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Quality of Life Research
Gepubliceerd in: Quality of Life Research 3/2020

31-10-2019

Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease

Auteurs: Cristina Esquinas, Maria A. Ramon, Alexa Nuñez, Jesús Molina, José A. Quintano, Miguel Roman-Rodríguez, Karlos Naberan, Carl Llor, Carlos Roncero, Marc Miravitlles, Miriam Barrecheguren

Gepubliceerd in: Quality of Life Research | Uitgave 3/2020

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Abstract

Purpose

Impaired health-related quality of life (HRQoL) is associated with poor health outcomes in chronic obstructive pulmonary disease (COPD). The aim of this study was to determine health utilities in patients with COPD and to identify the variables with the greatest impact.

Methods

This is a pooled analysis of data from 4 observational studies performed in stable COPD patients. Evaluation of patient HRQoL utilities was performed using the Spanish version of the self-administered EuroQoL 5 Dimensions (EQ-5D) questionnaire. EQ-5D utilities were described and compared according to several markers of disease severity.

Results

6198 patients reported a mean (SD) EQ-5D index of 0.67 (0.26). A linear dose response relationship between EQ-5D utility and modified Medical Research Council (mMRC) score, forced expiratory volume in one 1 s (% predicted), COPD hospital admissions in the previous year, self-reported daily walking time, Charlson index, body mass index, obstruction, dyspnoea and exacerbation (BODEx) index, COPD assessment test (CAT), hospital anxiety and depression scale was observed (p for trend < 0.001). In multivariate analysis, patients reporting lower utility values were those with more dyspnoea, more comorbidities, using long-term oxygen therapy, with previous hospitalisations due to a COPD exacerbation and higher (worse) CAT score.

Conclusion

HRQoL measures such as EQ-5D can assist clinicians to understand the impact of respiratory disease on COPD patients.
vorige artikel Characterizing health state utilities associated with Duchenne muscular dystrophy: a systematic review
volgende artikel The construct validity and responsiveness of the EQ-5D-5L, AQL-5D and a bespoke TTO in acute asthmatics
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Metagegevens
Titel
Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease
Auteurs
Cristina Esquinas
Maria A. Ramon
Alexa Nuñez
Jesús Molina
José A. Quintano
Miguel Roman-Rodríguez
Karlos Naberan
Carl Llor
Carlos Roncero
Marc Miravitlles
Miriam Barrecheguren
Publicatiedatum
31-10-2019
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 3/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-019-02340-4

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