Abstract
A large number of plants can cause adverse effects when ingested by animals or people. Plant toxicity is due to a wide diversity of chemical toxins that include alkaloids, glycosides, proteins and amino acids. There are several notable toxic plants for which a specific chemical responsible for toxicity has not been determined. There are many examples of species differences in terms of their sensitivity to intoxication from plants. Pets, such as dogs and cats, and people, especially children, are frequently exposed to the same toxic plants due to their shared environments. On the other hand, livestock are exposed to toxic plants that are rarely involved in human intoxications due to the unique environments in which they are kept. Fortunately, adverse effects often do not occur or are generally mild following most toxic plant ingestions and no therapeutic intervention is necessary. However, some plants are extremely toxic and ingestion of small amounts can cause rapid death. The diagnosis of plant intoxication can be challenging, especially in veterinary medicine where a history of exposure to a toxic plant is often lacking. Analytical tests are available to detect some plant toxins, although their diagnostic utility is often limited by test availability and timeliness of results. With a few notable exceptions, antidotes for plant toxins are not available. However, general supportive and symptomatic care often is sufficient to successfully treat a symptomatic patient.
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Palmer M, Betz JM (2006) Plants. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 1577–1602
Spoerke Jr, DG, Smolinske SC (1990) Toxicity of Houseplants. CRC Press, Boca Raton, FL
Brent J, Phillips SD, Wallace KL, Donovan JW, Burkhart KK (2005) Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient. Elsevier Mosby, Philadelphia, PA
Burrows GE, Tyrl RJ (2001) Toxic Plants of North America Iowa State University Press, Ames, IA
Bronstein AC, Spyker DA, Cantilena Jr, LR, Green JL, Rumack BH, Heard SE (2008) 2007 Annual Report of the American Association of Poison Control Centers’ Data System (NPDS): 25th Annual Report. Clin Toxicol 46: 927–1057
Buck WB (1992) Top 25 generic agents involving dogs and cats managed by the National Animal Poison Control Center in 1992. In: JD Bonagura RW Kirk (eds): Kirk’s Current Veterinary Therapy XII: Small Animal Practice. WB Saunders, Philadelphia, PA, 210
Galey FD, Holstedge DM, Plumlee KH, Tor E, Johnson B, Anderson ML, Blanchard PC, Brown F (1996) Diagnosis of oleander poisoning in livestock. J Vet Diagn Invest 8: 358–364
Alden CL, Fosnaugh CJ, Smith JB, Mohan R (1977) Japanese yew poisoning of large domestic animals in the Midwest. J Am Vet Med Assoc 170: 314–316
James LF (1988) Introduction. In: LF James, MH Ralphs, DB Nielson (eds): The Ecology and Economic Impact of Poisonous Plants on Livestock Production. Westview Press, Boulder, CO, 1–4
Panter KE, Gardner DR, Lee ST, Pfister JA, Ralphs MH, Stegelmeier BL, James LF (2007) Important poisonous plants of the United States. In: RC Gupta (ed): Veterinary Toxicology: Basic and Applied Principles. Elsevier Academic Press, Amsterdam, 825–872
Bythe LL, Craig AM (1994) Role of the liver in detoxification of poisonous plants. Vet Hum Toxicol 36: 564–566
Knight AP (1988) Poisonous plants: Oleander poisoning. Compend Food Animal 10: 262–263
Hung OL, Lewin NA (2001) Herbal preparations. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 664–684
Debelle FD, Vanherweghem JL, Nortier JL (2008) Aristolochic acid nephropathy: A worldwide problem. Kidney Int 74: 158–169
Sudekum M, Poppenga RH, Raju N, Braselton WE Jr (1992) Pennyroyal oil toxicosis in a dog. J Am Vet Med Assoc 200: 817–818
Bischoff K, Guale F (1998) Australian tea tree (Melaleuca alternifolia) oil poisoning in three purebred cats. J Vet Diagn Invest 10: 208–210
Gwaltney-Brant SM, Albretsen JC, Khan SA (2000) 5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989–1999). J Am Vet Med Assoc 216: 1937–1940
Cheeke PR (1998) Natural Toxicants in Feeds, Forages and Poisonous Plants. Interstate Publishers, Danville, IL
Audi J, Belson M, Patel M, Schier J, Osterloh J (2005) Ricin poisoning: A comprehensive review. J Am Med Assoc 294: 2342–2351
Hovda LR (2009) Toxin exposures in small animals. In: JD Bonagura, DC Twedt (eds): Current Veterinary Therapy XIV. Saunders Elsevier, St. Louis, MO, 92–94
Nielson DB, Rimbey NR, James LF (1988) Economic considerations of poisonous plants on livestock. In: LF James, MH Ralphs, DB Nielson (eds): The Ecology and Economic Impact of Poisonous Plants on Livestock Production. Westview Press, Boulder, CO, 5–15
Reynolds T (2005) Hemlock alkaloids from Socrates to poison aloes. Phytochemistry 66: 1399–1406
Vetter J (2004) Poison hemlock (Conium maculatum L.). Food Chem Toxicol 42: 1373–1382
Panter KE, Keeler RF (1988) The hemlocks: Poison hemlock (Conium maculatum) and water-hemlock (Cicuta spp.). In: LF James, MH Ralphs, DB Nielson (eds): The Ecology and Economic Impact of Poisonous Plants on Livestock Production. Westview Press, Boulder, CO, 207–225
Galey FD, Holstedge DM, Fisher EG (1992) Toxicosis in dairy cattle exposed to poison hemlock (Conium maculatum) in hay: Isolation of Conium alkaloids in plants, hay, and urine. J Vet Diagn Invest 4: 60–64
Jessup DA, Boermans HJ, Kock ND (1986) Toxicosis in tule elk caused by ingestion of poison hemlock. J Am Vet Med Assoc 189: 1173–1175
Edmonds LD, Selby LA, Case, AA (1972) Poisoning and congenital malformations associated with the consumption of poison hemlock by sows. J Am Vet Med Assoc 160: 1319–1324
Panter KE, Keeler RF, Buck WB (1985) Congenital skeletal malformations induced by maternal ingestion of Conium maculatum (poison hemlock) in newborn pigs. J Am Vet Med Assoc 46: 2064–2066
Stegelmeier BL, Gardner DR, Davis TZ (2009) Livestock poisoning with pyrrolizidine alkaloid-containing plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). Rangelands 31: 35–37
Stewart MJ, Steenkamp V (2001) Pyrrolizidine poisoning: A neglected area in human toxicology. Ther Drug Monit 23: 698–708
Stegelmeier BL, Gardner DR, James LF, Molyneux RJ (1996) Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses. J Vet Diagn Invest 8: 81–90
Craig AM, Pearson EG, Meyer C, Schmitz JA (1991) Clinicopathologic studies of tansy ragwort toxicosis in ponies: Sequential serum and histopathologic changes. Equine Vet Sci 11: 261–371
Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2007) Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. Saunders Elsevier, Edinburgh
Moore RE, Knottenbelt D, Matthews JB, Beynon RJ, Whitfield PD (2008) Biomarkers for ragwort poisoning in horses: Identification of protein targets. BMC Vet Res 4: 30–41
Shupe JL, James LF (1983) Teratogenic plants. Vet Hum Toxicol 25: 415–421
Knight AP (1989) Veratrum californicum poisoning. Compendium 11: 528–529
Incardona JP, Gaffield W, Lange Y, Cooney A, Pentchev PG, Liu S, Watson JA, Kapur RP, Roelink H (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev Biol 224: 440–452
Greene GS, Patterson SG, Warner E (1996) Ingestion of angel’s trumpet: An increasingly common source of toxicity. Southern Med J 89: 365–369
Wiebe TH, Sigurdson ES, Katz LY (2008) Angel’s trumpet (Datura stramonium) poisoning and delirium in adolescents in Winnipeg, Manitoba: Summer 2006. Paediatr Child Health 13: 193–196
Majak W, McDiarmid RE, Hall JW (1981) The cyanide potential of Saskatoon serviceberry (Amelanchier alnifolia) and chokecherry (Prunus virginiana). Can J Anim Sci 61: 681–686
Holstedge CP, Isom GE, Kirk MA (2006) Cyanide and hydrogen sulfide. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 1712–1724
Vetter J (2000) Plant cyanogenic glycosides. Toxicon 38: 11–36
Adams LG, Dollahite JW, Romane WM, Bullard TL, Bridges CH (1969) Cystitis and ataxia associated with sorghum ingestion by horses. J Am Vet Med Assoc 155: 518–524
Anderson LA, Joubert JP, Schultz RA, Kellerman TS, Pienaar BJ (1987) Experimental evidence that the active principle of the poisonous plant Thesium lineatum L.f. (Santalaceae) is a bufadienolide. Onderstepoort J Vet Res 54: 645–650
Baskin SI, Czerwinski SE, Anderson JB, Sebastian MM (2007) Cardiovascular toxicity. In: RC Gupta (ed): Veterinary Toxicology: Basic and Applied Principles. Elsevier Academic Press, Amsterdam, 193–205
Kozikowski TA, Magdesian G, Puschner G (2009) Oleander intoxication in New World camelids: 12 cases (1995–2006). J Am Vet Med Assoc 235: 305–310
Jortani S, Helm RA, Valdes R Jr (1996) Inhibition of Na, K-ATPase by oleandrin and oleandrogenin, and their detection by digoxin immunoassays. Clin Chem 42: 1654–1658
Tor ER, Filigenzi MS, Puschner B (2005) Determination of oleandrin in tissues and biological fluids by liquid chromatography-electrospray tandem mass spectrometry. J Agric Food Chem 53: 4322–4325
Eddleston M, Rajapakse S, Rajakanthan, Jayalath S, Sjöström L, Santharaj W, Thenabadu PN, Sheriff MH, Warrell DA (2000) Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: A randomised controlled trial. Lancet 355: 967–972
Roberts DM, Buckley NA (2006) Antidotes for acute cardenolide (cardiac glycoside) poisoning. Cochrane Database Syst Rev Oct 18; (4):CD005490
Vetter J (2009) A biological hazard of our age: Bracken fern [Pteridium aquilinum (L.) Kuhn]: A review. Acta Vet Hung 57: 183–196
Raisbeck MF, Dahl ER, Sanchez DA, Belden EL, O’Toole D (1993) Naturally occurring selenosis in Wyoming. J Vet Diagn Invest 5: 84–87
O’Toole D, Raisbeck MF (1995) Pathology of experimentally induced chronic selenosis (alkali disease) in yearling cattle. J Vet Diagn Invest 7: 364–373
Mouser P, Filigenzi MS, Puschner B, Johnson V, Miller MA, Hooser SB (2007) Fatal ricin toxicosis in a puppy confirmed by liquid chromatography/mass spectrometry when using ricine as a marker. J Vet Diagn Invest 19: 216–220
Albretson JC, Gwaltney-Brant SM, Khan SA (2000) Evaluation of castor bean toxicosis in dogs: 98 cases. J Am Anim Hosp Assoc 36: 229–233
Olsnes S, Kozlov JV (2001) Ricin. Toxicon 39: 1723–1728
Naude TW, Naidoo V (2007) Oxalates-containing plants. In: RC Gupta (ed): Veterinary Toxicology: Basic and Applied Principles. Elsevier Academic Press, Amsterdam, 880–891
Anderson GA, Mount ME, Vrins AA, Ziemer EL (1983) Fatal acorn poisoning in a horse: Pathologic findings and diagnostic considerations. J Am Vet Med Assoc 182: 1105–1110
Kinde H (1988) A fatal case of oak poisoning in a double-wattled cassowary (Casuarius casuarius). Avian Dis 32: 849–851
Gardner DR, Molyneux RJ, James LF, Panter KE, Stegelmeier BL (1994) Ponderosa pine needle-induced abortion in beef cattle: Identification of isocupressic acid as the principal active compound. J Agric Food Chem 42: 756–761
James LF, Short RE, Panter KE, Molyneux RJ, Stuart LD, Bellows RA (1989) Pine needle abortion in cattle: A review and report of 1973–1984 research. Cornell Vet 79: 39–52
Verhoeff J, Hajer R, van den Ingh TSGAM (1985) Onion poisoning of young cattle. Vet Rec 117: 497–498
Pierce KR, Joyce JR, England RB, Jones LP (1972) Acute hemolytic anemia caused by wild onion poisoning in horses. J Am Vet Med Assoc 160: 323–327
Solter P, Scott R (1987) Onion ingestion and subsequent Heinz body anemia in a dog: A case report. J Am Anim Hosp Assoc 23: 544–546
Kobayashi K (1981) Onion poisoning in the cat. Feline Prac 11: 22–27
Robertson JE, Christopher MM, Rogers QR (1998) Heinz body formation in cats fed baby food containing onion powder. J Am Vet Med Assoc 8: 1260–1266
Hung OL, Lewin NA (2006) Herbal preparations. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 664–684
Pfister JA (1988) Nitrate intoxication of ruminant livestock. In: LF James, MH Ralphs, DB Nielson (eds): The Ecology and Economic Impact of Poisonous Plants on Livestock Production. Westview Press, Boulder, CO, 233–259
Nicholson SS (2007) Nitrate and nitrate-accumulating plants. In: RC Gupta (ed.): Veterinary Toxicology: Basic and Applied Principles. Elsevier Academic Press, Amsterdam, 876–879
Hall JO (2004) Lily. In: KH Plumlee (ed.): Clinical Veterinary Toxicology. Mosby, St. Louis, MO, 433–435
Rumbeiha WK, Francis JA, Fitzgerald SD, Nair MG, Holan K, Bugyei KA, Simmons H (2004) A comprehensive study of Easter lily poisoning in cats. J Vet Diagn Invest 16: 527–541
Langston CE (2002) Acute renal failure caused by lily ingestion in six cats. J Am Vet Med Assoc 220: 49–52
Morrow CM, Valli VE, Volmer PA, Eubig PA (2005) Canine renal pathology associated with grape or raisin ingestion: 10 cases. J Vet Diagn Invest 17: 223–231
Eubig PA, Brady MS, Gwaltney-Brant SM, Khan SA, Mazzaferro EM, Morrow CM (2005) Acute renal failure in dogs after the ingestion of grapes or raisins: A retrospective evaluation of 43 dogs (1992–2002). J Vet Intern Med 19: 663–674
Plumlee KH (2004) Macadamia nuts. In: KH Plumlee (ed.): Clinical Veterinary Toxicology. Mosby, St. Louis, MO, 435–436
Beasley VR, Dorman DC (1990) Management of toxicoses. In: VR Beasley (ed.): Veterinary Clinics of North America: Toxicology of Selected Pesticides, Drugs, and Chemicals. W.B. Saunders, Philadelphia, PA, 307–337
Flomenbaum NE, Goldfrank LR, Hoffman RS, Howland MA, Lewin NA, Nelson LS (2006) Principles of managing the poisoned or overdosed patient. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 42–50
Drellich S, Aldrich J (2006) Initial management of the acutely poisoned patient. In: ME Peterson, PA Talcott (eds): Small Animal Toxicology. Saunders Elsevier, St. Louis, MO, 45–59
Christophersen ABJ, Hoegberg LCG (2006) Techniques used to prevent gastrointestinal absorption. In: NE Flomenbaum, MA Howland, LR Goldfrank, NA Lewin, RS Hoffman, LS Nelson (eds): Goldfrank’s Toxicologic Emergencies. McGraw Hill, New York, NY, 109–123
Peterson ME (2006) Toxicological decontamination. In: ME Peterson, PA Talcott (eds): Small Animal Toxicology. Saunders Elsevier, St. Louis, MO, 127–141
American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists (2005) Position paper: Single-dose activated charcoal. Clin Toxicol 43: 61–87
Barr AC (2004) Household and garden plants. In: ME Peterson, PA Talcott (eds): Small Animal Toxicology. Saunders Elsevier, St. Louis, MO, 345–410
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Poppenga, R.H. (2010). Poisonous plants. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 100. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8338-1_4
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DOI: https://doi.org/10.1007/978-3-7643-8338-1_4
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