % (1–64 %) | 68 % (49–83 %) | 9 % (0–43) | 81 % (60–93) |
40 | S3: Thoracic descending aorta | 7 (18 %) | 4 (10 %) | 75 % (22–99 %) | 89 % (73–96 %) | 43 % (12–80 %) | 97 % (82–100 %) |
40 | S4: Suprarenal abdominal aorta | 6 (15 %) | 2 (5 %) | 0 % (0–80 %) | 84 % (68–93 %) | 0 % (0–48 %) | 94 % (79–99 %) |
38 | S5: Infrarenal abdominal aorta | 4 (10 %) | 1 (3 %) | 100 % (5–100 %) | 92 % (77–98 %) | 25 % (1–78 %) | 100 % (87–100 %) |