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15-01-2021 | Empirical Research

Concurrent and Longitudinal Associations of Sex and Race with Inflammatory Biomarkers during Adolescence

Auteurs: Naoise Mac Giollabhui, Lauren B. Alloy, Dominika Swistun, Christopher L. Coe, Lauren M. Ellman, Daniel P. Moriarity, Allison C. Stumper, Lyn Y. Abramson

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 4/2021

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Abstract

Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 years (SD = 1.56; range: 12.14–21.28)] at three timepoints. Notable results included: general decline in inflammatory biomarkers in older adolescents, lower levels of TNF-α/IL-8 in black adolescents, elevated CRP/IL-6 in females, and especially higher levels of IL-6 in black, female adolescents. Implications are discussed, particularly the potential health implications of elevated IL-6 in black females.
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Metagegevens
Titel
Concurrent and Longitudinal Associations of Sex and Race with Inflammatory Biomarkers during Adolescence
Auteurs
Naoise Mac Giollabhui
Lauren B. Alloy
Dominika Swistun
Christopher L. Coe
Lauren M. Ellman
Daniel P. Moriarity
Allison C. Stumper
Lyn Y. Abramson
Publicatiedatum
15-01-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Youth and Adolescence / Uitgave 4/2021
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI
https://doi.org/10.1007/s10964-020-01369-w