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Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2015

05-06-2015 | Original Paper

Corpus Callosum Area and Brain Volume in Autism Spectrum Disorder: Quantitative Analysis of Structural MRI from the ABIDE Database

Auteurs: R. Kucharsky Hiess, R. Alter, S. Sojoudi, B. A. Ardekani, R. Kuzniecky, H. R. Pardoe

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2015

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Abstract

Reduced corpus callosum area and increased brain volume are two commonly reported findings in autism spectrum disorder (ASD). We investigated these two correlates in ASD and healthy controls using T1-weighted MRI scans from the Autism Brain Imaging Data Exchange (ABIDE). Automated methods were used to segment the corpus callosum and intracranial region. No difference in the corpus callosum area was found between ASD participants and healthy controls (ASD 598.53 ± 109 mm2; control 596.82 ± 102 mm2; p = 0.76). The ASD participants had increased intracranial volume (ASD 1,508,596 ± 170,505 mm3; control 1,482,732 ± 150,873.5 mm3; p = 0.042). No evidence was found for overall ASD differences in the corpus callosum subregions.
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Metagegevens
Titel
Corpus Callosum Area and Brain Volume in Autism Spectrum Disorder: Quantitative Analysis of Structural MRI from the ABIDE Database
Auteurs
R. Kucharsky Hiess
R. Alter
S. Sojoudi
B. A. Ardekani
R. Kuzniecky
H. R. Pardoe
Publicatiedatum
05-06-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2468-8