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Studies on the Pathogenesis and Morphogenesis of Glomerulonephrosis

Application of a Newly Developed Morphometric Method

  • Conference paper
Current Topics in Pathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 59))

Abstract

Glomerulonephrosis is defined as a primary non-inflammatory change of the glomerulus referable to a derangement of permeability (dysoria) (Zollinger, 1966 Lit.). It may be differentiated from the various forms of glomerulonephritis by the absence of marked proliferation of local cells. Nor is an increased number of neutrophils, typical of acute diffuse glomerulonephritis, found at any stage of glomerulonephrosis. Another important distinction is that, in contrast to glomerulonephritis, no immune complexes are demonstrable at the peripheral basement membrane in either a linear or granular form. In the various forms of glomerulonephrosis however, immuno-globulins and complement have been found in the mesangium. The part played by these deposits is still obscure. Glomerulonephrosis is characterized by a morphological change involving an increase in the intercellular substance in the mesangium and a mild proliferation of local cells. The first of these is due to the deposition of material which either originates from the capillary blood or is synthesized by the glomerular cells. Plasma components, alien substances or even antigen-antibody complexes may reach the mesangium via the blood stream. Aetiologically the morphological pattern of glomerulonephrosis can be produced by a multiplicity of clinical syndromes and experimental models (Table 1).

Supported by Swiss National Fonds. Dedicated in gratitude to Professor H. U. Zollinger, M.D. on his 60th birthday.

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    E. Grundmann

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    W. H. Kirsten

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Torhorst, J. (1974). Studies on the Pathogenesis and Morphogenesis of Glomerulonephrosis. In: Grundmann, E., Kirsten, W.H. (eds) Current Topics in Pathology. Current Topics in Pathology, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65857-0_1

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