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Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions

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Bio-orthopaedics

Abstract

Several techniques have been used during the years to treat chondral and osteochondral lesions. Among them, the use of biomaterials as scaffolds, able to provide a three-dimensional support for cell ingrowth and differentiation is nowadays widespread. The implantation of these 3D matrixes combined with differentiated cells, such as previously harvested and culture-expanded chondrocytes, produced satisfactory results for the treatment of chondral defects of the knee. However, the need for two different surgical procedures, with higher costs and discomfort for the patients, promoted the development of one-step techniques, which took advantage of scaffolds able to act themselves as stimuli for an “in situ” tissue regeneration. This cell-free approach was introduced into clinical use both to address chondral defects or osteochondral one, thanks to the development of multilayered products aimed at treating the entire osteochondral unit. This chapter aim at reviewing the evidence regarding the clinical application of acellular biomaterials for the treatment of chondral and osteochondral defects.

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Authors and Affiliations

  1. I Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy

    F. Perdisa, A. Sessa, G. Filardo & M. Marcacci

  2. Nano-Biotechnology Laboratory, I Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy

    E. Kon

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  1. F. Perdisa
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  2. A. Sessa
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  3. G. Filardo
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  4. M. Marcacci
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  5. E. Kon
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Correspondence to E. Kon .

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Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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Perdisa, F., Sessa, A., Filardo, G., Marcacci, M., Kon, E. (2017). Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_11

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