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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2009

01-06-2009 | Original Paper

Corpus Callosum Volume and Neurocognition in Autism

Auteurs: Christopher J. Keary, Nancy J. Minshew, Rahul Bansal, Dhruman Goradia, Serguei Fedorov, Matcheri S. Keshavan, Antonio Y. Hardan

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2009

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Abstract

The corpus callosum has recently been considered as an index of interhemispheric connectivity. This study applied a novel volumetric method to examine the size of the corpus callosum in 32 individuals with autism and 34 age-, gender- and IQ-matched controls and to investigate the relationship between this structure and cognitive measures linked to interhemispheric functioning. Participants with autism displayed reductions in total corpus callosum volume and in several of its subdivisions. Relationships were also observed between volumetric alterations and performance on several cognitive tests including the Tower of Hanoi test. These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity.

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Metagegevens
Titel
Corpus Callosum Volume and Neurocognition in Autism
Auteurs
Christopher J. Keary
Nancy J. Minshew
Rahul Bansal
Dhruman Goradia
Serguei Fedorov
Matcheri S. Keshavan
Antonio Y. Hardan
Publicatiedatum
01-06-2009
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-009-0689-4