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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2007

01-02-2007 | Original Paper

Cognitive and Verbal Abilities of 24- to 36-month-old Siblings of Children with Autism

Auteurs: Nurit Yirmiya, Ifat Gamliel, Michal Shaked, Marian Sigman

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2007

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Abstract

The cognitive and language skills of 30 siblings of children with autism (SIBS-A) and 30 siblings of typically developing children (SIBS-TD) were compared. Non-significant group differences emerged for cognition at both ages. At 24 months, significantly more SIBS-A demonstrated language scores one or two standard deviations below the mean compared to SIBS-TD. At 36 months, the groups differed significantly in receptive language, and more SIBS-A displayed receptive and expressive difficulties compared to SIBS-TD. Six SIBS-A (including one diagnosed with autism) revealed language scores more than two standard deviations below the mean at both ages, a pattern not seen in the SIBS-TD. Results are discussed in reference to language difficulties in autism spectrum disorders and the genetic liability for autism.
Literatuur
go back to reference Alarcon, M., Cantor, R. M., Liu, J., Gilliam, T. C., & Geschwind, D. H. (2002). The autism genetic resource exchange consortium. Evidence for a language quantitative trait locus on chromosome 7q in multiplex families. American Journal of Human Genetics, 70, 60–71. PubMedCrossRef Alarcon, M., Cantor, R. M., Liu, J., Gilliam, T. C., & Geschwind, D. H. (2002). The autism genetic resource exchange consortium. Evidence for a language quantitative trait locus on chromosome 7q in multiplex families. American Journal of Human Genetics, 70, 60–71. PubMedCrossRef
go back to reference American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th edn). Washington, DC: Author. American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th edn). Washington, DC: Author.
go back to reference Ashley-Koch, A., Wolpert, C. M., Menold, M. M., Zaeem, L., Basu, S., Donnelly, S. L., Ravan, S. A., Powell, C. M., Qumsiyeh, M. B., Aylsworth, A. S., Vance, J. M., Gilbert, J. R., Wright, H. H., Abramson, R. K., Delong, G. R., Cuccaru, M. L., & Pericak-Vance, M. A. J. (1999). Genetic studies of autistic disorder. Genomics, 61, 227–236. PubMedCrossRef Ashley-Koch, A., Wolpert, C. M., Menold, M. M., Zaeem, L., Basu, S., Donnelly, S. L., Ravan, S. A., Powell, C. M., Qumsiyeh, M. B., Aylsworth, A. S., Vance, J. M., Gilbert, J. R., Wright, H. H., Abramson, R. K., Delong, G. R., Cuccaru, M. L., & Pericak-Vance, M. A. J. (1999). Genetic studies of autistic disorder. Genomics, 61, 227–236. PubMedCrossRef
go back to reference August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. British Journal of Psychiatry, 138, 416–422. PubMedCrossRef August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. British Journal of Psychiatry, 138, 416–422. PubMedCrossRef
go back to reference Baron-Cohen, S., Allen, J., & Gillberg, C. (1992). Can autism be detected at 18 months? The needle, the haystack and the CHAT. British Journal of Psychiatry, 161, 839–843. PubMedCrossRef Baron-Cohen, S., Allen, J., & Gillberg, C. (1992). Can autism be detected at 18 months? The needle, the haystack and the CHAT. British Journal of Psychiatry, 161, 839–843. PubMedCrossRef
go back to reference Barrett, S., Beck, J., Bernier, R., Bisson, E., Braun, T., Casavant, T., Childress, D., Folstein, S., Garcia, M., Gardiner, M., Gilman, S., Haines, J., Hopkins, K., Landa, R., Meyer, N., Mullane, J., Nishimura, D., Palmer, P., Piven, J., Purdy, J., Santangelo, J., Searby, C., Sheffield, V., Singleton, J., Slager, S., Struchen, T., Svenson, S., Vieland, V., Wang, K., & Winklosky, B. (1999). An autosomal genomic screen for autism. American Journal of Medical Genetics, 88, 609–615. PubMedCrossRef Barrett, S., Beck, J., Bernier, R., Bisson, E., Braun, T., Casavant, T., Childress, D., Folstein, S., Garcia, M., Gardiner, M., Gilman, S., Haines, J., Hopkins, K., Landa, R., Meyer, N., Mullane, J., Nishimura, D., Palmer, P., Piven, J., Purdy, J., Santangelo, J., Searby, C., Sheffield, V., Singleton, J., Slager, S., Struchen, T., Svenson, S., Vieland, V., Wang, K., & Winklosky, B. (1999). An autosomal genomic screen for autism. American Journal of Medical Genetics, 88, 609–615. PubMedCrossRef
go back to reference Bartlett, C. W., Flax, J. F., Logue, M. W., Smith, B. J., Vieland, V. J., Tallal, P. et al., (2004). Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Human Heredity, 57, 10–20. PubMedCrossRef Bartlett, C. W., Flax, J. F., Logue, M. W., Smith, B. J., Vieland, V. J., Tallal, P. et al., (2004). Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Human Heredity, 57, 10–20. PubMedCrossRef
go back to reference Bates, J. E., Freeland, C. A., & Lounsbury, M. L. (1979). Measurement of infant difficultness. Child Development, 50, 794–803. PubMedCrossRef Bates, J. E., Freeland, C. A., & Lounsbury, M. L. (1979). Measurement of infant difficultness. Child Development, 50, 794–803. PubMedCrossRef
go back to reference Bayley, N. (1993). Bayley scales of infant development (2nd ed.). San Antonio, TX: Psychological Corporation. Bayley, N. (1993). Bayley scales of infant development (2nd ed.). San Antonio, TX: Psychological Corporation.
go back to reference Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999). Autism screening questionnaire: Diagnostic validity. British Journal of Psychiatry, 175, 444–451. PubMed Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999). Autism screening questionnaire: Diagnostic validity. British Journal of Psychiatry, 175, 444–451. PubMed
go back to reference Bishop, D. V. M. (2003). Genetic and environmental risks for specific impairment in children. International Journal of Pediatric Otorhinolaryngology, 6751, S143–S157. CrossRef Bishop, D. V. M. (2003). Genetic and environmental risks for specific impairment in children. International Journal of Pediatric Otorhinolaryngology, 6751, S143–S157. CrossRef
go back to reference Bishop, D. V. M., Price, T. S., Dale, P. S., & Plomin, R. (2003). Outcomes of early language delay: II. Etiology of transient and persistent language difficulties. Journal of Speech Language and Hearing Research, 46, 561–575. CrossRef Bishop, D. V. M., Price, T. S., Dale, P. S., & Plomin, R. (2003). Outcomes of early language delay: II. Etiology of transient and persistent language difficulties. Journal of Speech Language and Hearing Research, 46, 561–575. CrossRef
go back to reference Bloom, L. (1993). The transition from infancy to language: Acquiring the power of expression. Cambridge, England: Cambridge University Press. Bloom, L. (1993). The transition from infancy to language: Acquiring the power of expression. Cambridge, England: Cambridge University Press.
go back to reference Bloom, L. (1998). Language acquisition in its developmental context. In W. Damon (Ed.) Handbook of child psychology, Vol. 2. Cognition, preparation and language (5th ed., pp. 309–370). New York: Wiley. Bloom, L. (1998). Language acquisition in its developmental context. In W. Damon (Ed.) Handbook of child psychology, Vol. 2. Cognition, preparation and language (5th ed., pp. 309–370). New York: Wiley.
go back to reference Bolton, P., Macdonald, H., Pickles, A. Rios, P., & Goode, S. (1994). A case–control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900. PubMedCrossRef Bolton, P., Macdonald, H., Pickles, A. Rios, P., & Goode, S. (1994). A case–control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900. PubMedCrossRef
go back to reference Charman, T., Baron-Cohen, S., Swettenham, J., Baird, G., Drew, A., & Cox, A. (2003a). Predicting language outcome in infants with autism and pervasive developmental disorders. The International Journal of Language and Communication Disorders, 38, 265–285. CrossRef Charman, T., Baron-Cohen, S., Swettenham, J., Baird, G., Drew, A., & Cox, A. (2003a). Predicting language outcome in infants with autism and pervasive developmental disorders. The International Journal of Language and Communication Disorders, 38, 265–285. CrossRef
go back to reference Charman, T., Drew, A., Baird, C., & Baird, G. (2003b). Measuring early language development in preschool children with autism spectrum disorders using the McArthur Communicative Development Inventory (Infant Form). Journal of Child Language, 30, 213–236. CrossRef Charman, T., Drew, A., Baird, C., & Baird, G. (2003b). Measuring early language development in preschool children with autism spectrum disorders using the McArthur Communicative Development Inventory (Infant Form). Journal of Child Language, 30, 213–236. CrossRef
go back to reference Coonrod, E., & Stone, W. L. (2004). Early concerns of parents of children with autistic and nonautistic disorders. Infants and Young Children, 17, 258–268. CrossRef Coonrod, E., & Stone, W. L. (2004). Early concerns of parents of children with autistic and nonautistic disorders. Infants and Young Children, 17, 258–268. CrossRef
go back to reference Dawson, G., Webb, S., Schellenberg, G. D., Dager, S., Friedman, S., Aylward, E., & Richards, T. (2002). Defining the broader phenotype of autism: Genetic, brain and behavioral perspectives. Development and Psychopathology, 14, 581–611. PubMedCrossRef Dawson, G., Webb, S., Schellenberg, G. D., Dager, S., Friedman, S., Aylward, E., & Richards, T. (2002). Defining the broader phenotype of autism: Genetic, brain and behavioral perspectives. Development and Psychopathology, 14, 581–611. PubMedCrossRef
go back to reference De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry, 7, 131–136. PubMedCrossRef De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child and Adolescent Psychiatry, 7, 131–136. PubMedCrossRef
go back to reference Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321. PubMedCrossRef Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321. PubMedCrossRef
go back to reference Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: Cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry, 38, 667–684. PubMedCrossRef Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: Cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry, 38, 667–684. PubMedCrossRef
go back to reference Gillberg, C., Gillberg, I. C., & Stefenburg, S. (1992). Siblings and parents of children with autism: A controlled population-based study. Developmental Medicine and Child Neurology, 34, 389–398. PubMedCrossRef Gillberg, C., Gillberg, I. C., & Stefenburg, S. (1992). Siblings and parents of children with autism: A controlled population-based study. Developmental Medicine and Child Neurology, 34, 389–398. PubMedCrossRef
go back to reference Goldfield, B., & Reznick, J. S. (1990). Early lexical acquisition: Rate, content, and the vocabulary spurt. Journal of Child Language, 17, 171–183. PubMedCrossRef Goldfield, B., & Reznick, J. S. (1990). Early lexical acquisition: Rate, content, and the vocabulary spurt. Journal of Child Language, 17, 171–183. PubMedCrossRef
go back to reference International Molecular Genetic Study Group of Autism Consortium (IMGSAC) (2001). A genomewide screen for autism: Strong evidence for linkage to chromosomes 2q, 7q and 16p. American Journal of Human Genetics, 69, 570–581. CrossRef International Molecular Genetic Study Group of Autism Consortium (IMGSAC) (2001). A genomewide screen for autism: Strong evidence for linkage to chromosomes 2q, 7q and 16p. American Journal of Human Genetics, 69, 570–581. CrossRef
go back to reference Kaufman, A. S., & Kaufman, N. L. (1983). Kaufman assessment battery for children (K-ABC). Circle Pines, MN: AGS. Kaufman, A. S., & Kaufman, N. L. (1983). Kaufman assessment battery for children (K-ABC). Circle Pines, MN: AGS.
go back to reference Leboyer M., Plumet M. H., Goldblum M. C., Perez-Diaz F., & Marchaland, C. (1995). Verbal versus visuospatial abilities in relatives of autistic females. Developmental Neuropsychology, 11, 139–155. CrossRef Leboyer M., Plumet M. H., Goldblum M. C., Perez-Diaz F., & Marchaland, C. (1995). Verbal versus visuospatial abilities in relatives of autistic females. Developmental Neuropsychology, 11, 139–155. CrossRef
go back to reference LeCouteur A., Bailey A., Goode S., Pickles A., Robertson S., Gottesman I., & Rutter, M. (1996). A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801. CrossRef LeCouteur A., Bailey A., Goode S., Pickles A., Robertson S., Gottesman I., & Rutter, M. (1996). A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801. CrossRef
go back to reference Lord C. (1995). Follow up of two-year-olds referred for possible Autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 36, 1365–1382. Lord C. (1995). Follow up of two-year-olds referred for possible Autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 36, 1365–1382.
go back to reference Lord C., Rutter M., & LeCouteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. PubMedCrossRef Lord C., Rutter M., & LeCouteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. PubMedCrossRef
go back to reference Narayan S., Moyes B., & Wolff, S. (1990). Family characteristics of autistic children: A further report. Journal of Autism and Developmental Disorders, 20, 523–535. PubMedCrossRef Narayan S., Moyes B., & Wolff, S. (1990). Family characteristics of autistic children: A further report. Journal of Autism and Developmental Disorders, 20, 523–535. PubMedCrossRef
go back to reference Ozonoff S., Rogers S. J., Farnham J. M., & Pennington, B. F. (1993). Can standard measures identify subclinical markers of autism?. Journal of Autism and Developmental Disorders, 23, 429–441. PubMedCrossRef Ozonoff S., Rogers S. J., Farnham J. M., & Pennington, B. F. (1993). Can standard measures identify subclinical markers of autism?. Journal of Autism and Developmental Disorders, 23, 429–441. PubMedCrossRef
go back to reference Pilowsky T., Yirmiya N., Shalev R., & Gross-Tsur, V. (2003). Language abilities of siblings of children with autism. Journal of Child Psychology and Psychiatry, 44, 914–925. PubMedCrossRef Pilowsky T., Yirmiya N., Shalev R., & Gross-Tsur, V. (2003). Language abilities of siblings of children with autism. Journal of Child Psychology and Psychiatry, 44, 914–925. PubMedCrossRef
go back to reference Plumet M. H., Goldblum M. C., & Leboyer, M. (1995). Verbal skills in relatives of autistic females. Cortex, 31, 723–733. PubMed Plumet M. H., Goldblum M. C., & Leboyer, M. (1995). Verbal skills in relatives of autistic females. Cortex, 31, 723–733. PubMed
go back to reference Rapin I., & Dunn, M. (2003). Update on the language disorders of individuals on the autistic spectrum. Brain and Development, 25, 166–172. PubMedCrossRef Rapin I., & Dunn, M. (2003). Update on the language disorders of individuals on the autistic spectrum. Brain and Development, 25, 166–172. PubMedCrossRef
go back to reference Reynell, J. K., & Grubber, C. P. (1990). Reynell developmental language scale. Los Angeles: Western Psychological Association. Reynell, J. K., & Grubber, C. P. (1990). Reynell developmental language scale. Los Angeles: Western Psychological Association.
go back to reference Rodrigue, J. R., Geffken, G. R., & Morgan, S. B. (1993). Perceived competence and behavioral adjustment of siblings of children with autism. Journal of Autism and Developmental Disorders, 23, 665–674. PubMedCrossRef Rodrigue, J. R., Geffken, G. R., & Morgan, S. B. (1993). Perceived competence and behavioral adjustment of siblings of children with autism. Journal of Autism and Developmental Disorders, 23, 665–674. PubMedCrossRef
go back to reference Silverman, J. M., Smith, C. J., Schmeidler, J., Hollander, E., Lawlor, B. A., Fitzgerald, M., Buxbaum, J. D., Delaney, K., & Galvin, P. (2002). System domains in autism and related conditions: Evidence for familiality. American Journal of Medical Genetics (Neuropsychiatric genetics), 114, 64–73. CrossRef Silverman, J. M., Smith, C. J., Schmeidler, J., Hollander, E., Lawlor, B. A., Fitzgerald, M., Buxbaum, J. D., Delaney, K., & Galvin, P. (2002). System domains in autism and related conditions: Evidence for familiality. American Journal of Medical Genetics (Neuropsychiatric genetics), 114, 64–73. CrossRef
go back to reference Smalley, S. L., & Asarnow, R. F. (1990). Brief report: Cognitive subclinical markers in autism. Journal of Autism and Developmental Disorders, 20, 271–278. PubMedCrossRef Smalley, S. L., & Asarnow, R. F. (1990). Brief report: Cognitive subclinical markers in autism. Journal of Autism and Developmental Disorders, 20, 271–278. PubMedCrossRef
go back to reference Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (1985). Vineland adaptive behavior scales. Circle Pines, MN: American Guidance Services. Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (1985). Vineland adaptive behavior scales. Circle Pines, MN: American Guidance Services.
go back to reference Spinath, F. M., Price, T. S., Dale, P. S., & Plomin, R. (2004). The genetic and environmental origins of language disability and ability. Child Development, 75, 445–454. PubMedCrossRef Spinath, F. M., Price, T. S., Dale, P. S., & Plomin, R. (2004). The genetic and environmental origins of language disability and ability. Child Development, 75, 445–454. PubMedCrossRef
go back to reference Szatmari, P., Jones, M. B., Tuff, L., Bartolucci, G., Fisman, S., & Mahoney, W. (1993). Lack of cognitive impairment in first-degree relatives of children with pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1264–1273. PubMedCrossRef Szatmari, P., Jones, M. B., Tuff, L., Bartolucci, G., Fisman, S., & Mahoney, W. (1993). Lack of cognitive impairment in first-degree relatives of children with pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1264–1273. PubMedCrossRef
go back to reference Tager-Flusberg, H., & Cooper, J. (1999). Present and future possibilities for defining a phenotype for specific language impairment. Journal of Speech, Language and Hearing Research, 42, 1001–1004. Tager-Flusberg, H., & Cooper, J. (1999). Present and future possibilities for defining a phenotype for specific language impairment. Journal of Speech, Language and Hearing Research, 42, 1001–1004.
go back to reference Tomblin, J. B., Hafeman, L. L., & O’Brien, M. (2003). Autism and autism risk in siblings of children with specific language impairment. International Journal of Language and Communication Disorders, 38(3), 235–250. PubMedCrossRef Tomblin, J. B., Hafeman, L. L., & O’Brien, M. (2003). Autism and autism risk in siblings of children with specific language impairment. International Journal of Language and Communication Disorders, 38(3), 235–250. PubMedCrossRef
go back to reference Wechsler, D. (1991). Wechsler intelligence scale for children. (3rd ed.). San Antonio, TX: Psychological Corporation (WISC-III). Wechsler, D. (1991). Wechsler intelligence scale for children. (3rd ed.). San Antonio, TX: Psychological Corporation (WISC-III).
go back to reference Wiig, E. H., Secord, W., & Semel, E. (1992). CELF-preschool: Clinical evaluation of language fundamentals—preschool version. San Antonio, TX: Psychological Corporation. Wiig, E. H., Secord, W., & Semel, E. (1992). CELF-preschool: Clinical evaluation of language fundamentals—preschool version. San Antonio, TX: Psychological Corporation.
go back to reference Yirmiya, N., Gamliel, I., Pilowsky, T., Baron-Cohen, S., Feldman, R., & Sigman, M. (2006). The development of siblings of children with autism at 4 and 14 months: Social engagement, communication, and cognition. Journal of Child Psychology and Psychiatry, 47, 511–523. PubMedCrossRef Yirmiya, N., Gamliel, I., Pilowsky, T., Baron-Cohen, S., Feldman, R., & Sigman, M. (2006). The development of siblings of children with autism at 4 and 14 months: Social engagement, communication, and cognition. Journal of Child Psychology and Psychiatry, 47, 511–523. PubMedCrossRef
go back to reference Yirmiya, N., Shaked, M., & Erel, O. (2001). Comparison of siblings of individuals with autism and siblings of individuals with other diagnoses: An empirical summary. In: E. Schopler, N. Yirmiya, C. Shulman, & L. M. Marcus (Eds.), The research basis for autism intervention (pp. 59–73). New York: Kluwer Academic/Plenum. Yirmiya, N., Shaked, M., & Erel, O. (2001). Comparison of siblings of individuals with autism and siblings of individuals with other diagnoses: An empirical summary. In: E. Schopler, N. Yirmiya, C. Shulman, & L. M. Marcus (Eds.), The research basis for autism intervention (pp. 59–73). New York: Kluwer Academic/Plenum.
Metagegevens
Titel
Cognitive and Verbal Abilities of 24- to 36-month-old Siblings of Children with Autism
Auteurs
Nurit Yirmiya
Ifat Gamliel
Michal Shaked
Marian Sigman
Publicatiedatum
01-02-2007
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0163-5