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Journal of Autism and Developmental Disorders

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28-11-2017 | Original Paper

Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Auteurs: Kaori Maeyama, Kazumi Tomioka, Hiroaki Nagase, Mieko Yoshioka, Yasuko Takagi, Takeshi Kato, Masami Mizobuchi, Shinji Kitayama, Satoshi Takada, Masashi Nagai, Nana Sakakibara, Masahiro Nishiyama, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2018

Abstract

Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

vorige artikel Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels

volgende artikel Do Parents Model Gestures Differently When Children’s Gestures Differ?

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Titel: Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis
Auteurs: Kaori Maeyama
Kazumi Tomioka
Hiroaki Nagase
Mieko Yoshioka
Yasuko Takagi
Takeshi Kato
Masami Mizobuchi
Shinji Kitayama
Satoshi Takada
Masashi Nagai
Nana Sakakibara
Masahiro Nishiyama
Mariko Taniguchi-Ikeda
Ichiro Morioka
Kazumoto Iijima
Noriyuki Nishimura
Publicatiedatum: 28-11-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3412-x

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