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Gepubliceerd in: Quality of Life Research 8/2010

01-10-2010

Chemotherapy-related polyneuropathy may deteriorate quality of life in patients with B-cell lymphoma

Auteurs: Byung-Jo Kim, Ha-Rim Park, Hak Jae Roh, Du-Shin Jeong, Byung Soo Kim, Kun-Woo Park, S. Charles Cho, Yuen T. So, Sung Yong Oh, Seok Jin Kim

Gepubliceerd in: Quality of Life Research | Uitgave 8/2010

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Abstract

Purpose

This prospective study was performed to evaluate the effect of chemotherapy-related neurotoxicity on quality of life (QOL) of patients with lymphoma.

Methods

Thirty-two patients with diffuse large B-cell or follicular lymphoma without prior evidence of neuropathy were enrolled. Patients underwent the evaluations based on neuropathy symptom and disability score, nerve conduction studies, and SF-36 questionnaire for QOL assessment. They received six cycles of chemotherapy every three weeks, and all evaluations were repeated during and after the completion of 6th cycle.

Results

Sensory neuropathy-associated symptoms were observed in 27 patients (84.4%), and polyneuropathy was confirmed by nerve conduction study in 14 patients (43.8%). These patients with polyneuropathy showed worse QOL in domains mainly associated with physical health status including “physical function” compared to patients without polyneuropathy. There was a significant association of neuropathy symptom and disability scores with “bodily pain” and “vitality” of QOL domains. The serial evaluations of patients with neuropathy showed a worsening of QOL and neuropathy symptom scores during chemotherapy, then improvement of these values after chemotherapy. Thus, the final nerve conduction study confirmed the decrease in polyneuropathy compared to the 2nd evaluation (P = 0.032).

Conclusion

Chemotherapy-related polyneuropathy may deteriorate QOL of patients with lymphoma, mainly physical health-associated QOL.
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Metagegevens
Titel
Chemotherapy-related polyneuropathy may deteriorate quality of life in patients with B-cell lymphoma
Auteurs
Byung-Jo Kim
Ha-Rim Park
Hak Jae Roh
Du-Shin Jeong
Byung Soo Kim
Kun-Woo Park
S. Charles Cho
Yuen T. So
Sung Yong Oh
Seok Jin Kim
Publicatiedatum
01-10-2010
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 8/2010
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9670-0