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Embryology and Anatomy of Hypospadias

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Hypospadias Surgery

Abstract

The embryology of the urogenital region remains controversial and confusing, in part related to the fact that observations have been extrapolated to the human from many different species. There are reports in the literature describing mice (van der Werff et al. 2000), rats (Forsberg 1961; Kluth et al. 1988), red squirrels (Barnstein and Mossman 1938), sheep (Tourneux 1888), pigs (van der Putte and Neeteson 1983), dogs (Kanagasuntheram and Anandaraja 1960) and humans (Nievelstein et al. 1998; de Vries and Friedland 1987).

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References

  • Altemus AR, Hutchins GM: Development of the human anterior urethra. J Urol. 1991; 146:1085–1093.

    PubMed  CAS  Google Scholar 

  • Anderson CA, Clark RL: External genitalia of the rat: normal development and the histogenesis of 5-alpha-reductase inhibitor-induced abnormalities. Teratology. 1990; 42: 483–496.

    Article  PubMed  CAS  Google Scholar 

  • Arey LB: Developmental anatomy, 7th edn. Saunders, Philadelphia, 1965.

    Google Scholar 

  • Barnstein NJ, Mossman HW: The origin of the penile urethra and bulbo-urethral glands with particular reference to the red squirrel (Tamiasciurus hudsonicus). Anat Rec. 1938; 72:67–85.

    Article  Google Scholar 

  • Baskin LS: Hypospadias and urethral development. J Urol. 2000; 163:951–956.

    Article  PubMed  CAS  Google Scholar 

  • Ben-Ari J, Merlob P, Mimouni F, et al: Characteristics of the male urethra in the newborn penis. J Urol. 1985; 134:521–522.

    PubMed  CAS  Google Scholar 

  • Clarnette TD, Sugita Y, Hutson JM: Genital anomalies in human and animal models reveal the mechanisms and hormones governing testicular descent. Br J Urol. 1997; 79:99–112.

    Article  PubMed  CAS  Google Scholar 

  • Cook WA, Stephens FD: Pathoembryology of the urinary tract. In: King LR (ed) Urological surgery in neonates and young infants. Saunders, Philadelphia, 1988; pp 1–23.

    Google Scholar 

  • de Vries PA, Friedland GW: The staged sequential development of the anus and rectum in human embryos and fetuses. J Pediatr Surg. 1987; 9:755–769.

    Article  Google Scholar 

  • England MA: A colour atlas of life before birth. Normal fetal development. Wolfe Medical Publications, Weert, Netherlands; 1983.

    Google Scholar 

  • Forsberg JG: On the development of the cloaca and the perineum and the formation of the urethral plate in female rat embryos. J Anat. 1961; 95:423–435.

    PubMed  CAS  Google Scholar 

  • Glenister TW: The origin and fate of the urethral plate in man. J Anat. 1954;88:413–425.

    PubMed  CAS  Google Scholar 

  • Glenister TW: A correlation of the normal and abnormal development of the penile urethra and of the infra-umbilical abdominal wall. Br J Urol. 1958; 30:117–126.

    Article  PubMed  CAS  Google Scholar 

  • Kanagasuntheram R, Anandaraja S: Development of the terminal urethra and prepuce in the dog. J Anat. 1960; 94: 121–129.

    PubMed  CAS  Google Scholar 

  • Kluth D, Lambrecht W, Reich P: Pathogenesis of hypospadias — more questions than answers. J Pediatr Surg. 1988; 23: 1095–1101.

    Article  PubMed  CAS  Google Scholar 

  • Moore KL, Persaud TVN: The developing human, 5th edn. Saunders, Philadelphia, 1993.

    Google Scholar 

  • Nievelstein RAJ, van der Werff JFA, Verbeek FJ, et al: Normal and abnormal embryonic development of the anorectum in human embryos. Teratology. 1998; 57:70–78.

    Article  PubMed  CAS  Google Scholar 

  • Paidas CN, Morreale RF, Holoski KM, et al: Septation and differentiation of the embryonic human cloaca. J Pediatr Surg. 1999; 34:877–884.

    Article  PubMed  CAS  Google Scholar 

  • Penington EC, Hutson JM: The cloacal plate — the missing link in anorectal and urogenital development. BJU Int. 2002; 89:726–732.

    Article  PubMed  CAS  Google Scholar 

  • Penington EC, Hutson JM: The urethral plate — does it grow into the genital tubercle or with it? BJU. Int. 2002; 89:733–739.

    CAS  Google Scholar 

  • Penington EC: MD Thesis, University of Melbourne, 2002.

    Google Scholar 

  • Pohlman AG: The development of the cloaca in human embryos. Am J Anat. 1911; 12:1–26.

    Article  Google Scholar 

  • Qi BQ, Williams A, Beasley S, et al: Clarification of the process of separation of the cloaca into rectum and urogenital sinus in the rat embryo. J Pediatr Surg. 2000; 35:1810–1816.

    Article  PubMed  CAS  Google Scholar 

  • Rowsell AR, Morgan BDE: Hypospadias and the embryogen-esis of the penile urethra. Br J Plastic Surg. 1987; 40: 201–206.

    Article  CAS  Google Scholar 

  • Sadler TW: Langman’s medical embryology, 6th edn. Williams and Wilkins, Baltimore, 1990, pp 237–259.

    Google Scholar 

  • Setchell BP: Reproduction in male marsupials. In: Stone-house B, Gilmore G (eds): The biology of marsupials. Macmillan, London, 1977; pp 411–455.

    Google Scholar 

  • Stephens FD, Smith ED, Hutson JM: Congenital anomalies of the kidney, urinary and genital tracts, 2nd edn. Dunitz, London, 2002.

    Google Scholar 

  • Tourneux F: Sur les premiers développements du cloaque du tubercule génital et de l’anus chez l’embryon de mouton. Anat Physiol. 1888; 24:503–517.

    Google Scholar 

  • Van der Putte SCJ, Neeteson FA: The normal development of the anorectum in the pig. Acta Morphol Neerl Scand. 1983; 21:107–132.

    PubMed  Google Scholar 

  • van der Werff JFA, Nievelstein RAJ, Brands E, et al: Normal development of the male anterior urethra. Teratology 2000;61:172–183.

    Article  PubMed  Google Scholar 

  • Vermeij-Keers C, Hartwig NG, vander Werff, JFA: Embryonic development of the ventral body wall and its congenital malformations. Semin Pediatr Surg. 1996; 5:82–89.

    PubMed  CAS  Google Scholar 

  • Wood-Jones F: The nature of the malformations of the rectum and urogenital passages. BMJ. 1904; 2:1630–1634.

    Article  PubMed  CAS  Google Scholar 

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Hutson, J.M., Penington, B.C. (2004). Embryology and Anatomy of Hypospadias. In: Hadidi, A.T., Azmy, A.F. (eds) Hypospadias Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07841-9_5

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  • DOI: https://doi.org/10.1007/978-3-662-07841-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07843-3

  • Online ISBN: 978-3-662-07841-9

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