Abstract
Independent of the etiology of the underlying disease the intrapericardial application of drugs offers the advantage that a high local dose can be applied with little systemic side effects. The pericardial sac is, similarly as the pleural space, a nearly ideal compartment for such an application with a very limited exchange of its content to the systemic circulation or other organs.
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Maisch, B., Ristić, A.D., Seferović, P.M., Tsang, T.S.M. (2011). Intrapericardial Treatment in Pericardial Disease. In: Interventional Pericardiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11335-2_10
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