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Scanning the Genome for Attention Deficit Hyperactivity Disorder

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Attention Deficit Hyperactivity Disorder

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

In the past decade, there have been exciting developments in the understanding of the genetic basis of susceptibility to attention deficit hyperactivity disorder (ADHD). This chapter reviews the genetic epidemiology (family, twin, and adoption studies) of ADHD and summarizes the neurobiological evidence (pharmacology, animal models, and neuroimaging studies) that points to particular candidate genes. Relevant findings from genetic studies of dopaminergic, serotonergic, and noradrenergic candidate genes are provided. New directions in the field are discussed briefly, such as the move to characterize endophenotypes, meta-analyses of association studies, and emerging genetic linkage studies.

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Authors and Affiliations

  1. Department of Psychiatry, Trinity College, Dublin, Ireland

    Aiveen Kirley MD, MRCPsych

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  1. Aiveen Kirley MD, MRCPsych
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  1. Kosair Children’s Hospital, Research Institute, Departments of Pediatrics, Pharmacology, and Toxicology, University of Louisville, Louisville, KY

    David Gozal MD

  2. Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY

    Dennis L. Molfese PhD

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Kirley, A. (2005). Scanning the Genome for Attention Deficit Hyperactivity Disorder. In: Gozal, D., Molfese, D.L. (eds) Attention Deficit Hyperactivity Disorder. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-891-9:041

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  • DOI: https://doi.org/10.1385/1-59259-891-9:041

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