Skip to main content


Swipe om te navigeren naar een ander artikel

19-05-2015 | Uitgave 11/2015

Quality of Life Research 11/2015

Complex coevolution of depression and health-related quality of life in old age

Quality of Life Research > Uitgave 11/2015
André Hajek, Christian Brettschneider, Annette Ernst, Carolin Lange, Birgitt Wiese, Jana Prokein, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Janine Stein, Horst Bickel, Edelgard Mösch, Kathrin Heser, Frank Jessen, Wolfgang Maier, Martin Scherer, Steffi G. Riedel-Heller, Hans-Helmut König
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (doi:10.​1007/​s11136-015-1005-8) contains supplementary material, which is available to authorized users.
For the AgeCoDe Study Group.
Steffi G. Riedel-Heller and Hans-Helmut König have contributed equally to this work.



To investigate the coevolution of depression and health-related quality of life (HRQoL) in old age.


In a representative survey of the German general population aged 75 years and older, the course of HRQoL and depression was observed over 4.5 years (3 waves). HRQoL was assessed by the Visual Analogue Scale (EQ VAS) of the EQ-5D instrument, while the Geriatric Depression Scale was used to measure depression. A panel vector autoregressive model was used to account for the complex coevolution of depression and HRQoL. Unobserved heterogeneity was taken into account by taking the first differences.


We revealed a robust negative association between an initial change in HRQoL and a subsequent change in depression score, with substantial sex differences: In women there was a robust association, while in men the significance of this association depended on the model specification. Surprisingly, in the total sample and in both sexes, no robust association between an initial increase in depression and a subsequent change in HRQoL was found.


Findings indicate that the direction of evolution from HRQoL to depression deserves more attention. Furthermore, treatment of depression in late life should aim at improving HRQoL in which remission of depressive symptoms is necessary but not sufficient.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Extra materiaal
Alleen toegankelijk voor geautoriseerde gebruikers
Over dit artikel

Andere artikelen Uitgave 11/2015

Quality of Life Research 11/2015 Naar de uitgave