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29-01-2015 | Original Article

Cognitive Flexibility and Social Responsiveness in Children and Adolescents with Tourette Syndrome

Auteurs: Ayşegül Selcen Güler, Meral Berkem, Yanki Yazgan, Sibel Kalaça

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 6/2015

Abstract

This study examined cognitive flexibility and social responsiveness in children and adolescents with Tourette Syndrome (TS). Thirty one subjects with TS were compared to 32 age-matched healthy controls. Assessments included semi-structured interviews to assess psychopathology, parent-rated Social Responsiveness Scale (SRS) and a brief neuropsychological battery selected as measures of cognitive flexibility. Completion time for both Trail Making Tests (TMT-A and TMT-B) were significantly longer for TS group than controls, however the difference in perseverative errors on Wisconsin Card Sorting Test (WCST) was not significant. SRS total score was significantly higher in the TS group compared to controls, indicating greater impairment in social responsiveness. Group difference for TMTs and SRS failed to reach significance after controlling for co-occurring conditions. Clinicians might consider social impairment in the evaluation plan of children and adolescents with Tourette syndrome

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Khalifa N, von Knorring AL (2003) Prevalence of tic disorders and Tourette syndrome in a Swedish school population. Dev Med Child Neurol 45:315–319CrossRefPubMed

Stefanoff P, Wolanczyk T, Gawrys A, Swirszcz K, Stefanoff E, Kaminska A, Lojewska-Bajbus M, Mazurek B, Majewska-Stefaniak A, Mikulska J, Brynska A (2008) Prevalence of tic disorders among schoolchildren in Warsaw, Poland. Eur Child Adolesc Psychiatry 17:171–178CrossRefPubMed

Hornsey H, Banerjee S, Zeitlin H, Robertson M (2001) The prevalence of Tourette syndrome in 13–14-year-olds in mainstream schools. J Child Psychol Psychiatry 42:1035–1039CrossRefPubMed

Scahill L, Williams S, Schwab-Stone M, Applegate JO, Leckman JF (2006) Tic disorders and disruptive behavior in a community sample. Adv Neurol 99:184–190PubMed

Scahill L (2009) Prevalence of diagnosed tourette syndrome in persons aged 6–17 years-United States, 2007. MMMR Weekly 58(21):581–585

Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF (2006) Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Arch Pediatr Adolesc Med 160(1):65–69PubMedCentralCrossRefPubMed

Storch EA, Lack CW, Simons LE, Goodman WK, Murphy TK, Geffken GR (2007) A measure of functional impairment in youth with Tourette’s syndrome. J Pediatr Psychol 32:950–959CrossRefPubMed

Storch EA, Merlo LJ, Lack C, Milsom VA, Geffken GR, Goodman WK, Murphy TK (2007) Quality of life in youth with Tourette’s syndrome and chronic tic disorder. J Clin Child Adolesc Psychol 36:217–227CrossRefPubMed

Eddy CM, Rizzo R, Gulisano M, Agodi A, Barchitta M, Cali P, Robertson MM, Cavanna AE (2011) Quality of life in young people with Tourette syndrome: a controlled study. J Neurol 258:291–301CrossRefPubMed

10.

Specht MW, Woods DW, Piacentini J, Scahill L, Wilhelm S, Peterson AL, Chang S, Kepley H, Deckersbach T, Flessner C, Buzzella BA, McGuire JF, Levi-Pearl S, Walkup JT (2011) Clinical characteristics of children and adolescents with a primary tic disorder. J Dev Phys Disabil 23:15–31PubMedCentralCrossRefPubMed

11.

Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P (2000) An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol 42:436–447CrossRefPubMed

12.

Burd L, Freeman RD, Klug MG, Kerbeshian J (2005) Tourette syndrome and learning disabilities. BMC Pediatr 5:34PubMedCentralCrossRefPubMed

13.

Scahill L, Sukhodolsky DG, Williams SK, Leckman JF (2005) Public health significance of tic disorders in children and adolescents. Adv Neurol 96:240–248PubMed

14.

Sukhodolsky DG, Scahill L, Zhang H, Peterson BS, King RA, Lombroso PJ, Katsovich L, Findley D, Leckman JF (2003) Disruptive behavior in children with Tourette’s syndrome: association with ADHD comorbidity, tic severity and functional impairment. J Am Acad Child Adolesc Psychiatry 42(1):98–105CrossRefPubMed

15.

Watkins LH, Sahakian BJ, Robertson MM, Veale DM, Rogers RD, Pickard KM, Aitken MR, Robbins TW (2005) Executive function in Tourette’s syndrome and obsessive–compulsive disorder. Psychol Med 35:571–582CrossRefPubMed

16.

Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006) Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry 163:1282–1284CrossRefPubMed

17.

Harris EL, Schuerholz LJ, Singer HS, Reader MJ, Brown JE, Cox C, Mohr J, Chase GA, Denckla MB (1995) Executive function in children with Tourette syndrome and/or attention deficit hyperactivity disorder. J Int Neuropsychol Soc 1(6):511–516CrossRefPubMed

18.

Ayaz AB, Ayaz M, Yazgan Y (2013) Alterations in social reciprocity in attention-deficit hyperactivity disorder. Turk Psikiyatri Derg 24(2):101–110PubMed

19.

Carter AS, O’Donnell DA, Schultz RT, Scahill L, Leckman JF, Pauls DL (2000) Social and emotional adjustment in children affected with Gilles de la Tourette’s syndrome: associations with ADHD and family functioning. J Child Psychol Psyc 41:215–223CrossRef

20.

Zinner SH, Conelea CA, Glew GM, Woods DW, Budman CL (2012) Peer victimization in youth with Tourette syndrome and other chronic tic disorders. Child Psychiatry Hum Dev 43:124–136CrossRefPubMed

21.

Storch EA, Murphy TK, Chase RM, Keeley M, Goodman WK, Murray M, Geffken GR (2007) Peer victimization in youth with Tourette’s syndrome and chronic tic disorder: relations with tic severity and internalizing symptoms. J Psychopathol Behav 29:211–219CrossRef

22.

Ozonoff S, Strayer DL, McMahon WM, Filloux F (1998) Inhibitory deficits in Tourette syndrome: a function of comorbidity and symptom severity. J Child Psychol Psychiatry 39:1109–1118CrossRefPubMed

23.

Baron-Cohen S, Scahill VL, Izaguirre J, Hornsey H, Robertson MM (1999) The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study. Psychol Med 29:1151–1159CrossRefPubMed

24.

Kadesjo B, Gillberg C (2001) The comorbidity of ADHD in the general population of Sweedish school-age children. J Child Psychol Psychiatry 42(4):487–492CrossRefPubMed

25.

Tabori-Kraft J, Dalsgaard S, Obel C, Thomsen PH, Henriksen TB, Scahill L (2012) Prevalence and clinical correlates of tic disorders in a community sample of school-age children. Eur Child Adolesc Psychiatry 21(1):5–13CrossRef

26.

Gökçen E, Petrides KV, Hudry K, Frederickson N, Smillie LD (2014) Sub-threshold autism traits: the role of trait emotional intelligence and cognitive flexibility. Br J Psychol 105(2):187–199PubMedCentralCrossRefPubMed

27.

Murphy T, Eddy CM (2013) Neuropsycological assessment in tourette syndrome. In: Martino D, Leckman J (eds) Tourette Syndrome. Oxford University Press, New York, pp 439–467CrossRef

28.

Baron-Cohen S, Jolliffe T, Mortimore C, Robertson MM (1997) Another advanced test of theory of mind: evidence from very high functioning adults with autism or Asperger’s syndrome. J Child Psychol Psychiatry 387:813–822CrossRef

29.

Channon S, Sinclair E, Waller D, Healey L, Robertson MM (2004) Social cognition in Tourette’s syndrome and impaired inhibitory functioning. J Autism Dev Disord 34(6):669–677CrossRefPubMed

30.

Eddy CM, Mitchell IJ, Beck SR, Cavanna AE, Rickards H (2010) Altered attribution of intention in Tourette syndrome. J Neuropsychiatry Clin Neurosci 22:348–351CrossRefPubMed

31.

Eddy CM, Mitchell IJ, Beck SR, Cavanna AE, Rickards H (2011) Social reasoning in Tourette syndrome. Cogn Neuropsychiatry 16(4):326–347CrossRefPubMed

32.

Constantino JN, Todd RD (2003) Autistic traits in the general population: a twin study. Arch Gen Psychiatry 60:524–530CrossRefPubMed

33.

Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368:210–215CrossRefPubMed

34.

Constantino JN, Lajonchere C, Lutz M, Gray T, Abbacchi A, McKenna K, Singh D, Todd RD (2006) Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry 163:294–296CrossRefPubMed

35.

Pine DS, Guyer AE, Goldwin M, Towbin KA, Leibenluft E (2008) Autism spectrum scale scores in pediatric mood and anxiety disorders. J Am Acad Child Adolesc Psychiatry 47:6CrossRef

36.

Reiersen AM, Constantino JN, Volk HE, Todd RD (2007) Autistic traits in a population-based ADHD twin sample. J Child Psychol Psychiatry 48(5):464–472CrossRefPubMed

37.

Reiersen AM, Constantino JN, Grimmer M, Martin NG, Todd RD (2008) Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Res Human Genet 11(6):579–585CrossRef

38.

Verte S, Geurts HM, Roeyers H, Oosterlaan J, Sergeant JA (2005) Executive functioning in children with autism and Tourette syndrome. Dev Psychopathol 17:415–445CrossRefPubMed

39.

Geurts HM, Verte S, Oosterlaan J, Roeyers H, Sergeant JA (2004) How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J Child Psychol Psychiatry 45:836–854CrossRefPubMed

40.

Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf L, Brotman MA, Rich BA, Pine DS, Leibenluft E (2007) Cognitive flexibility in phenotypes of pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 46(3):341–355CrossRefPubMed

41.

Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD (2007) Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry 164(2):335–338PubMedCentralCrossRefPubMed

42.

Eddy CM, Rizzo R, Cavanna AE (2009) Neuropsychological aspects of Tourette syndrome: a review. J Psychosom Res 67:503–513CrossRefPubMed

43.

Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathologies. J Child Psychol Psychiatry Annu Res Rev 37:51–87CrossRef

44.

Como PG (2001) Neuropsychological function in Tourette syndrome. Adv Neurol 85:103–111PubMed

45.

Brand B, Geenen R, Oudenhoven M, Lindenborn B, van der Ree A, Cohen-Kettenis P, Buitelaar JK (2002) Brief Report: cognitive functioning in children with Tourette’s syndrome with and without comorbid ADHD. Soc Pediatr Psychol 27(2):203–208CrossRef

46.

McGuire JF, Hanks C, Lewin AB, Storch EA, Murphy TK (2013) Social deficits in children with chronic tic disorders: phenomenology, clinical correlates and quality of life. Compr Psychiatry 54:1023–1031CrossRefPubMed

47.

Clark L, Cools R, Robbins TW (2004) The neuropsychology of ventral prefrontal cortex:decision-making and reversal learning. Brain Cogn 55:41–53CrossRefPubMed

48.

Baron-Cohen S (2008) Autism- in 100 words. Br J Psychiatry 193:321CrossRef

49.

Hill E (2004) Evaluating the theory of executive dysfunction in autism. Dev Rev 24:189–233CrossRef

50.

Yoshida W, Dziobek I, Kliemann D, Heekeren HR, Friston KJ, Dolan RJ (2010) Cooperation and heterogeneity of the autistic mind. J Neurosci 30(26):8815–8818PubMedCentralCrossRefPubMed

51.

Ashby FG, Isen AM, Turken AU (1999) A neuropsychological theory of positive affect and its influence on cognition. Psychol Rev 106(3):529–550CrossRefPubMed

52.

Bull R, Phillips LH, Conway CA (2008) The role of control functions in mentalizing: dual-task studies of theory of mind and executive function. Cognition 107(2):663–672CrossRefPubMed

53.

Bornstein RA (1991) Neuropsychological correlates of obsessive characteristics in tourette syndrome. J Neuropsychiatry Clin Neurosci 3:157–162CrossRefPubMed

54.

Bornstein RA, Yang V (1991) Neuropsychological performance in medicated and unmedicated patients with Tourette’s disorder. Am J Psychiatry 148:468–471CrossRefPubMed

55.

Ozonoff S, Jensen J (1999) Brief report: specific executive function profiles in three neurodevelopmental disorders. J Autism Dev Disord 29(2):171–177CrossRefPubMed

56.

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children—present and lifetime version (KSADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988CrossRefPubMed

57.

Gökler B, Ünal F, Pehlivantürk B, Kültür EÇ, Akdemir D, Taner Y (2004) Okul Çağı Çocukları İçin Duygulanım Bozuklukları ve Şizofreni Görüşme Çizelgesi-Şimdi ve Yaşam Boyu Şekli-Türkçe Uyarlamasının Geçerlik ve Güvenirliği. Çocuk ve Gençlik Ruh Sağlığı Dergisi 11(3):109–116

58.

Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28:566–573CrossRefPubMed

59.

Storch EA, Murphy TK, Geffken GR, Sajid M, Allen P, Roberti JW, Goodman WK (2005) Reliability and validity of the Yale Global Tic Severity Scale. Psychol Assess 17(4):486–491CrossRefPubMed

60.

Zaimoğlu S, Rodopman Arman A, Sabuncuoğlu O (1995) Validation Study of Yale Global Tic Severity Scale. Poster presentation in the 5th National Child and Adolescent Psychiatry Congress, Ankara, Turkey

61.

Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, Cicchetti D, Leckman JF (1997) Children’s Yale-Brown Obsessive-Compulsive Scales: reliability and validity. J Am Acad Child Adolesc Psychiatry 36(6):844–852CrossRefPubMed

62.

Yucelen GA, Rodopman-Arman A, Topcuoglu V, Yazgan MY, Fisek G (2006) Interrater reliability and clinical efficacy of Children’s Yale-Brown Obsessive-Compulsive Scale in an outpatient setting. Compr Psychiatry 47:48–53CrossRefPubMed

63.

Guy W (1976) Clinical global impressions: ECDEU assessment manual for pharmacology (revised edition, pp. 218–222), Rockville, MD: National Institute of Mental Health, Department of Health, Education and Welfare Publication (ADM)

64.

Constantino JN (2002) The social responsiveness scale. Western Psychological Services, Los Angeles

65.

Ünal S, Güler AS, Dedeoğlu C, Taşkın B, Yazgan Y (2009) Social Responsiveness in a clinical sample of ADHD: Comparison with a community control group. Poster presentation in the 19th National Child and Adolescent Psychiatry Congress, Antakya, Turkey

66.

Constantino JN, Todd RD (2005) Intergenerational transmission of subtreshold autistic traits in the general population. Biol Psychiatry 57:655–660CrossRefPubMed

67.

Savasir I, Sahin N (1995) Wechsler Çocuklar İçin Zeka Ölçeği (WISC-R). Turkish Psychological Association, Ankara

68.

Berg EA (1948) A simple objective test for measuring flexibility in thinking. J Gen Psychol 39:15–22CrossRefPubMed

69.

Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G (1993) Wisconsin card sorting test manual: revised and expanded. Psychological Assessment Resources, Odessa, FL

70.

Lezak MD (1995) Neuropsychological assessment. Oxford University Press, New York

71.

Andres S, Boget T, Lazaro L, Penades R, Morer A, Salamero M, Castro-Fornieles J (2007) Neuropsychological performance in children and adolescents with obsessive-compulsive disorder and influence of clinical variables. Biol Psychiatry 61:946–951CrossRefPubMed

72.

Reitan RM, Wolfson D (1992) Neuropsychological evaluation of older children. Neuropsychology Press, Tucson, AZ

73.

Arbuthnott K, Frank J (2000) Trail Making Test, Part B as a measure of executive control: validation using a set-switching paradigm. J Clin Exp Neuropsychol 22:518–528CrossRefPubMed

74.

Kortte KB, Horner MD, Windham WK (2002) The trail making test, part B: cognitive flexibility or ability to maintain set? Appl Neuropsychol 9(2):106–109CrossRefPubMed

75.

Dennis M, Francis DJ, Cirino PT, Schachar R, Barnes MA, Fletcher JM (2009) Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. J Int Neuropsychol Soc 15(3):331–343PubMedCentralCrossRefPubMed

76.

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Earlbaum Associates, Hillsdale, NJ

77.

Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, Pine DS, Leibenluft E (2004) Neuropsychological performance in pediatric bipolar disorder. Biol Psychiatry 55(1):32–39CrossRefPubMed

78.

Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL (1997) Symptoms of obsessive-compulsive disorder. Am J Psychiatry 154(7):911–917CrossRefPubMed

79.

Morer A, Vinas O, Lazaro L, Calvo R, Andres S, Bosch J, Gastó C, Massana J, Castro J (2006) Subtyping obsessive-compulsive disorder: clinical and immunological findings in child and adult onset. J Psychiatr Res 40(3):207–213CrossRefPubMed

80.

Coffey B, Frazier J, Chen S (1992) Comorbidity, Tourette syndrome and anxiety disorders. Adv Neurol 58:95–104PubMed

81.

Wodrich DL, Benjamin E, Lachar D (1997) Tourette’s syndrome and psychopathology in a child psychiatry setting. J Am Acad Child Adolesc Psychiatry 36:1618–1624PubMed

82.

Bloch MH, Leckman JF (2007) Tic disorders. In: Martin A, Volkmar FR (eds) Lewis’s child and adolescent psychiatry: a comprehensive textbook, 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 569–583

83.

Sukhodolsky DG, Landeros-Weisenberger A, Scahill L, Leckman JF, Schultz R (2010) Neuropsychological functioning in children with Tourette syndrome wth and without attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49(11):1155–1164PubMedCentralPubMed

84.

Constantino JN, Gruber CP (2005) Social Responsiveness Scale (SRS). Western Psychological Services

85.

Towbin KE, Pradella A, Gorrindo T, Pine D, Leibenluft E (2005) Autism spectrum traits in children with mood and anxiety disorders. J Child Adolesc Psychopharmacol 15(3):452–464CrossRefPubMed

86.

Nathaniel-James D, Fletcher P, Frith CD (1997) The functional anatomy of verbal initiation and suppression using the Hayling Test. Neuropsychologia 35:559–566CrossRefPubMed

87.

Cirino PT, Chapieski ML, Massman PJ (2000) Card sorting performance and ADHD symptomatology in children and adolescents with Tourette Syndrome. J Clin Exp Neuropsychol 22(2):345–356CrossRef

88.

Khalifa N, Von Knorring AL (2006) Psychopathology in a Swedish population of school children with tic disorders. J Am Acad Child Adolesc Psychiatry 45:1345–1353CrossRef

Titel: Cognitive Flexibility and Social Responsiveness in Children and Adolescents with Tourette Syndrome
Auteurs: Ayşegül Selcen Güler
Meral Berkem
Yanki Yazgan
Sibel Kalaça
Publicatiedatum: 29-01-2015
Uitgeverij: Springer US
Gepubliceerd in: Child Psychiatry & Human Development / Uitgave 6/2015
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI: https://doi.org/10.1007/s10578-015-0533-3

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