Skip to main content

Can analysis of heart rate variability predict arrhythmias and antiarrhythmic effects?

  • Chapter
Practice and Progress in Cardiac Pacing and Electrophysiology

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 183))

Abstract

Heart rate variability is an interesting and intellectually challenging concept. Subtle nuances in R-R interval variations can, when appropriately processed, reveal information about the general balance of sympathetic and parasympathetic tone. Early studies, however, used relatively crude indices of heart rate variability. They showed that in patients with diabetic autonomic neuropathy variability was lost with the associated cardiac denervation [1]. Wolf et al. [2] showed that the presence of sinus arrhythmia in infarct survivors predicted a good long-term outcome. Since then there has been considerable interest in heart rate variability as, of all the many arrhythmogenic factors, autonomic tone is the least easily measured. At the present time there are a myriad of heart rate variability measures based on some form of dynamic ECG recording. Sinus rate variability and the Valsalva index have largely been superseded although it might be premature to abandon them; they are simple and robust [3, 4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Ewing D, Campbell I, Clarke B. Assesment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Int Med 1980; 92(2Pt2): 308–11.

    PubMed  CAS  Google Scholar 

  2. Wolf M, Varigos G, Hunt D et al. Sinus arrhythmia in acute myocardial infarction. Med J Austr 1978; 2(2): 52–3.

    CAS  Google Scholar 

  3. Stein P, Rich M, Rottman J et al. Stability of index of heart rate variability in patients with congestive heart failure. Am Heart J 1995; 129(5): 975–81.

    Article  PubMed  CAS  Google Scholar 

  4. Moser M, Lehofer M, Sedminek A et al. Heart rate variability as a prognostic tool in cardiology. A contribution to the problem from a theoretical point of view. Circulation 1994; 90(2): 1078–82.

    PubMed  CAS  Google Scholar 

  5. Kleiger RE, Miller P, Bigger T et al. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987; 59: 256–62.

    Article  PubMed  CAS  Google Scholar 

  6. Bigger J, Kleiger R, Fleiss J et al. Components of heart rate variability measured during healing of acute myocardial infarction. Am J Cardiol 1988; 61(4): 208–15.

    Article  PubMed  Google Scholar 

  7. Cripps T, Malik M, Farrell T et al. Prognostic value of reduced heart rate variability after myocardial infarction: Clinical evaluation of a new analysis method. Br Heart J 1991; 65(1): 14–9.

    Article  PubMed  CAS  Google Scholar 

  8. Casolo G, Stroder P, Signorini C et al. Heart rate variability during the acute phase of myocardial infarction. Circulation 1992; 85(6): 2073–9.

    PubMed  CAS  Google Scholar 

  9. Algra A, Tijssen J, Roelandt J et al. Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death. Circulation 1993; 88(1): 180–5.

    PubMed  CAS  Google Scholar 

  10. Tsuji H, Venditti F, Manders E et al. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 1994; 90(2): 878–83.

    CAS  Google Scholar 

  11. Viskin S, Beihassen B. Noninvasive and invasive strategies for the prevention of sudden death after myocardial infarction. Value, limitations and implications for therapy. Drugs 1992; 44(3): 336–55.

    Article  PubMed  CAS  Google Scholar 

  12. Araya-Gomez V, Gonzalez-Hermosillo J, Casanova-Garces J et al. Identification of patients at risk of malignant arrhythmia in the 1st year after myocardial infarction (Spanish). Archivos del Instituto de Cardiologia de Mexico 1994; 64(2): 145–59.

    PubMed  CAS  Google Scholar 

  13. Fei L, Statters D, Hnatkova K et al. Change of autonomic influence on the heart immediately before the onset of spontaneous idiopathic ventricular tachycardia. J Am Coll Cardiol 1994; 24(6): 1515–22.

    Article  PubMed  CAS  Google Scholar 

  14. Vybiral T, Glaeser D, Goldberger A et al. Conventional heart rate variability analysis of ambulatory electrocardiographic recordings fails to predict imminent ventricular fibrillation. J Am Coll Cardiol 1993; 22(2): 557–65.

    Article  PubMed  CAS  Google Scholar 

  15. Leenhardt A, Glaser E, Burguera M et al. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994; 89(1): 206–15.

    PubMed  CAS  Google Scholar 

  16. Carter J, Childers R. Torsade de pointes complication acute myocardial infarction: the importance of autonomic dysfunction as assessed by heart rate variability. Clin Cardiol 1992; 15(10): 769–72.

    Article  PubMed  Google Scholar 

  17. Counihan P, Fei L, Bashir Y et al. Assessment of heart rate variability in hypertrophic cardiomyopathy. Association with clinical and prognostic features. Circulation 1993; 88(4 Pt 1): 1682–90.

    PubMed  CAS  Google Scholar 

  18. Niemela M, Airaksinen K, Huikuri H. Effect of beta-blockade on heart rate variability in patients with coronary artery disease. J Am Coll Cardiol 1994; 23(6): 1370–7.

    Article  PubMed  CAS  Google Scholar 

  19. Klingenheben T, Hohnloser S. [Effect of Sotalol on heart rate variability in patients with symptomatic, complex ventricular arrhythmias] [German]. Zeitsh Kardiol 1994; 83(4): 293–8.

    CAS  Google Scholar 

  20. Cowan M, Pike K, Burr R et al Description of time- and frequency-domain-based measures of heart rate variability in individuals taking antiarrhythmic, beta-blockers, calcium channel blockers, and/or antihypertensive drugs after sudden cardiac arrest. J Electrocardiol 1993; 26(Suppl): 1–13.

    PubMed  Google Scholar 

  21. Stein P, Rottman J, Kuru T et al. Effect of moricizine on heart rate variability in normal subjects. Int J Cardiol 1995; 48(1): 59–65.

    Article  PubMed  CAS  Google Scholar 

  22. Lombardi F, Torzillo D, Sandrone G et al. Beta-blocking effect of propafenone based on spectral analysis of heart rate variability. Am J Cardiol 1992; 70(11): 1028–34.

    Article  PubMed  CAS  Google Scholar 

  23. Zuanetti G, Latini R, Neilson J et al. Heart rate variability in patients with ventricular arrhythmias: effect of antiarrhythmic drugs. Antiarrhythmic Drug Evaluation Group (ADEG). J Am Coll Cardiol 1991; 17(3): 604–12.

    Article  PubMed  CAS  Google Scholar 

  24. Pedretti R, Colombo E, Braga SS et al. Effect of thrombolysis on heart rate variability and life-threatening ventricular arrhythmias in survivors of acute myocardial infarction. J Am Coll Cardiol 1994; 23(1): 19–26.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Campbell, R.W.F. (1996). Can analysis of heart rate variability predict arrhythmias and antiarrhythmic effects?. In: Oto, M.A. (eds) Practice and Progress in Cardiac Pacing and Electrophysiology. Developments in Cardiovascular Medicine, vol 183. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0219-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0219-0_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6582-5

  • Online ISBN: 978-94-009-0219-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics