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Immunological and Molecular Classification of Mucosa-Associated Lymphoid Tissue Lymphoma

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New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 142))

Abstract

Malignant B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type is now considered to be a tumor of marginal zone cells of native or, more frequently, acquired MALT. The relationship of MALT lymphoma to the normal counterpart population is acknowledged by the revised European-American classification of lymphoid neoplasms (R.E.A.L.). It fits into the extranodal subtype of marginal zone lymphoma listed as a distinct entity in this recent classification scheme. A typical feature of this lymphoma type is a close lymphocyte-epithelium interaction as reflected by lymphoepithelial lesions. The immunophenotype is characterized by the expression of Sig and B-cell-associated antigens and by the lack of CD5 and CD1O. Frequent occurrence of trisomy 3 has been reported.

There is now overwhelming evidence that low-grade MALT lymphomas are subject to immunologic drive. In the stomach, the presence of Helicobacter pylori and locally activated T cells appears to be critical for the growth of neoplastic cells. This finding is of clinical significance since the eradication of H. pylori has been shown to reverse low-grade MALT lymphoma.

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Authors and Affiliations

  1. Institut für Pathologie, Albert Ludwig Universität Freiburg, Albertstr. 19, 79104, Freiburg, Germany

    A. Schmitt-Gräff

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  1. A. Schmitt-Gräff
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Editors and Affiliations

  1. Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Ernst-D. Kreuser

  2. Robert-Rössle Klinik am Max-Delbrück-Centrum, Humboldt-Universität, Lindenberger Weg 80, 13122, Berlin, Germany

    P. M. Schlag

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© 1996 Springer-Verlag Berlin Heidelberg

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Schmitt-Gräff, A. (1996). Immunological and Molecular Classification of Mucosa-Associated Lymphoid Tissue Lymphoma. In: Kreuser, ED., Schlag, P.M. (eds) New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors. Recent Results in Cancer Research, vol 142. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80035-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-80035-1_9

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  • Online ISBN: 978-3-642-80035-1

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