Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

17-05-2017 | S.I. : Autism Inpatient Collection - Studying the Severely Affected

Characterization of Medication Use in a Multicenter Sample of Pediatric Inpatients with Autism Spectrum Disorder

Auteurs: Logan K. Wink, Ernest V. Pedapati, Ryan Adams, Craig A. Erickson, Kahsi A. Pedersen, Eric M. Morrow, Desmond Kaplan, Matthew Siegel, for the Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC)

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2018

Abstract

Nearly 11% of youth with Autism Spectrum Disorder (ASD) undergo psychiatric hospitalization, and 65% are treated with psychotropic medication. Here we characterize psychotropic medication usage in subjects enrolled in the Autism Inpatient Collection. Participant psychotropic medication usage rates topped 90% at admission and discharge, though there was a decline at 2-month follow-up. Antipsychotics, ADHD medications, and sleep aids were the most commonly reported classes of medications. The impact of age, gender, and non-verbal IQ on medication usage rates was minimal, though age and IQ may play a role in prescribing practices. Future work is indicated to explore medication usage trends, the impact of clinical factors on medication use rates, and the safety of psychotropic medications in youth with ASD.

vorige artikel Talking About Death or Suicide: Prevalence and Clinical Correlates in Youth with Autism Spectrum Disorder in the Psychiatric Inpatient Setting

volgende artikel Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD)

Alleen toegankelijk voor geautoriseerde gebruikers

Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 5, 485–491.

Christensen, D. L. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years- autism developmental disabilities monitoring network. Surveillance Summaries 65.

Erickson, C. A., Posey, D. J., Stigler, K. A., & McDougle, C. J. (2007). Pharmacologic treatment of autism and related disorders. Pediatric Annals, 36, 575–585.CrossRefPubMed

Fitzpatrick, S. E., Srivorakiat, L., Wink, L. K., Pedapati, E. V., & Erickson, C. A. (2016). Aggression in autism spectrum disorder: Presentation and treatment options. Neuropsychiatric Disease and Treatment, 12, 1525–1538. doi:10.2147/NDT.S84585.CrossRefPubMedPubMedCentral

King, B. H., et al. (2009). Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: Citalopram ineffective in children with autism. Archives of General Psychiatry, 66, 583–590. doi:10.1001/archgenpsychiatry.2009.30.CrossRefPubMedPubMedCentral

Lord, C., Rutter, M., DiLavore, P., Risis, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule, second edition (ADOS-2). Torrance: Western Psychological Services.

Mandell, D. S. (2008). Psychiatric hospitalization among children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 38, 1059–1065. doi:10.1007/s10803-007-0481-2.CrossRefPubMed

Marcus, R. N., et al. (2009). A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 1110–1119. doi:10.1097/CHI.0b013e3181b76658.CrossRefPubMed

McCracken, J. T., et al. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347, 314–321.CrossRefPubMed

McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics, 133, 872–883. doi:10.1542/peds.2013-3995.CrossRefPubMed

McGuire, K., et al. (2015). Psychiatric hospitalization of children with autism or intellectual disability: Consensus statements on best practices. Journal of the American Academy of Child and Adolescent Psychiatry, 54, 969–971. doi:10.1016/j.jaac.2015.08.017.CrossRefPubMedPubMedCentral

Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171.CrossRefPubMed

Owen, R., et al. (2009). Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics, 124, 1533–1540. doi:10.1542/peds.2008-3782.CrossRefPubMed

Park, S. Y., et al. (2016). Antipsychotic use trends in youth with autism spectrum disorder and/or intellectual disability: A meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 55(456–468), e4. doi:10.1016/j.jaac.2016.03.012.CrossRef

Politte, L. C., Henry, C. A., & McDougle, C. J. (2014). Psychopharmacological interventions in autism spectrum disorder. Harvard Review of Psychiatry, 22, 76–92. doi:10.1097/HRP.0000000000000030.CrossRefPubMed

Research Units on Pediatric Psychopharmacology Autism Network (2005). Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry 62, 1266–1274 doi:10.1001/archpsyc.62.11.1266.CrossRef

Roid, G. H., Miller, L. J., Pomplun, M., Koch, C. (2013). Leiter international performance scale, 3rd Edition. Wood Dail, IL: Stoelting.

Rutter, M., Bailey, A., Lord, C. (2003). Social communication questionnaire. Torrance: Western Psychological Services.

Saldana, S. N., et al. (2014). Antipsychotic polypharmacy in children and adolescents at discharge from psychiatric hospitalization. Pharmacotherapy, 34, 836–844. doi:10.1002/phar.1453.CrossRefPubMedPubMedCentral

Schubart, J. R., Camacho, F., & Leslie, D. (2014). Psychotropic medication trends among chidren and adolescents with autism psectrum disorder in the Medicaid program. Autism, 18, 631–637.CrossRefPubMed

Siegel, M., et al. (2015). The autism inpatient collection: methods and preliminary sample description. Molecular Autism, 6, 61. doi:10.1186/s13229-015-0054-8.CrossRefPubMedPubMedCentral

Siegel, M., & Gabriels, R. L. (2014). Psychiatric hospital treatment of children with autism and serious behavioral disturbance. Child and Adolescent Psychiatric Clinics of North America, 23, 125–142. doi:10.1016/j.chc.2013.07.004.CrossRefPubMed

Sparrow, S., Cicchetti, D., Balla, D.A. (2008). Vineland adaptive behaviors scales, 2nd Edition. Livonia: Pearson.

Spencer, D., et al. (2013). Psychotropic medication use and polypharmacy in children with autism spectrum disorders. Pediatrics, 132, 833–840. doi:10.1542/peds.2012-3774.CrossRefPubMedPubMedCentral

Vasa, R. A., et al. (2014). A systematic review of treatments for anxiety in youth with autism spectrum disorders. Journal of Autism and Developmental Disorders, 44, 3215–3229. doi:10.1007/s10803-014-2184-9.CrossRefPubMed

Wink, L. K., Erickson, C. A., & McDougle, C. J. (2010). Pharmacologic treatment of behavioral symptoms associated with autism and other pervasive developmental disorders. Current Treatment Options in Neurology, 12, 529–538. doi:10.1007/s11940-010-0091-8.CrossRefPubMed

Titel: Characterization of Medication Use in a Multicenter Sample of Pediatric Inpatients with Autism Spectrum Disorder
Auteurs: Logan K. Wink
Ernest V. Pedapati
Ryan Adams
Craig A. Erickson
Kahsi A. Pedersen
Eric M. Morrow
Desmond Kaplan
Matthew Siegel
for the Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC)
Publicatiedatum: 17-05-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3153-x

Andere artikelen Uitgave 11/2018

Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder

S.I. : Autism Inpatient Collection - Studying the Severely Affected

Development of the Emotion Dysregulation Inventory: A PROMIS®ing Method for Creating Sensitive and Unbiased Questionnaires for Autism Spectrum Disorder

SI: The Autism Inpatient Collection - Studying the Severely Affected

Differences of Symptom Distribution Across Adult Age in High Functioning Individuals on the Autism Spectrum Using Subscales of the Autism Spectrum Quotient

Open Access
Original Paper

Response to Distress Varies by Social Impairment and Familiarity in Infants at Risk for Autism

Original Paper

The Severe End of the Spectrum: Insights and Opportunities from the Autism Inpatient Collection (AIC)

Editorial

Risk Factors for Self-injurious Behavior in an Inpatient Psychiatric Sample of Children with Autism Spectrum Disorder: A Naturalistic Observation Study

S.I. : Autism Inpatient Collection - Studying the Severely Affected