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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2006

01-08-2006 | Original Paper

Corpus Callosum Morphometrics in Young Children with Autism Spectrum Disorder

Auteurs: Inbal Boger-Megiddo, Dennis W. W. Shaw, Seth D. Friedman, Bobbi F. Sparks, Alan A. Artru, Jay N. Giedd, Geraldine Dawson, Stephen R. Dager

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2006

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Abstract

This study assessed midsagittal corpus callosum cross sectional areas in 3–4 year olds with autism spectrum disorder (ASD) compared to typically developing (TD) and developmentally delayed (DD) children. Though not different in absolute size compared to TD, ASD callosums were disproportionately small adjusted for increased ASD cerebral volume. ASD clinical subgroup analysis revealed greater proportional callosum reduction in the more severely affected autistic disorder (AD) than in pervasive developmental disorder-not otherwise specified (PDD-NOS) children. DD children had smaller absolute callosums than ASD and TD. Subregion analysis revealed widely distributed callosum differences between ASD and TD children. Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD.
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Metagegevens
Titel
Corpus Callosum Morphometrics in Young Children with Autism Spectrum Disorder
Auteurs
Inbal Boger-Megiddo
Dennis W. W. Shaw
Seth D. Friedman
Bobbi F. Sparks
Alan A. Artru
Jay N. Giedd
Geraldine Dawson
Stephen R. Dager
Publicatiedatum
01-08-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0121-2

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