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Inhalation toxicology

  • Chapter
Molecular, Clinical and Environmental Toxicology

Part of the book series: Experientia Supplementum ((EXS,volume 100))

Abstract

Inhalation of gases, vapors and can cause a wide range of adverse health effects, ranging from simple irritation to systemic diseases. The large number of chemicals and complex mixtures present in indoor and outdoor air coupled with the introduction of new materials such as nanoparticles and nanofibers, is an area of growing concern for human health. Animal-based assays have been used to study the toxic effects of chemicals for many years. However, even so, very little is known about the potential toxicity of the vast majority of inhaled chemicals. As well as new or refined OECD test guidelines, continuing scientific developments are needed to improve the process of safety evaluation for the vast number of chemicals and inhaled materials. Although studying the toxic effects of inhaled chemicals is more challenging, promising in vitro exposure techniques have been recently developed that offer new possibilities to test biological activities of inhaled chemicals under biphasic conditions at the air liquid interface. This chapter gives an overview of inhalation toxicology as well as focusing on the potential application of in vitro methods for toxicity testing of airborne pollutants.

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Author information

Authors and Affiliations

  1. Chemical Safety and Applied Toxicology (CSAT) Laboratories, School of Risk and Safety Sciences, The University of New South Wales, Sydney, NSW 2052, Australia

    Amanda Hayes

  2. Department of Occupational Health, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Shahnaz Bakand (Visiting Research Fellow)

  3. School of Risk and Safety Sciences, University of New South Wales, Sydney, NSW, 2052, Australia

    Shahnaz Bakand (Visiting Research Fellow)

Authors
  1. Amanda Hayes
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  2. Shahnaz Bakand
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Editor information

Editors and Affiliations

  1. Federal Institute for Risk Assessment, Thielallee 88-92, 14195, Berlin, Germany

    Andreas Luch

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Hayes, A., Bakand, S. (2010). Inhalation toxicology. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 100. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8338-1_13

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