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Gepubliceerd in: Child Psychiatry & Human Development 4/2012

01-08-2012 | Original Article

Comparison of Saliva Collection Methods in Children with High-Functioning Autism Spectrum Disorders: Acceptability and Recovery of Cortisol

Auteurs: Susan K. Putnam, Christopher Lopata, Jeffery D. Fox, Marcus L. Thomeer, Jonathan D. Rodgers, Martin A. Volker, Gloria K. Lee, Erik G. Neilans, Jilynn Werth

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 4/2012

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Abstract

This study compared cortisol concentrations yielded using three saliva collection methods (passive drool, salivette, and sorbette) in both in vitro and in vivo conditions, as well as method acceptability for a sample of children (n = 39) with High Functioning Autism Spectrum Disorders. No cortisol concentration differences were observed between passive and sorbette samples obtained in vitro or in vivo. The salivette derived concentration was lower than the other two methods for the in vitro derived comparisons but did not differ from the other methods when collected in vivo. Cross-day comparison for the salivettes was also found to differ significantly, whereas the cross-day comparisons did not differ for the passive method or the sorbette method. Overall, passive drool and sorbettes were found to produce similar and stable readings of cortisol, whereas the salivette yielded unstable and variable concentrations. Ratings suggested that the children generally perceived all methods as acceptable.
Literatuur
1.
go back to reference American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders 4th edition (DSM-IV-TR). American Psychiatric Association, Washington, DCCrossRef American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders 4th edition (DSM-IV-TR). American Psychiatric Association, Washington, DCCrossRef
2.
go back to reference Baron MG, Lipsitt LP, Groden J, Groden G (2006) Introduction. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 3–11 Baron MG, Lipsitt LP, Groden J, Groden G (2006) Introduction. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 3–11
3.
go back to reference Tsai L (2006) Diagnosis and treatment of anxiety disorders in individuals with autism spectrum disorder. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 388–440 Tsai L (2006) Diagnosis and treatment of anxiety disorders in individuals with autism spectrum disorder. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 388–440
4.
go back to reference Weisbrot DM, Gadow KD, DeVincent CJ, Pomeroy J (2005) The presentation of anxiety in children with pervasive developmental disorders. J Child Adol Psychop 15(3):477–496CrossRef Weisbrot DM, Gadow KD, DeVincent CJ, Pomeroy J (2005) The presentation of anxiety in children with pervasive developmental disorders. J Child Adol Psychop 15(3):477–496CrossRef
5.
go back to reference Gadow KD, DeVincent CJ, Pomeroy J, Azizian A (2005) Comparison of DSM-IV symptoms in elementary school-age children with PDD versus clinic and community samples. Autism 9(4):392–415PubMedCrossRef Gadow KD, DeVincent CJ, Pomeroy J, Azizian A (2005) Comparison of DSM-IV symptoms in elementary school-age children with PDD versus clinic and community samples. Autism 9(4):392–415PubMedCrossRef
6.
go back to reference Gillott A, Furniss F, Walter A (2001) Anxiety in high-functioning children with autism. Autism 5(3):277–286PubMedCrossRef Gillott A, Furniss F, Walter A (2001) Anxiety in high-functioning children with autism. Autism 5(3):277–286PubMedCrossRef
7.
go back to reference Lopata C, Volker MA, Putnam SK, Thomeer ML, Nida RE (2008) Effect of social familiarity on salivary cortisol and self-reports of social anxiety and stress in children with high functioning autism spectrum disorders. J Autism Dev Disord 38:1866–1877PubMedCrossRef Lopata C, Volker MA, Putnam SK, Thomeer ML, Nida RE (2008) Effect of social familiarity on salivary cortisol and self-reports of social anxiety and stress in children with high functioning autism spectrum disorders. J Autism Dev Disord 38:1866–1877PubMedCrossRef
8.
go back to reference Morgan K (2006) Is autism a stress disorder? What studies of nonautistic populations can tell us. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 129–182 Morgan K (2006) Is autism a stress disorder? What studies of nonautistic populations can tell us. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 129–182
9.
go back to reference Church C, Alisanski S, Amanullah S (2000) The social, behavioral, and academic experiences of children with Asperger syndrome. Focus Autism Other Dev Disabil 15(1):2–20CrossRef Church C, Alisanski S, Amanullah S (2000) The social, behavioral, and academic experiences of children with Asperger syndrome. Focus Autism Other Dev Disabil 15(1):2–20CrossRef
10.
go back to reference Groden J, Baron MG, Groden G (2006) Assessment and coping strategies. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 15–41 Groden J, Baron MG, Groden G (2006) Assessment and coping strategies. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 15–41
11.
go back to reference Lopata C, Gitman K, Toomey JA, Volker MA, Nida RE, Thomeer ML, McDonald CA (2009) Experimental study examining the effect of social familiarity on behavioral manifestations of stress and anxiety in children with high-functioning autism spectrum disorders. In: Heidenreich P, Pruter I (eds) Handbook of stress: causes, effects, and control. Nova Science, Hauppauge, pp 347–365 Lopata C, Gitman K, Toomey JA, Volker MA, Nida RE, Thomeer ML, McDonald CA (2009) Experimental study examining the effect of social familiarity on behavioral manifestations of stress and anxiety in children with high-functioning autism spectrum disorders. In: Heidenreich P, Pruter I (eds) Handbook of stress: causes, effects, and control. Nova Science, Hauppauge, pp 347–365
12.
go back to reference Romanczyk RG, Gillis JM (2006) Autism and the physiology of stress and anxiety. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 183–204 Romanczyk RG, Gillis JM (2006) Autism and the physiology of stress and anxiety. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 183–204
13.
go back to reference Baron MG, Lipsitt LP, Goodwin MS (2006) Scientific foundations for research and practice. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 42–67 Baron MG, Lipsitt LP, Goodwin MS (2006) Scientific foundations for research and practice. In: Baron MG, Groden J, Groden G, Lipsitt LP (eds) Stress and coping in autism. Oxford University Press, New York, pp 42–67
14.
go back to reference Hill E, Berthoz S, Frith U (2004) Brief report: cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives. J Autism Dev Disord 34(2):229–235PubMedCrossRef Hill E, Berthoz S, Frith U (2004) Brief report: cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives. J Autism Dev Disord 34(2):229–235PubMedCrossRef
15.
go back to reference Evans DW, Canavera K, Kleinpeter FL, Maccubbin E, Taga K (2005) The fears, phobias, and anxieties of children with autism spectrum disorders and down syndrome: comparison with developmentally and chronologically age matched children. Child Psychiatry Hum Dev 36(1):3–26PubMedCrossRef Evans DW, Canavera K, Kleinpeter FL, Maccubbin E, Taga K (2005) The fears, phobias, and anxieties of children with autism spectrum disorders and down syndrome: comparison with developmentally and chronologically age matched children. Child Psychiatry Hum Dev 36(1):3–26PubMedCrossRef
16.
go back to reference Corbett BA, Mendoza S, Abdullah M, Wegelin JA, Levine S (2006) Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology 31:59–68PubMedCrossRef Corbett BA, Mendoza S, Abdullah M, Wegelin JA, Levine S (2006) Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology 31:59–68PubMedCrossRef
17.
go back to reference Klimes-Dougan B, Hastings PD, Granger DA, Usher BA, Zahn-Waxler C (2001) Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variations, and responses to social challenges. Dev Psychopathol 13:695–719PubMedCrossRef Klimes-Dougan B, Hastings PD, Granger DA, Usher BA, Zahn-Waxler C (2001) Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variations, and responses to social challenges. Dev Psychopathol 13:695–719PubMedCrossRef
18.
go back to reference Curin JM, Terzie J, Petkovic ZB, Zekban L, Terzic IM, Susnjara IM (2003) Lower cortisol and higher ACTH levels in individuals with autism. J Autism Dev Disord 33(4):443–447PubMedCrossRef Curin JM, Terzie J, Petkovic ZB, Zekban L, Terzic IM, Susnjara IM (2003) Lower cortisol and higher ACTH levels in individuals with autism. J Autism Dev Disord 33(4):443–447PubMedCrossRef
19.
go back to reference Nir E, Meir D, Zilber N, Knobler H, Hadjez J, Lerner Y (1995) Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. J Autism Dev Disord 25(6):641–654PubMedCrossRef Nir E, Meir D, Zilber N, Knobler H, Hadjez J, Lerner Y (1995) Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. J Autism Dev Disord 25(6):641–654PubMedCrossRef
20.
go back to reference Kirschbaum C, Read GF, Hellhammer D (1992) Assessment of hormones and drugs in saliva in biobehavioral research. Hogrefe and Huber, Seattle Kirschbaum C, Read GF, Hellhammer D (1992) Assessment of hormones and drugs in saliva in biobehavioral research. Hogrefe and Huber, Seattle
21.
go back to reference Jansen LMC, Weid CCG, van der Gaag J, van Engeland H (2003) Differentiation between autism and multiple complex developmental disorders in response to psychosocial stress. Neuropsychopharmacology 28:582–590PubMedCrossRef Jansen LMC, Weid CCG, van der Gaag J, van Engeland H (2003) Differentiation between autism and multiple complex developmental disorders in response to psychosocial stress. Neuropsychopharmacology 28:582–590PubMedCrossRef
22.
go back to reference Strazdins L, Meyerkort S, Brent V, D’Souza RM, Broom DH, Kyd JM (2005) Impact of saliva collection methods on sIgA and cortisol assays and acceptability to participants. J Immunol Methods 307:167–171PubMedCrossRef Strazdins L, Meyerkort S, Brent V, D’Souza RM, Broom DH, Kyd JM (2005) Impact of saliva collection methods on sIgA and cortisol assays and acceptability to participants. J Immunol Methods 307:167–171PubMedCrossRef
23.
go back to reference Granger DA, Kivlighan KT, Fortunato C, Harmon AG, Hibel LC, Schwartz EB, Whembolua GL (2007) Integration of salivary biomarkers into developmental and behaviorally-oriented research: problems and solutions for collecting specimens. Physiol Behav 92(4):583–590PubMedCrossRef Granger DA, Kivlighan KT, Fortunato C, Harmon AG, Hibel LC, Schwartz EB, Whembolua GL (2007) Integration of salivary biomarkers into developmental and behaviorally-oriented research: problems and solutions for collecting specimens. Physiol Behav 92(4):583–590PubMedCrossRef
24.
go back to reference Gröschl M, Rauh M (2006) Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids 71:1097–1100PubMedCrossRef Gröschl M, Rauh M (2006) Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids 71:1097–1100PubMedCrossRef
25.
go back to reference Shirtcliff EA, Granger DA, Schwartz E, Curran MJ (2001) Use of salivary biomarkers in biobehavioral research: cotton-based sample collections can interfere with salivary immunoassay results. Psychoneuroendocrinology 26(2):165–173PubMedCrossRef Shirtcliff EA, Granger DA, Schwartz E, Curran MJ (2001) Use of salivary biomarkers in biobehavioral research: cotton-based sample collections can interfere with salivary immunoassay results. Psychoneuroendocrinology 26(2):165–173PubMedCrossRef
26.
go back to reference Kozaki T, Hashiguchi N, Kaji Y, Yasukouchi A, Tochihara Y (2009) Effects of saliva collection using cotton swab on cortisol enzyme immunoassay. Eur J Appl Physiol 107(6):743–746PubMedCrossRef Kozaki T, Hashiguchi N, Kaji Y, Yasukouchi A, Tochihara Y (2009) Effects of saliva collection using cotton swab on cortisol enzyme immunoassay. Eur J Appl Physiol 107(6):743–746PubMedCrossRef
27.
go back to reference Gallagher P, Leitch MM, Massey AE, McAllister-Williams RH, Young AH (2006) Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method. J Psychopharmacol 20(5):643–649PubMedCrossRef Gallagher P, Leitch MM, Massey AE, McAllister-Williams RH, Young AH (2006) Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method. J Psychopharmacol 20(5):643–649PubMedCrossRef
28.
go back to reference Poll EM, Kreitschmann-Andermahr I, Langejuergen Y, Stanzel S, Gilsbach JM, Yagmur E (2007) Saliva collection method affects predictability of serum cortisol. Int J Clin Chem 382(1–2):15–19CrossRef Poll EM, Kreitschmann-Andermahr I, Langejuergen Y, Stanzel S, Gilsbach JM, Yagmur E (2007) Saliva collection method affects predictability of serum cortisol. Int J Clin Chem 382(1–2):15–19CrossRef
29.
go back to reference Donzella B, Talge NM, Smith TL, Gunnar MR (2008) To spear or not to spear: comparison of saliva collection methods. Dev Psychobiol 50(7):714–717PubMedCrossRef Donzella B, Talge NM, Smith TL, Gunnar MR (2008) To spear or not to spear: comparison of saliva collection methods. Dev Psychobiol 50(7):714–717PubMedCrossRef
30.
go back to reference Kidd S, Midgley P, Lone N, Wallace AM, Nicol M, McIntosh N (2009) A re-investigation of saliva collection procedures that highlights the risk of potential positive interference in cortisol immunoassay. Steroids 74(8):666–668PubMedCrossRef Kidd S, Midgley P, Lone N, Wallace AM, Nicol M, McIntosh N (2009) A re-investigation of saliva collection procedures that highlights the risk of potential positive interference in cortisol immunoassay. Steroids 74(8):666–668PubMedCrossRef
31.
go back to reference Hanrahan K, McCarthy AM, Kleiber C, Lutgendorf S, Tsalikian E (2006) Strategies for salivary cortisol collection and analysis in research with children. Appl Nurs Res 19:95–101PubMedCrossRef Hanrahan K, McCarthy AM, Kleiber C, Lutgendorf S, Tsalikian E (2006) Strategies for salivary cortisol collection and analysis in research with children. Appl Nurs Res 19:95–101PubMedCrossRef
32.
go back to reference Wechsler D (2003) Wechsler intelligence scale for children, 4th edn. The Psychological Corporation, San Antonio Wechsler D (2003) Wechsler intelligence scale for children, 4th edn. The Psychological Corporation, San Antonio
33.
go back to reference Carrow-Woolfolk E (1999) Comprehensive assessment of spoken language. American Guidance Service, Circle Pines Carrow-Woolfolk E (1999) Comprehensive assessment of spoken language. American Guidance Service, Circle Pines
34.
go back to reference Rutter M, LeCouteur A, Lord C (2003) Autism diagnostic interview-revised. Western Psychological Services, Los Angeles Rutter M, LeCouteur A, Lord C (2003) Autism diagnostic interview-revised. Western Psychological Services, Los Angeles
35.
go back to reference Tellegen A, Briggs PF (1967) Old wine in new skins: grouping wechsler subtests into new scales. J Consult Clin Psychol 31:499–506 Tellegen A, Briggs PF (1967) Old wine in new skins: grouping wechsler subtests into new scales. J Consult Clin Psychol 31:499–506
36.
go back to reference Mazefsky CA, Oswald DP (2006) The discriminative ability and diagnostic utility of the ADOS-G, ADI-R, and GARS for children in a clinical setting. Autism 10(6):533–549PubMedCrossRef Mazefsky CA, Oswald DP (2006) The discriminative ability and diagnostic utility of the ADOS-G, ADI-R, and GARS for children in a clinical setting. Autism 10(6):533–549PubMedCrossRef
37.
go back to reference Stevens J (1996) Applied multivariate statistics for the social sciences, 3rd edn. Lawrence Erlbaum, Mahwah Stevens J (1996) Applied multivariate statistics for the social sciences, 3rd edn. Lawrence Erlbaum, Mahwah
38.
go back to reference Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum, Hillsdale Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum, Hillsdale
39.
go back to reference Corbett BA, Mendoza S, Wegelin JA, Carmean V, Levine S (2008) Variable cortisol circadian rhythms in children with autism and anticipatory stress. J Psychiatry Neurosci 33(3):227–234PubMed Corbett BA, Mendoza S, Wegelin JA, Carmean V, Levine S (2008) Variable cortisol circadian rhythms in children with autism and anticipatory stress. J Psychiatry Neurosci 33(3):227–234PubMed
40.
go back to reference Corbett BA, Schupp CW, Levine S, Mendoza S (2009) Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Res 2:39–49PubMedCrossRef Corbett BA, Schupp CW, Levine S, Mendoza S (2009) Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Res 2:39–49PubMedCrossRef
41.
go back to reference Corbett BA, Schupp CW, Simon D, Ryan N, Mendoza S (2010) Elevated cortisol during play is associated with age and social engagement in children with autism. Mol Autism 1(1):3CrossRef Corbett BA, Schupp CW, Simon D, Ryan N, Mendoza S (2010) Elevated cortisol during play is associated with age and social engagement in children with autism. Mol Autism 1(1):3CrossRef
42.
go back to reference Zinke K, Fries E, Kliegel M, Kirschbaum C, Dettenborn L (2010) Children with high-functioning autism show a normal cortisol awakening response (CAR). Psychoneuroendocrinology 35:1578–1582PubMedCrossRef Zinke K, Fries E, Kliegel M, Kirschbaum C, Dettenborn L (2010) Children with high-functioning autism show a normal cortisol awakening response (CAR). Psychoneuroendocrinology 35:1578–1582PubMedCrossRef
43.
go back to reference Viau R, Arsenault-Lapierre G, Fecteau S, Champagne N, Walker CD, Lupien S (2010) Effects of service dogs on salivary cortisol secretion in autistic children. Psychoneuroendocrinology 35(8):1187–1193PubMedCrossRef Viau R, Arsenault-Lapierre G, Fecteau S, Champagne N, Walker CD, Lupien S (2010) Effects of service dogs on salivary cortisol secretion in autistic children. Psychoneuroendocrinology 35(8):1187–1193PubMedCrossRef
Metagegevens
Titel
Comparison of Saliva Collection Methods in Children with High-Functioning Autism Spectrum Disorders: Acceptability and Recovery of Cortisol
Auteurs
Susan K. Putnam
Christopher Lopata
Jeffery D. Fox
Marcus L. Thomeer
Jonathan D. Rodgers
Martin A. Volker
Gloria K. Lee
Erik G. Neilans
Jilynn Werth
Publicatiedatum
01-08-2012
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 4/2012
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-012-0284-3

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