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Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2021

03-01-2021 | Original Paper

Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls

Auteurs: Fulya Şimşek, Ümit Işık, Evrim Aktepe, Faruk Kılıç, Fevziye Burcu Şirin, Mustafa Bozkurt

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2021

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Abstract

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1α levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4–12 years were included. Serum levels of VEGF, IGF-1, and HIF-1α were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1α levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1α may play a potential role in the etiopathogenesis of ASD.
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Metagegevens
Titel
Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls
Auteurs
Fulya Şimşek
Ümit Işık
Evrim Aktepe
Faruk Kılıç
Fevziye Burcu Şirin
Mustafa Bozkurt
Publicatiedatum
03-01-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04820-w