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08-03-2016 | Original Paper | Uitgave 7/2016

Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient?

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 7/2016

Auteurs:: Hannah Cholemkery, Juliane Medda, Thomas Lempp, Christine M. Freitag

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Abstract

To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals with ASD aged 3–21. Three clusters were observed. Most severely affected individuals regarding all core symptoms were allocated to cluster 2. Cluster 3 comprised moderate symptom severity of social communication impairments (SCI) and less stereotyped repetitive behavior (RRB). Minor SCI and relatively more RRB characterized cluster 1. This study offers support for both, a symptom profile, and a gradient model of ASD within the spectrum due to the sample included.

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Titel: Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient?
Auteurs:: Hannah Cholemkery
Juliane Medda
Thomas Lempp
Christine M. Freitag
Publicatiedatum: 08-03-2016
DOI: https://doi.org/10.1007/s10803-016-2760-2
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 7/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient?

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