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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2015

01-05-2015 | Original Paper

Cortical Variability in the Sensory-Evoked Response in Autism

Auteurs: Sarah M. Haigh, David J. Heeger, Ilan Dinstein, Nancy Minshew, Marlene Behrmann

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2015

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Abstract

Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.
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Metagegevens
Titel
Cortical Variability in the Sensory-Evoked Response in Autism
Auteurs
Sarah M. Haigh
David J. Heeger
Ilan Dinstein
Nancy Minshew
Marlene Behrmann
Publicatiedatum
01-05-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2276-6

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