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01-05-2015 | Original Paper | Uitgave 5/2015

Cortical Variability in the Sensory-Evoked Response in Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 5/2015

Auteurs:: Sarah M. Haigh, David J. Heeger, Ilan Dinstein, Nancy Minshew, Marlene Behrmann

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The online version of this article (doi:10.1007/s10803-014-2276-6) contains supplementary material, which is available to authorized users.

Abstract

Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.

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Titel: Cortical Variability in the Sensory-Evoked Response in Autism
Auteurs:: Sarah M. Haigh
David J. Heeger
Ilan Dinstein
Nancy Minshew
Marlene Behrmann
Publicatiedatum: 01-05-2015
DOI: https://doi.org/10.1007/s10803-014-2276-6
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 5/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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Cortical Variability in the Sensory-Evoked Response in Autism

Electronic supplementary material

Abstract

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