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Anxiety Disorders: From Bench to Bedside and Beyond

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Advances in Psychiatry

Abstract

The anxiety disorders are prevalent, associated with high comorbidity and cause considerable disability. Despite efficacious treatment options, they are frequently misdiagnosed, and management is often suboptimal. With the recent publication of the DSM-5 and the imminent release of the ICD-11, there have been important debates about how best to categorize and conceptualize these disorders. In addition, their underlying neurobiology is being explored at multiple levels from systems neuroscience to molecular biology and genetics—an endeavour that is delivering insights with relevance to clinical practice. Furthermore, several international anxiety disorder treatment guidelines have recently been published, and large systematic reviews and meta-analyses have addressed important questions around clinical management. All of this indicates the need for an update on advances in this rapidly developing field, and this chapter therefore provides an overview of the epidemiology and classification, cognitive-affective neuroscience and clinical management of the anxiety disorders.

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Authors and Affiliations

  1. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa

    Jonathan Starke

  2. Hertfordshire Partnership University NHS Foundation Trust, University of Hertfordshire, University of Cambridge, Cambridge, UK

    Naomi Fineberg

  3. Department of Psychiatry and MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa

    Dan Stein

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  1. Jonathan Starke
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  1. The Medical Centre, Nuneaton, United Kingdom

    Afzal Javed

  2. Division of Neuroscience Medicine, Aristotle University, Division of Neuroscience Medicine, Thessaloniki, Greece

    Kostas N. Fountoulakis

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Starke, J., Fineberg, N., Stein, D. (2019). Anxiety Disorders: From Bench to Bedside and Beyond. In: Javed, A., Fountoulakis, K. (eds) Advances in Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-70554-5_2

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