Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment 2/2008

01-06-2008

Comorbidity of Pediatric Obsessive–Compulsive Disorder and Anxiety Disorders: Impact on Symptom Severity and Impairment

Auteurs: Eric A. Storch, Michael J. Larson, Lisa J. Merlo, Mary L. Keeley, Marni L. Jacob, Gary R. Geffken, Tanya K. Murphy, Wayne K. Goodman

Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment | Uitgave 2/2008

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

This study explored the impact of comorbidity on symptom severity and treatment outcome in a sample of 75 pediatric Obsessive–Compulsive Disorder (OCD) patients. Forty received cognitive–behavioral therapy (CBT). Overall, 56% had a comorbid disorder. Results revealed that youth with comorbid disorders (anxiety or otherwise) endorsed significantly more anxiety symptoms than youth with OCD only. Youth with comorbidities instead of or in addition to anxiety exhibited more severe OCD symptoms than youth with OCD alone or an anxiety-only comorbidity. Youth in the comorbidities instead of or in addition to anxiety group had the poorest CBT response relative to the other groups. These results suggest that relative to those with OCD alone or with an anxiety disorder comorbidity, youth with comorbidities instead of or in addition to anxiety have a differing clinical presentation (e.g., more severe symptoms) and worse psychotherapy outcome.
Voetnoten
1
Percentages are over 100% due to several individuals diagnosed with multiple comorbid conditions.
 
Literatuur
go back to reference Achenbach, T. M. (1991). Manual for the child behavior checklist/4-18 and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry. Achenbach, T. M. (1991). Manual for the child behavior checklist/4-18 and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry.
go back to reference Calvocoressi, L., Lewis, B., Harris, M., Trufan, S. J., Goodman, W. K., McDougle, C. J. et al. (1995). Family accommodation in obsessive compulsive disorder. American Journal of Psychiatry, 152, 441–443. PubMed Calvocoressi, L., Lewis, B., Harris, M., Trufan, S. J., Goodman, W. K., McDougle, C. J. et al. (1995). Family accommodation in obsessive compulsive disorder. American Journal of Psychiatry, 152, 441–443. PubMed
go back to reference Calvocoressi, L., Mazure, C., Kasl, S. V., Skolnick, J., Fisk, D., Vegso, S. J. et al. (1999). Family accommodation of obsessive–compulsive symptoms: Instrument development and assessment of family behavior. Journal of Nervous and Mental Disease, 187, 636–642. PubMedCrossRef Calvocoressi, L., Mazure, C., Kasl, S. V., Skolnick, J., Fisk, D., Vegso, S. J. et al. (1999). Family accommodation of obsessive–compulsive symptoms: Instrument development and assessment of family behavior. Journal of Nervous and Mental Disease, 187, 636–642. PubMedCrossRef
go back to reference Carter, A. S., Pollock, R. A., Suvak, M. K., & Pauls, D. L. (2004). Anxiety and major depression comorbidity in a family study of obsessive–compulsive disorder. Depression and Anxiety, 20, 165–174. PubMedCrossRef Carter, A. S., Pollock, R. A., Suvak, M. K., & Pauls, D. L. (2004). Anxiety and major depression comorbidity in a family study of obsessive–compulsive disorder. Depression and Anxiety, 20, 165–174. PubMedCrossRef
go back to reference Geffken, G. R., Storch, E. A., Duke, D., Lewin, A., Monaco, L., & Goodman, W. K. (2006). Hope and coping in family members of patients with obsessive compulsive disorder. Journal of Anxiety Disorders, 20, 614–629. PubMedCrossRef Geffken, G. R., Storch, E. A., Duke, D., Lewin, A., Monaco, L., & Goodman, W. K. (2006). Hope and coping in family members of patients with obsessive compulsive disorder. Journal of Anxiety Disorders, 20, 614–629. PubMedCrossRef
go back to reference Geller, D. A., Biederman, J., Griffin, S., Jones, J., & Lefkowitz, T. R. (1996). Comorbidity of juvenile obsessive–compulsive disorder with disruptive behaviour disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1637–1646. PubMedCrossRef Geller, D. A., Biederman, J., Griffin, S., Jones, J., & Lefkowitz, T. R. (1996). Comorbidity of juvenile obsessive–compulsive disorder with disruptive behaviour disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1637–1646. PubMedCrossRef
go back to reference Geller, D. A., Biederman, J., Stewart, S. E., Mullin, B., Farrel, C., Wagner, K. D. et al. (2003a). Impact of comorbidity on treatment response to paroxetine in pediatric obsessive–compulsive disorder: Is the use of exclusion criteria empirically supported in randomized clinical trials? Journal of Child and Adolescent Psychopharmacology, 13, S19–S29. PubMedCrossRef Geller, D. A., Biederman, J., Stewart, S. E., Mullin, B., Farrel, C., Wagner, K. D. et al. (2003a). Impact of comorbidity on treatment response to paroxetine in pediatric obsessive–compulsive disorder: Is the use of exclusion criteria empirically supported in randomized clinical trials? Journal of Child and Adolescent Psychopharmacology, 13, S19–S29. PubMedCrossRef
go back to reference Geller, D. A., Coffey, B., Faraone, S., Hagermoser, L., Zaman, N. K., Farrell, C. L. et al. (2003b). Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive–compulsive disorder? CNS Spectrums, 8, 259–264. PubMed Geller, D. A., Coffey, B., Faraone, S., Hagermoser, L., Zaman, N. K., Farrell, C. L. et al. (2003b). Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive–compulsive disorder? CNS Spectrums, 8, 259–264. PubMed
go back to reference Geller, D. A., Biederman, J., Faraone, S., Agranat, A., Cradock, K., Hagermoser, L. et al. (2001). Developmental aspects of obsessive compulsive disorder: Findings in children, adolescents, and adults. Journal Nervous Mental Disorders, 189, 471–477. CrossRef Geller, D. A., Biederman, J., Faraone, S., Agranat, A., Cradock, K., Hagermoser, L. et al. (2001). Developmental aspects of obsessive compulsive disorder: Findings in children, adolescents, and adults. Journal Nervous Mental Disorders, 189, 471–477. CrossRef
go back to reference Guy, W. (1976). Assessment manual for psychopharmacology, revised (DHEW Publication ABM 76-366). Washington DC: US Government Printing Office. Guy, W. (1976). Assessment manual for psychopharmacology, revised (DHEW Publication ABM 76-366). Washington DC: US Government Printing Office.
go back to reference Hanna, G. L., Yuwiler, A., & Coates, J. K. (1995). Whole blood serotonin and disruptive behaviors in juvenile obsessive–compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 28–35. PubMed Hanna, G. L., Yuwiler, A., & Coates, J. K. (1995). Whole blood serotonin and disruptive behaviors in juvenile obsessive–compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 28–35. PubMed
go back to reference Kovacs, M. (1992). The children’s depression inventory. Manual. Toronto, Ontario, Canada: Multi-Health Systems, Inc. Kovacs, M. (1992). The children’s depression inventory. Manual. Toronto, Ontario, Canada: Multi-Health Systems, Inc.
go back to reference Ledley, D. R., Pai, A., & Franklin, M. E. (2007). Treating comorbid presentations: Obsessive compulsive disorder, anxiety disorders, and depression. In M. Antony, C. Purdon, & L. J. Summerfeldt (Eds.). Psychological treatment of obsessive–compulsive disorder: Fundamentals and beyond (pp 281–293). Washington, DC.: American Psychological Association. CrossRef Ledley, D. R., Pai, A., & Franklin, M. E. (2007). Treating comorbid presentations: Obsessive compulsive disorder, anxiety disorders, and depression. In M. Antony, C. Purdon, & L. J. Summerfeldt (Eds.). Psychological treatment of obsessive–compulsive disorder: Fundamentals and beyond (pp 281–293). Washington, DC.: American Psychological Association. CrossRef
go back to reference March, J. S., Parker, J. D., Sullivan, K., Stallings, P., & Conners, C. K. (1997). The Multidimensional Anxiety Scale for Children: Factor structure, reliability, and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 554–565. PubMed March, J. S., Parker, J. D., Sullivan, K., Stallings, P., & Conners, C. K. (1997). The Multidimensional Anxiety Scale for Children: Factor structure, reliability, and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 554–565. PubMed
go back to reference March, J. S, Sullivan, K., & Parker, J. D. (1999). Test–retest reliability of the Multidimensional Anxiety Scale for Children. Journal of Anxiety Disorders, 13, 349–358. PubMedCrossRef March, J. S, Sullivan, K., & Parker, J. D. (1999). Test–retest reliability of the Multidimensional Anxiety Scale for Children. Journal of Anxiety Disorders, 13, 349–358. PubMedCrossRef
go back to reference Masi, G., Perugi, G., Toni, C., Millepiedi, S., Mucci, M., Bertini, N.et al. (2004). Obsessive–compulsive bipolar comorbidity: Focus on children and adolescents. Journal of Affective Disorders, 78, 175–183. PubMedCrossRef Masi, G., Perugi, G., Toni, C., Millepiedi, S., Mucci, M., Bertini, N.et al. (2004). Obsessive–compulsive bipolar comorbidity: Focus on children and adolescents. Journal of Affective Disorders, 78, 175–183. PubMedCrossRef
go back to reference Masi, G., Millepiedi, S., Mucci, M., Bertini, N., Pfanner, C., & Arcangeli, F. (2006). Comorbidity of obsessive–compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Comprehensive Psychiatry, 46, 42–47. CrossRef Masi, G., Millepiedi, S., Mucci, M., Bertini, N., Pfanner, C., & Arcangeli, F. (2006). Comorbidity of obsessive–compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Comprehensive Psychiatry, 46, 42–47. CrossRef
go back to reference National Institute of Mental Health (1985). Rating scales and assessment instruments for use in pediatric psychopharmacology research. Psychopharmacology Bulletin, 21, 839–843. National Institute of Mental Health (1985). Rating scales and assessment instruments for use in pediatric psychopharmacology research. Psychopharmacology Bulletin, 21, 839–843.
go back to reference Pediatric Obsessive–Compulsive Disorder Treatment Study Team (2004). Cognitive–behavioral therapy, sertraline, and their combination for children and adolescents with obsessive–compulsive disorder: The Pediatric Obsessive–Compulsive Disorder Treatment Study (POTS) Randomized Controlled Trial. Journal of the American Medical Association, 292, 1969–1976. CrossRef Pediatric Obsessive–Compulsive Disorder Treatment Study Team (2004). Cognitive–behavioral therapy, sertraline, and their combination for children and adolescents with obsessive–compulsive disorder: The Pediatric Obsessive–Compulsive Disorder Treatment Study (POTS) Randomized Controlled Trial. Journal of the American Medical Association, 292, 1969–1976. CrossRef
go back to reference Piacentini, J. C., Bergman, R. L., Keller, M., & McCracken, J. (2003). Functional impairment in children and adolescents with obsessive–compulsive disorder. Journal of Child and Adolescent Psychopharmacology, 13, S61–S69. PubMedCrossRef Piacentini, J. C., Bergman, R. L., Keller, M., & McCracken, J. (2003). Functional impairment in children and adolescents with obsessive–compulsive disorder. Journal of Child and Adolescent Psychopharmacology, 13, S61–S69. PubMedCrossRef
go back to reference Rasmussen, S. A., & Tsuang, M. T. (1986). Clinical characteristics and family history in DSM-III obsessive–compulsive disorder. American Journal of Psychiatry, 143, 317–322. PubMed Rasmussen, S. A., & Tsuang, M. T. (1986). Clinical characteristics and family history in DSM-III obsessive–compulsive disorder. American Journal of Psychiatry, 143, 317–322. PubMed
go back to reference Rasmussen, S. A., & Eisen, J. L. (1988). Clinical and epidemiologic findings of significance to neuropharmacologic trials in OCD. Psychopharmacology Bulletin, 24, 466–470. PubMed Rasmussen, S. A., & Eisen, J. L. (1988). Clinical and epidemiologic findings of significance to neuropharmacologic trials in OCD. Psychopharmacology Bulletin, 24, 466–470. PubMed
go back to reference Riddle, M. A., Hardin, M. T., King, R., Scahill L., & Woolston, J. L. (1990). Fluoxetine treatment of children and adolescents with Tourette’s and obsessive compulsive disorders: Preliminary clinical experience. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 45–48. CrossRef Riddle, M. A., Hardin, M. T., King, R., Scahill L., & Woolston, J. L. (1990). Fluoxetine treatment of children and adolescents with Tourette’s and obsessive compulsive disorders: Preliminary clinical experience. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 45–48. CrossRef
go back to reference Rufer, M., Grothusen, A., Mass, R., Peter, J., & Hand, I. (2005). Temporal stability of symptom dimensions in adult patients with obsessive–compulsive disorder. Journal of Affective Disorders, 88, 99–102. PubMedCrossRef Rufer, M., Grothusen, A., Mass, R., Peter, J., & Hand, I. (2005). Temporal stability of symptom dimensions in adult patients with obsessive–compulsive disorder. Journal of Affective Disorders, 88, 99–102. PubMedCrossRef
go back to reference Scahill, L., Riddle, M. A., McSwiggin-Hardin, M., Ort, S. I., King, R. A., Goodman, W. K. et al. (1997). Children’s Yale–Brown Obsessive Compulsive Scale: Reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 844–852. PubMedCrossRef Scahill, L., Riddle, M. A., McSwiggin-Hardin, M., Ort, S. I., King, R. A., Goodman, W. K. et al. (1997). Children’s Yale–Brown Obsessive Compulsive Scale: Reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 844–852. PubMedCrossRef
go back to reference Silverman, W. K., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM-IV: Child and parent versions. San Antonio, TX: Psychological Corporation. Silverman, W. K., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM-IV: Child and parent versions. San Antonio, TX: Psychological Corporation.
go back to reference Silverman, W. K., Saavedra, L. M., & Pina, A. A. (2001). Test–retest reliability of anxiety symptoms and diagnoses with anxiety disorders interview schedule for DSM-IV: Child and parent versions. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 937–944. PubMedCrossRef Silverman, W. K., Saavedra, L. M., & Pina, A. A. (2001). Test–retest reliability of anxiety symptoms and diagnoses with anxiety disorders interview schedule for DSM-IV: Child and parent versions. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 937–944. PubMedCrossRef
go back to reference Storch, E. A., Murphy, T. K., Geffken, G. R., Soto, O., Sajid, M., Allen, P. et al. (2004). Psychometric evaluation of the Children’s Yale–Brown Obsessive Compulsive Scale. Psychiatry Research, 129, 91–98. PubMedCrossRef Storch, E. A., Murphy, T. K., Geffken, G. R., Soto, O., Sajid, M., Allen, P. et al. (2004). Psychometric evaluation of the Children’s Yale–Brown Obsessive Compulsive Scale. Psychiatry Research, 129, 91–98. PubMedCrossRef
go back to reference Storch, E. A., Geffken, G. R., Merlo, L. J., Mann, G., Duke, D., Munson, M. et al. (2007a). Cognitive–behavioral therapy for pediatric obsessive–compulsive disorder: Comparison of intensive and weekly approaches. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 469–478. PubMedCrossRef Storch, E. A., Geffken, G. R., Merlo, L. J., Mann, G., Duke, D., Munson, M. et al. (2007a). Cognitive–behavioral therapy for pediatric obsessive–compulsive disorder: Comparison of intensive and weekly approaches. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 469–478. PubMedCrossRef
go back to reference Storch, E. A., Merlo, L. J., Larson, M. J., Fernandez, M., Jacob, M. L., Geffken, G. R. et al. (2007b). Family accommodation in pediatric obsessive–compulsive disorder. Journal of Clinical Child and Adolescent Psychology, 36, 207–216. PubMedCrossRef Storch, E. A., Merlo, L. J., Larson, M. J., Fernandez, M., Jacob, M. L., Geffken, G. R. et al. (2007b). Family accommodation in pediatric obsessive–compulsive disorder. Journal of Clinical Child and Adolescent Psychology, 36, 207–216. PubMedCrossRef
go back to reference Sukhodolsky, D. G., Do Rosario-Campos, M. C., Scahill, L., Katsovich, L., Pauls, D. L., Peterson, B. S. et al. (2005). Adaptive, emotional, and family functioning of children with obsessive–compulsive disorder and comorbid attention deficit hyperactivity disorder. American Journal of Psychiatry, 162, 1125–1132. PubMedCrossRef Sukhodolsky, D. G., Do Rosario-Campos, M. C., Scahill, L., Katsovich, L., Pauls, D. L., Peterson, B. S. et al. (2005). Adaptive, emotional, and family functioning of children with obsessive–compulsive disorder and comorbid attention deficit hyperactivity disorder. American Journal of Psychiatry, 162, 1125–1132. PubMedCrossRef
go back to reference Swedo, S. E., Rapoport, J. L., Leonard, H., Lenane, M., & Cheslow, D. (1989). Obsessive–compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases. Archives of General Psychiatry, 46, 335–341. PubMed Swedo, S. E., Rapoport, J. L., Leonard, H., Lenane, M., & Cheslow, D. (1989). Obsessive–compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases. Archives of General Psychiatry, 46, 335–341. PubMed
go back to reference Termine, C., Balottin, U., Rossi, G., Maisano, F., Salini, S., Di Nardo, R. et al. (2006). Psychopathology in children and adolescents with Tourette’s syndrome: A controlled study. Brain and Development, 28, 69–75. PubMedCrossRef Termine, C., Balottin, U., Rossi, G., Maisano, F., Salini, S., Di Nardo, R. et al. (2006). Psychopathology in children and adolescents with Tourette’s syndrome: A controlled study. Brain and Development, 28, 69–75. PubMedCrossRef
go back to reference Tükel, R., Polat, A., Özdemir, Ö., Aksüt, D., & Türksoy, N. (2002) Comorbid conditions in obsessive–compulsive disorder. Comprehensive Psychiatry, 43, 204–209. PubMedCrossRef Tükel, R., Polat, A., Özdemir, Ö., Aksüt, D., & Türksoy, N. (2002) Comorbid conditions in obsessive–compulsive disorder. Comprehensive Psychiatry, 43, 204–209. PubMedCrossRef
go back to reference Weissman, M. M., Bland, R. C., Canino, G. J., Greenwald, S., Hwu, H. G., Lee, C. K. et al. (1994). The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. Journal of Clinical Psychiatry, 55, 5–10. PubMed Weissman, M. M., Bland, R. C., Canino, G. J., Greenwald, S., Hwu, H. G., Lee, C. K. et al. (1994). The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. Journal of Clinical Psychiatry, 55, 5–10. PubMed
go back to reference Wood, J. J., Piacentini, J. C., Bergman, R. L., McCracken, J., & Barrios, V. (2002). Concurrent validity of the anxiety disorders section of the Anxiety Disorders Interview Schedule for DSM-IV: Child and parent versions. Journal of Clinical Child and Adolescent Psychology, 31, 335–342. PubMedCrossRef Wood, J. J., Piacentini, J. C., Bergman, R. L., McCracken, J., & Barrios, V. (2002). Concurrent validity of the anxiety disorders section of the Anxiety Disorders Interview Schedule for DSM-IV: Child and parent versions. Journal of Clinical Child and Adolescent Psychology, 31, 335–342. PubMedCrossRef
Metagegevens
Titel
Comorbidity of Pediatric Obsessive–Compulsive Disorder and Anxiety Disorders: Impact on Symptom Severity and Impairment
Auteurs
Eric A. Storch
Michael J. Larson
Lisa J. Merlo
Mary L. Keeley
Marni L. Jacob
Gary R. Geffken
Tanya K. Murphy
Wayne K. Goodman
Publicatiedatum
01-06-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Psychopathology and Behavioral Assessment / Uitgave 2/2008
Print ISSN: 0882-2689
Elektronisch ISSN: 1573-3505
DOI
https://doi.org/10.1007/s10862-007-9057-x