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Current State for Clinical Use of Stem Cells and Platelet-Rich Plasma

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Bio-orthopaedics

Abstract

Innovative biologic therapies continue to evolve for the treatment of orthopedic injuries. Platelet-rich plasma (PRP) and stem cells are at the forefront of these innovations designed to enhance the repair of tissues with high healing potential or augment the repair of tissues with limited healing potential and vascularity such as tendons, ligaments, and cartilage. The multipotency of these cells and their ability to modulate cellular signaling pathways provide promising therapeutic options, where traditional conservative or operative therapies have failed to achieve success. Basic science research has paved the way and affirmed proof of concept for utilizing these compounds as inflammatory regulators and biologic scaffolds for cellular maturation. But, initial clinical results, limited in number and power, have not been as convincing. Large-scale clinical trials with close follow-up are needed to clarify indications, dosing, cellular composition, safety, and overall efficacy.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Center for Sports Medicine, University of Pittsburgh, 3200 Water Street, Pittsburgh, PA, 15203, USA

    Volker Musahl, Thomas P. Pfeiffer & Jeremy M. Burnham

  2. Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Ave., Pittsburgh, PA, 15213, USA

    Conor I. Murphy & Gregory V. Gasbarro

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  1. Volker Musahl
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  2. Conor I. Murphy
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  3. Thomas P. Pfeiffer
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  4. Jeremy M. Burnham
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  5. Gregory V. Gasbarro
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Correspondence to Volker Musahl .

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Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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Musahl, V., Murphy, C.I., Pfeiffer, T.P., Burnham, J.M., Gasbarro, G.V. (2017). Current State for Clinical Use of Stem Cells and Platelet-Rich Plasma. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_8

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