Abstract
Childhood obsessive-compulsive disorder (OCD) is a heterogeneous psychiatric disorder that affects a sizable amount of youth. Characterized by intrusive obsessions and/or compulsions, OCD has been linked with various deleterious outcomes, such as decreased quality of life and heightened functional impairment. Working with youth with OCD necessitates various considerations, such as level of insight into the symptomology, integrating family into treatment, and degree of symptom accommodation in the family. As such, a holistic understanding of the disorder and its complicating factors are required for the effective treatment of pediatric OCD. Consequently, this chapter aims to review the diagnostic criteria, etiology, symptom presentation, associated clinical characteristics, course and prognosis, and treatment of pediatric OCD.
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References
Abramowitz, J. S. (2013). The practice of exposure therapy: Relevance of cognitive-behavioral theory and extinction theory. Behavior Therapy, 44(4), 548–558.
Abramowitz, J. S., Braddock, A. E., & Moore, E. L. (2009). Psychological treatment of obsessive-compulsive disorder. In M. M. Anthony & M. B. Stein (Eds.), Oxford handbook of anxiety and related disorders. New York: Oxford University Press.
Ahmari, S. E., Spellman, T., Douglass, N. L., Kheirbek, M. A., Simpson, H. B., Deisseroth, K., … Hen, R. (2013). Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science, 340(6137), 1234–1239. doi:10.1126/science.1234733.
American Academy of Child and Adolescent Psychiatry. (2012). Practice parameters for the assessment and treatment of children and adolescents with obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 51(1), 98–113.
American Psychiatric Association [APA]. (1980). Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders, (3rd revised ed.). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th Text Revision ed.). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
Amir, N., Freshman, M., Ramsey, B., Neary, E., & Brigidi, B. (2001). Thought-action fusion in individuals with OCD symptoms. Behaviour Research and Therapy, 39(7), 765–776.
Arch, J. J., & Craske, M. G. (2011). Addressing relapse in cognitive behavioral therapy for panic disorder: Methods for optimizing long-term treatment outcomes. Cognitive and Behavioral Practice, 18(3), 306–315.
Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A., & Kennedy, J. L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Archives of General Psychiatry, 63(7), 769–776. doi:10.1001/archpsyc.63.7.769.
Barr, L. C., Goodman, W. K., Price, L. H., McDougle, C. J., & Charney, D. S. (1992). The serotonin hypothesis of obsessive compulsive disorder: Implications of pharmacologic challenge studies. Journal of Clinical Psychiatry, 53(Suppl), 17–28.
Barrett, P. M., Farrell, L., Dadds, M., & Boulter, N. (2005). Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: Long-term follow-up and predictors of outcome. Journal of the American Academy of Child and Adolescent Psychiatry, 44(10), 1005–1014. doi:10.1097/01.chi.0000172555.26349.94.
Barrett, P. M., Healy-Farrell, L., & March, J. S. (2004). Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: A controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 43(1), 46–62. doi:10.1097/01.chi.0000096367.43887.13.
Bloch, M. H., Craiglow, B. G., Landeros-Weisenberger, A., Dombrowski, P. A., Panza, K. E., Peterson, B. S., & Leckman, J. F. (2009). Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder. Pediatrics, 124(4), 1085–1093.
Bloch, M. H., Landeros-Weisenberger, A., Rosario, M. C., Pittenger, C., & Leckman, J. F. (2008). Meta-analysis of the symptom structure of obsessive-compulsive disorder. American Journal of Psychiatry, 165(12), 1532–1542. doi:10.1176/appi.ajp.2008.08020320.
Boileau, B. (2011). A review of obsessive-compulsive disorder in children and adolescents. Dialogues in Clinical Neuroscience, 13(4), 401–411.
Bora, E., Harrison, B. J., Fornito, A., Cocchi, L., Pujol, J., Fontenelle, L. F., … Yucel, M. (2011). White matter microstructure in patients with obsessive-compulsive disorder. Journal of Psychiatry and Neuroscience, 36(1), 42–46. doi:10.1503/jpn.100082.
Brambilla, P., Barale, F., Caverzasi, E., & Soares, J. C. (2002). Anatomical MRI findings in mood and anxiety disorders. Epidemiologia e Psichiatria Sociale, 11(2), 88–99.
Calvocoressi, L., Lewis, B., Harris, M., Trufan, S. J., Goodman, W. K., McDougle, C. J., & Price, L. H. (1995). Family accommodation in obsessive-compulsive disorder. The American Journal of Psychiatry, 152, 441–443.
Calvocoressi, L., Mazure, C. M., Kasl, S. V., Skolnick, J., Fisk, D., Vegso, S. J., … Price, L. H. (1999). Family accommodation of obsessive-compulsive symptoms: Instrument development and assessment of family behavior. Journal of Nervous and Mental Disease, 187(10), 636–642.
Caporino, N. E., Morgan, J., Beckstead, J., Phares, V., Murphy, T. K., & Storch, E. A. (2012). A structural equation analysis of family accommodation in pediatric obsessive-compulsive disorder. Journal of Abnormal Child Psychology, 40(1), 133–143. doi:10.1007/s10802-011-9549-8.
Cavedini, P., Riboldi, G., D'Annucci, A., Belotti, P., Cisima, M., & Bellodi, L. (2002). Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia, 40(2), 205–211.
Comer, J. S., Furr, J. M., Cooper-Vince, C. E., Kerns, C. E., Chan, P. T., Edson, A. L., … Freeman, J. B. (2014). Internet-delivered, family-based treatment for early-onset OCD: A preliminary case series. Journal of Clinical Child & Adolescent Psychology, 43(1), 74–87.
Davis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., … Scharf, J. M. (2013). Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genetics, 9(10), e1003864. doi:10.1371/journal.pgen.1003864.
de Mathis, M. A., do Rosario, M. C., Diniz, J. B., Torres, A. R., Shavitt, R. G., Ferrao, Y. A., … Miguel, E. C. (2008). Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry, 23(3), 187–194. doi:10.1016/j.eurpsy.2008.01.002.
DuPaul, G. J., Eckert, T. L., & Vilardo, B. (2012). The effects of school-based interventions for attention deficit hyperactivity disorder: A meta-analysis 1996-2010. School Psychology Review, 41(4), 387–412.
Farrell, L. J., Waters, A. M., Boschen, M. J., Hattingh, L., McConnell, H., Milliner, E. L., … Storch, E. A. (2013). Difficult-to-treat pediatric obsessive-compulsive disorder: Feasibility and preliminary results of a randomized pilot trial of D-cycloserine-augmented behavior therapy. Depression and Anxiety, 30(8), 723–731. doi:10.1002/da.22132.
Flament, M. F., Koby, E., Rapoport, J. L., Berg, C. J., Zahn, T., Cox, C., … Lenane, M. (1990). Childhood obsessive-compulsive disorder: A prospective follow-up study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 31(3), 363–380.
Flessner, C. A., Freeman, J. B., Sapyta, J., Garcia, A., Franklin, M. E., March, J. S., & Foa, E. (2011). Predictors of parental accommodation in pediatric obsessive-compulsive disorder: Findings from the pediatric obsessive-compulsive disorder treatment study (POTS) trial. Journal of the American Academy of Child and Adolescent Psychiatry, 50(7), 716–725. doi:10.1016/j.jaac.2011.03.019.
Franklin, M. E., Sapyta, J., Freeman, J. B., Khanna, M., Compton, S., Almirall, D., … March, J. S. (2011). Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: The pediatric OCD treatment study II (POTS II) randomized controlled trial. Journal of the American Medical Association, 306(11), 1224–1232.
Freeman, J., Garcia, A., Benito, K., Conelea, C., Sapyta, J., Khanna, M., … Franklin, M. (2012). The pediatric obsessive compulsive disorder treatment study for young children (POTS jr): Developmental considerations in the rationale, design, and methods. Journal of Obsessive-Compulsive and Related Disorders, 1(4), 294–300. doi:10.1016/j.jocrd.2012.07.010.
Freeman, J., Sapyta, J., Garcia, A., Compton, S., Khanna, M., Flessner, C., … Franklin, M. (2014). Family-based treatment of early childhood obsessive-compulsive disorder: The pediatric obsessive-compulsive disorder treatment study for young children (POTS Jr)--a randomized clinical trial. JAMA Psychiatry, 71(6), 689–698. doi:10.1001/jamapsychiatry.2014.170.
Frost, R., & Steketee, G. (Eds.). (2002). Cognitive approaches to obsessions and compulsions: Theory, assessment, and treatment. Oxford, UK: Elsevier.
Garcia, A. M., Freeman, J. B., Himle, M. B., Berman, N. C., Ogata, A. K., Ng, J., … Leonard, H. (2009). Phenomenology of early childhood onset obsessive compulsive disorder. Journal of Psychopathology and Behavioral Assessment, 31(2), 104–111. doi:10.1007/s10862-008-9094-0.
Garibotto, V., Scifo, P., Gorini, A., Alonso, C. R., Brambati, S., Bellodi, L., & Perani, D. (2010). Disorganization of anatomical connectivity in obsessive compulsive disorder: A multi-parameter diffusion tensor imaging study in a subpopulation of patients. Neurobiology of Disease, 37(2), 468–476. doi:10.1016/j.nbd.2009.11.003.
Geller, D. A. (2006). Obsessive-compulsive and spectrum disorders in children and adolescents. The Psychiatric Clinics of North America, 29(2), 353–370. doi:10.1016/j.psc.2006.02.012.
Geller, D. A., Biederman, J., Faraone, S. V., Cradock, K., Hagermoser, L., Zaman, N., … Spencer, T. J. (2002). Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: Fact or artifact? Journal of the American Academy of Child and Adolescent Psychiatry, 41, 52–58.
Geller, D. A., Biederman, J., Faraone, S., Agranat, A., Cradock, K., Hagermoser, L., … Coffey, B. J. (2001a). Developmental aspects of obsessive compulsive disorder: Findings in children, adolescents, and adults. Journal of Nervous and Mental Disease, 189(7), 471–477.
Geller, D. A., Biederman, J., Faraone, S., Spencer, T., Doyle, R., Mullin, B., … Farrell, C. (2004). Re-examining comorbidity of obsessive compulsive and attention-deficit hyperactivity disorder using an empirically derived taxonomy. European Child & Adolescent Psychiatry, 13(2), 83–91. doi:10.1007/s00787-004-0379-x.
Geller, D. A., Biederman, J., Faraone, S. V., Bellordre, C. A., Kim, G. S., Hagermoser, L., … Coffey, B. J. (2001b). Disentangling chronological age from age of onset in children and adolescents with obsessive--compulsive disorder. International Journal of Neuropsychopharmacology, 4(2), 169–178. doi:10.1017/S1461145701002395.
Geller, D. A., Biederman, J., Griffin, S., Jones, J., & Lefkowitz, T. R. (1996). Comorbidity of juvenile obsessive-compulsive disorder with disruptive behavior disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 35(12), 1637–1646. doi:10.1097/00004583-199612000-00016.
Geller, D. A., Biederman, J., Stewart, S. E., Mullin, B., Farrell, C., Wagner, K. D., … Carpenter, D. (2003a). Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: Is the use of exclusion criteria empirically supported in randomized clinical trials? Journal of Child and Adolescent Psychopharmacology, 13(Suppl 1), S19–S29. doi:10.1089/104454603322126313.
Geller, D. A., Biederman, J., Stewart, S. E., Mullin, B., Martin, A., Spencer, T., & Faraone, S. V. (2003b). Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder. American Journal of Psychiatry, 160(11), 1919–1928.
Ginsburg, G. S., Kingery, J. N., Drake, K. L., & Grados, M. A. (2008). Predictors of treatment response in pediatric obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 868–878. doi:10.1097/CHI.0b013e3181799ebd.
Goodman, W. K., McDougle, C. J., Price, L. H., Riddle, M. A., Pauls, D. L., & Leckman, J. F. (1990). Beyond the serotonin hypothesis: A role for dopamine in some forms of obsessive compulsive disorder? Journal of Clinical Psychiatry, 51(Suppl), 36–43; discussion 55–38.
Grados, M. A., Walkup, J., & Walford, S. (2003). Genetics of obsessive-compulsive disorders: New findings and challenges. Brain and Development, 25(Suppl 1), S55–S61.
Greisberg, S., & McKay, D. (2003). Neuropsychology of obsessive-compulsive disorder: A review and treatment implications. Clinical Psychology Review, 23(1), 95–117. doi: http://dx.doi.org/10.1016/S0272-7358(02)00232-5.
Gruner, P., Vo, A., Ikuta, T., Mahon, K., Peters, B. D., Malhotra, A. K., … Szeszko, P. R. (2012). White matter abnormalities in pediatric obsessive-compulsive disorder. Neuropsychopharmacology, 37(12), 2730–2739. doi:10.1038/npp.2012.138.
Hall, D., Dhilla, A., Charalambous, A., Gogos, J. A., & Karayiorgou, M. (2003). Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. American Journal of Human Genetics, 73(2), 370–376. doi:10.1086/377003.
Hemmings, S. M., Kinnear, C. J., Lochner, C., Niehaus, D. J., Knowles, J. A., Moolman-Smook, J. C., … Stein, D. J. (2004). Early- versus late-onset obsessive-compulsive disorder: Investigating genetic and clinical correlates. Psychiatry Research, 128(2), 175–182. doi:10.1016/j.psychres.2004.05.007.
Hollander, E., Braun, A., & Simeon, D. (2008). Should OCD leave the anxiety disorders in DSM-V? The case for obsessive compulsive-related disorders. Depression and Anxiety, 25(4), 317–329. doi:10.1002/da.20500.
Hopko, D. R., Lejuez, C. W., Ruggiero, K. J., & Eifert, G. H. (2003). Contemporary behavioral activation treatments for depression: Procedures, principles, and progress. Clinical Psychology Review, 23(5), 699–717.
Hu, X. Z., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., … Goldman, D. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78(5), 815–826. doi:10.1086/503850.
Insel, T. R. (1992). Toward a neuroanatomy of obsessive-compulsive disorder. Archives of General Psychiatry, 49(9), 739–744.
Ivarsson, T., Melin, K., & Wallin, L. (2008). Categorical and dimensional aspects of co-morbidity in obsessive-compulsive disorder (OCD). European Child & Adolescent Psychiatry, 17(1), 20–31. doi:10.1007/s00787-007-0626-z.
Janowitz, D., Grabe, H. J., Ruhrmann, S., Ettelt, S., Buhtz, F., Hochrein, A., … Wagner, M. (2009). Early onset of obsessive-compulsive disorder and associated comorbidity. Depression and Anxiety, 26(11), 1012–1017. doi:10.1002/da.20597.
Karayiorgou, M., Sobin, C., Blundell, M. L., Galke, B. L., Malinova, L., Goldberg, P., … Gogos, J. A. (1999). Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biological Psychiatry, 45(9), 1178–1189.
Katerberg, H., Delucchi, K. L., Stewart, S. E., Lochner, C., Denys, D. A., Stack, D. E., … Cath, D. C. (2010). Symptom dimensions in OCD: Item-level factor analysis and heritability estimates. Behavior Genetics, 40(4), 505–517. doi:10.1007/s10519-010-9339-z.
Kendall, P. C., Robin, J. A., Hedtke, K. A., Suveg, C., Flannery-Schroeder, E., & Gosch, E. (2006). Considering CBT with anxious youth? Think exposures. Cognitive and Behavioral Practice, 12(1), 136–148.
Kircanski, K., Peris, T. S., & Piacentini, J. C. (2011). Cognitive-behavioral therapy for obsessive-compulsive disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 20(2), 239–254. doi:10.1016/j.chc.2011.01.014.
Kushner, M. G., Kim, S. W., Donahue, C., Thuras, P., Adson, D., Kotlyar, M., … Foa, E. B. (2007). D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biological Psychiatry, 62(8), 835–838. doi:10.1016/j.biopsych.2006.12.020.
Lacerda, A. L., Dalgalarrondo, P., Caetano, D., Camargo, E. E., Etchebehere, E. C., & Soares, J. C. (2003). Elevated thalamic and prefrontal regional cerebral blood flow in obsessive-compulsive disorder: A SPECT study. Psychiatry Research, 123(2), 125–134.
Lack, C. W., Storch, E. A., Keeley, M. L., Geffken, G. R., Ricketts, E. D., Murphy, T. K., & Goodman, W. K. (2009). Quality of life in children and adolescents with obsessive-compulsive disorder: Base rates, parent-child agreement, and clinical correlates. Social Psychiatry and Psychiatric Epidemiology, 44(11), 935–942. doi:10.1007/s00127-009-0013-9.
Leckman, J. F., Denys, D., Simpson, H. B., Mataix-Cols, D., Hollander, E., Saxena, S., … Stein, D. J. (2010). Obsessive-compulsive disorder: A review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V. Depression and Anxiety, 27(6), 507–527. doi:10.1002/da.20669.
Lewin, A. B., Park, J. M., Jones, A. M., Crawford, E. A., DeNadai, A. S., Menzel, J., … Storch, E. A. (2014a). Family-based exposure and response prevention therapy for preschool-aged children with obsessive-compulsive disorder: A pilot randomized controlled trial. Behaviour Research and Therapy, 56, 30–38.
Lewin, A. B., Peris, T. S., Lindsey Bergman, R., McCracken, J. T., & Piacentini, J. (2011). The role of treatment expectancy in youth receiving exposure-based CBT for obsessive compulsive disorder. Behaviour Research and Therapy, 49(9), 536–543. doi:10.1016/j.brat.2011.06.001.
Lewin, A. B., & Piacentini, J. (2009). Obsessive-compulsive disorder in children. In B. J. Sadock, V. A. Sadock, & P. Ruiz (Eds.), Kaplan & Sadock’s comprehensive textbook of psychiatry (vol. 2, 9th ed.pp. 3671–3678). Philadelphia: Lippincott Williams & Wilkins.
Lewin, A. B., Wu, M. S., McGuire, J. F., & Storch, E. A. (2014b). Cognitive behavior therapy for obsessive-compulsive and related disorders. Psychiatric Clinics of North America, 37(3), 415–445. doi:10.1016/j.psc.2014.05.002.
Lin, P. Y. (2007). Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31(3), 683–689. doi:10.1016/j.pnpbp.2006.12.024.
March, J. S., Franklin, M. E., Leonard, H., Garcia, A., Moore, P., Freeman, J., & Foa, E. (2007). Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder. Biological Psychiatry, 61(3), 344–347. doi:10.1016/j.biopsych.2006.09.035.
March, J. S., & Leonard, H. L. (1996). Obsessive-compulsive disorder in children and adolescents: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry, 35(10), 1265–1273. doi:10.1097/00004583-199610000-00012.
Martin, A., Young, C., Leckman, J. F., Mukonoweshuro, C., Rosenheck, R., & Leslie, D. (2004). Age effects on antidepressant-induced manic conversion. Archives of Pediatrics and Adolescent Medicine, 158(8), 773–780. doi:10.1001/archpedi.158.8.773.
Masi, G., Millepiedi, S., Mucci, M., Bertini, N., Pfanner, C., & Arcangeli, F. (2006). Comorbidity of obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Comprehensive Psychiatry, 47(1), 42–47. doi:10.1016/j.comppsych.2005.04.008.
Mataix-Cols, D., Pertusa, A., & Leckman, J. F. (2007). Issues for DSM-V: How should obsessive-compulsive and related disorders be classified? American Journal of Psychiatry, 164(9), 1313–1314. doi:10.1176/appi.ajp.2007.07040568.
Mataix-Cols, D., Rauch, S. L., Manzo, P. A., Jenike, M. A., & Baer, L. (1999). Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. American Journal of Psychiatry, 156(9), 1409–1416.
Mataix-Cols, D., Turner, C., Monzani, B., Isomura, K., Murphy, C., Krebs, G., & Heyman, I. (2014). Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial. British Journal of Psychiatry, 204(1), 77–78. doi:10.1192/bjp.bp.113.126284.
Mattheisen, M., Samuels, J. F., Wang, Y., Greenberg, B. D., Fyer, A. J., McCracken, J. T., … Nestadt, G. (2014). Genome-wide association study in obsessive-compulsive disorder: Results from the OCGAS. Molecular Psychiatry. doi:10.1038/mp.2014.43.
McDougle, C. J., Epperson, C. N., Price, L. H., & Gelernter, J. (1998). Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Molecular Psychiatry, 3(3), 270–273.
McGuire, J. F., Lewin, A. B., & Storch, E. A. (2014). Enhancing exposure therapy for anxiety disorders, obsessive-compulsive disorder and post-traumatic stress disorder. Expert Review of Neurotherapeutics, 14(8), 893–910. doi:10.1586/14737175.2014.934677.
McGuire, J. F., Wu, M. S., Piacentini, J., McCracken, J. T., & Storch, E. A. (2017). A meta-analysis of dcycloserine in exposure-based treatment: Moderators of treatment efficacy, response, and diagnostic remission. Journal of clinical Psychiatry, 78(2), 196–206.
Micali, N., Heyman, I., Perez, M., Hilton, K., Nakatani, E., Turner, C., & Mataix-Cols, D. (2010). Long-term outcomes of obsessive-compulsive disorder: Follow-up of 142 children and adolescents. The British Journal of Psychiatry, 197(2), 128–134. doi:10.1192/bjp.bp.109.075317.
Michael, K. D., & Crowley, S. L. (2002). How effective are treatments for child and adolescent depression? A meta-analytic review. Clinical Psychology Review, 22(2), 247–269. doi: http://dx.doi.org/10.1016/S0272-7358(01)00089-7.
Millet, B., Kochman, F., Gallarda, T., Krebs, M. O., Demonfaucon, F., Barrot, I., … Hantouche, E. G. (2004). Phenomenological and comorbid features associated in obsessive-compulsive disorder: Influence of age of onset. Journal of Affective Disorders, 79(1–3), 241–246. doi:10.1016/s0165-0327(02)00351-8.
Modell, J. G., Mountz, J. M., Curtis, G. C., & Greden, J. F. (1989). Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 1(1), 27–36.
Mundo, E., Richter, M. A., Zai, G., Sam, F., McBride, J., Macciardi, F., & Kennedy, J. L. (2002). 5HT1Dbeta receptor gene implicated in the pathogenesis of obsessive-compulsive disorder: Further evidence from a family-based association study. Molecular Psychiatry, 7(7), 805–809. doi:10.1038/sj.mp.4001059.
Murphy, T. K., Kurlan, R., & Leckman, J. (2010). The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, and related disorders: A way forward. Journal of Child and Adolescent Psychopharmacology, 20(4), 317–331. doi:10.1089/cap.2010.0043.
Murphy, T. K., Petitto, J. M., Voeller, K. K., & Goodman, W. K. (2001). Obsessive compulsive disorder: Is there an association with childhood streptococcal infections and altered immune function? Seminars in Clinical Neuropsychiatry, 6(4), 266–276.
Murphy, T. K., Segarra, A., Storch, E. A., & Goodman, W. K. (2008). SSRI adverse events: How to monitor and manage. International Review of Psychiatry, 20(2), 203–208. doi:10.1080/09540260801889211.
Nadeau, J. M., Lewin, A. B., Arnold, E. B., Crawford, E. A., Murphy, T. K., & Storch, E. A. (2013). Clinical correlates of functional impairment in children and adolescents with obsessive–compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders, 2(4), 432–436.
National Collaborating Centre for Mental Health (NCCMH). (2006). Obsessive-compulsive disorder: Core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder. Leicester, UK/London: The British Psychological Society and The Royal College of Psychiatrists.
Nestadt, G., Samuels, J., Riddle, M., Bienvenu 3rd, O. J., Liang, K. Y., LaBuda, M., … Hoehn-Saric, R. (2000). A family study of obsessive-compulsive disorder. Archives of General Psychiatry, 57(4), 358–363.
O’Neill, J., Piacentini, J. C., Chang, S., Levitt, J. G., Rozenman, M., Bergman, L., … McCracken, J. T. (2012). MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 36(1), 161–168. doi:10.1016/j.pnpbp.2011.09.007.
Palermo, S. D., Bloch, M. H., Craiglow, B., Landeros-Weisenberger, A., Dombrowski, P. A., Panza, K., … Leckman, J. F. (2011). Predictors of early adulthood quality of life in children with obsessive-compulsive disorder. Social Psychiatry and Psychiatric Epidemiology, 46(4), 291–297. doi:10.1007/s00127-010-0194-2.
Peris, T. S., Bergman, R. L., Langley, A., Chang, S., McCracken, J. T., & Piacentini, J. (2008). Correlates of accommodation of pediatric obsessive-compulsive disorder: Parent, child, and family characteristics. Journal of the American Academy of Child and Adolescent Psychiatry, 47(10), 1173–1181. doi:10.1097/CHI.0b013e3181825a91.
Phillips, K. A., Stein, D. J., Rauch, S. L., Hollander, E., Fallon, B. A., Barsky, A., … Leckman, J. (2010). Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V? Depression and Anxiety, 27(6), 528–555. doi:10.1002/da.20705.
Piacentini, J., & Bergman, R. L. (2001). Developmental issues in cognitive therapy for childhood anxiety disorders. Journal of Cognitive Psychotherapy, 15(3), 165–182.
Piacentini, J., Bergman, R. L., Chang, S., Langley, A., Peris, T. S., Wood, J. J., & McCracken, J. (2011). Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 50(11), 1149–1161.
Piacentini, J., Bergman, R. L., Keller, M., & McCracken, J. (2003). Functional impairment in children and adolescents with obsessive-compulsive disorder. Journal of Child and Adolescent Psychopharmacology, 13, S61–S69. doi:10.1089/104454603322126359.
Piacentini, J., Langley, A., & Roblek, T. (2007a). Cognitive-behavioral treatment of childhood OCD: it's only a false alarm. New York: Oxford University Press.
Piacentini, J., Peris, T. S., Bergman, R. L., Chang, S., & Jaffer, M. (2007b). Functional impairment in childhood OCD: Development and psychometrics properties of the child obsessive-compulsive impact scale-revised (COIS-R). Journal of Clinical Child and Adolescent Psychology, 36(4), 645–653. doi:10.1080/15374410701662790.
Pittenger, C., Bloch, M. H., & Williams, K. (2011). Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment. Pharmacology & Therapeutics, 132(3), 314–332. doi:10.1016/j.pharmthera.2011.09.006.
Rauch, S. L., & Savage, C. R. (1997). Neuroimaging and neuropsychology of the striatum. Bridging basic science and clinical practice. Psychiatric Clinics of North America, 20(4), 741–768.
Rettew, D. C., Swedo, S. E., Leonard, H. L., Lenane, M. C., & Rapoport, J. L. (1992). Obsessions and compulsions across time in 79 children and adolescents with obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31(6), 1050–1056. doi:10.1097/00004583-199211000-00009.
Robinson, D., Wu, H., Munne, R. A., Ashtari, M., Alvir, J. M., Lerner, G., … Bogerts, B. (1995). Reduced caudate nucleus volume in obsessive-compulsive disorder. Archives of General Psychiatry, 52(5), 393–398.
Ruiz, F. J. (2012). Acceptance and commitment therapy versus traditional cognitive behavioral therapy: A systematic review and meta-analysis of current empirical evidence. International Journal of Psychology and Psychological Therapy, 12(2), 333–357.
Sampaio, A. S., Fagerness, J., Crane, J., Leboyer, M., Delorme, R., Pauls, D. L., & Stewart, S. E. (2011). Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: A family-based study. CNS Neuroscience & Therapeutics, 17(3), 141–147. doi:10.1111/j.1755-5949.2009.00130.x.
Scarone, S., Colombo, C., Livian, S., Abbruzzese, M., Ronchi, P., Locatelli, M., … Smeraldi, E. (1992). Increased right caudate nucleus size in obsessive-compulsive disorder: Detection with magnetic resonance imaging. Psychiatry Research, 45(2), 115–121.
Selles, R. R., Storch, E. A., & Lewin, A. B. (2014). Variations in symptom prevalence and clinical correlates in younger versus older youth with obsessive-compulsive disorder. Child Psychiatry and Human Development. doi:10.1007/s10578-014-0435-9.
Shafran, R., & Rachman, S. (2004). Thought-action fusion: A review. Journal of Behavior Therapy and Experimental Psychiatry, 35(2), 87–107.
Simpson, H. B., Maher, M. J., Wang, Y., Bao, Y., Foa, E. B., & Franklin, M. (2011). Patient adherence predicts outcome from cognitive behavioral therapy in obsessive-compulsive disorder. Journal of Consulting and Clinical Psychology, 79(2), 247–252. doi:10.1037/a0022659.
Simpson, H. B., Marcus, S. M., Zuckoff, A., Franklin, M., & Foa, E. B. (2012). Patient adherence to cognitive-behavioral therapy predicts long-term outcome in obsessive-compulsive disorder. Journal of Clinical Psychiatry, 73(9), 1265–1266. doi:10.4088/JCP.12l07879.
Stein, D. J., Andersen, E. W., & Overo, K. F. (2007). Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo. Revista Brasileira de Psiquiatria, 29(4), 303–307. doi: S1516-44462007000400003 [pii].
Stein, D. J., Fineberg, N. A., Bienvenu, O. J., Denys, D., Lochner, C., Nestadt, G., … Phillips, K. A. (2010). Should OCD be classified as an anxiety disorder in DSM-V? Depression and Anxiety, 27(6), 495–506. doi:10.1002/da.20699.
Stewart, S. E., Fagerness, J. A., Platko, J., Smoller, J. W., Scharf, J. M., Illmann, C., … Pauls, D. L. (2007a). Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B(8), 1027–1033. doi:10.1002/ajmg.b.30533.
Stewart, S. E., Geller, D. A., Jenike, M., Pauls, D., Shaw, D., Mullin, B., & Faraone, S. V. (2004). Long-term outcome of pediatric obsessive-compulsive disorder: A meta-analysis and qualitative review of the literature. Acta Psychiatrica Scandinavica, 110(1), 4–13. doi:10.1111/j.1600-0447.2004.00302.x.
Stewart, S. E., Mayerfeld, C., Arnold, P. D., Crane, J. R., O'Dushlaine, C., Fagerness, J. A., … Mathews, C. A. (2013a). Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, 162B(4), 367–379. doi:10.1002/ajmg.b.32137.
Stewart, S. E., Rosario, M. C., Brown, T. A., Carter, A. S., Leckman, J. F., Sukhodolsky, D., … Pauls, D. L. (2007b). Principal components analysis of obsessive-compulsive disorder symptoms in children and adolescents. Biological Psychiatry, 61(3), 285–291. doi: S0006-3223(06)01111-5 [pii]. doi:10.1016/j.biopsych.2006.08.040.
Stewart, S. E., Yu, D., Scharf, J. M., Neale, B. M., Fagerness, J. A., Mathews, C. A., … Pauls, D. L. (2013b). Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry, 18(7), 788–798. doi:10.1038/mp.2012.85.
Storch, E. A., Abramowitz, J., & Goodman, W. K. (2008a). Where does obsessive-compulsive disorder belong in DSM-V? Depression and Anxiety, 25(4), 336–347. doi:10.1002/da.20488.
Storch, E. A., Björgvinsson, T., Riemann, B., Lewin, A. B., Morales, M. J., & Murphy, T. K. (2010a). Factors associated with poor response in cognitive-behavioral therapy for pediatric obsessive-compulsive disorder. Bulletin of the Menninger Clinic, 74(2), 167–185.
Storch, E. A., Caporino, N. E., Morgan, J. R., Lewin, A. B., Rojas, A., Brauer, L., … Murphy, T. K. (2011). Preliminary investigation of web-camera delivered cognitive-behavioral therapy for youth with obsessive-compulsive disorder. Psychiatry Research, 189(3), 407–412. doi:10.1016/j.psychres.2011.05.047.
Storch, E. A., Geffken, G. R., Merlo, L. J., Jacob, M. L., Murphy, T. K., Goodman, W. K., … Grabill, K. (2007a). Family accommodation in pediatric obsessive-compulsive disorder. Journal of Clinical Child and Adolescent Psychology, 36(2), 207–216. doi:10.1080/15374410701277929.
Storch, E. A., Geffken, G. R., Merlo, L. J., Mann, G., Duke, D., Munson, M., … Goodman, W. K. (2007b). Family-based cognitive-behavioral therapy for pediatric obsessive-compulsive disorder: Comparison of intensive and weekly approaches. Journal of the American Academy of Child and Adolescent Psychiatry, 46(4), 469–478. doi:10.1097/chi.0b013e31803062e7.
Storch, E. A., Larson, M. J., Muroff, J., Caporino, N., Geller, D., Reid, J. M., … Murphy, T. K. (2010b). Predictors of functional impairment in pediatric obsessive-compulsive disorder. Journal of Anxiety Disorders, 24(2), 275–283. doi:10.1016/j.janxdis.2009.12.004.
Storch, E. A., Lewin, A. B., Geffken, G. R., Morgan, J. R., & Murphy, T. K. (2010c). The role of comorbid disruptive behavior in the clinical expression of pediatric obsessive-compulsive disorder. Behaviour Research and Therapy, 48(12), 1204–1210. doi:10.1016/j.brat.2010.09.004.
Storch, E. A., Merlo, L. J., Larson, M. J., Geffken, G. R., Lehmkuhl, H. D., Jacob, M. L., … Goodman, W. K. (2008b). Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47(5), 583–592. doi:10.1097/CHI.0b013e31816774b1.
Storch, E. A., Murphy, T. K., Goodman, W. K., Geffken, G. R., Lewin, A. B., Henin, A., … Geller, D. A. (2010d). A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biological Psychiatry, 68(11), 1073–1076. doi:10.1016/j.biopsych.2010.07.015.
Storch, E. A., Rudy, B., Wu, M. S., Lewin, A. B., & Murphy, T. K. (2014). Moderators of impairment agreement among parent-child dyads in pediatric obsessive-compulsive disorder. Journal of Psychopathology and Behavioral Assessment. doi:10.1007/s10862-014-9456-8.
Storch, E. A., Wilhelm, S., Sprich, S., Henin, A., Micco, J., Small, B. J., … Geller, D. A. (2016). Efficacy of Augmentation of Cognitive Behavior Therapy With Weight-Adjusted d-Cycloserine vs Placebo in Pediatric Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry, 73(8), 779–788.
Swedo, S. E., Leckman, J. F., & Rose, N. R. (2012). From research subgroup to clinical syndrome: Modifying the PANDAS criteria to describe PANS (pediatric acute-onset neuropsychiatric syndrome). Pediatrics & Therapeutics, 2. doi: http://dx.doi.org/10.4172/2161-0665.1000113.
Swedo, S. E., Leonard, H. L., Garvey, M., Mittleman, B., Allen, A. J., Perlmutter, S., … Dubbert, B. K. (1998). Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. American Journal of Psychiatry, 155(2), 264–271.
The Pediatric OCD Treatment Study (POTS) Team. (2004). Cognitive-behavior therapy, sertraline, and their combination with children and adolescents with obsessive-compulsive disorder: The pediatric OCD treatment study (POTS) randomized controlled trial. Journal of the American Medical Association, 292(16), 1969–1976.
Thompson-Hollands, J., Edson, A., Tompson, M. C., & Comer, J. S. (2014). Family involvement in the psychological treatment of obsessive-compulsive disorder: A meta-analysis. Journal of Family Psychology, 28(3), 287–298. doi:10.1037/a0036709.
Thoren, P., Asberg, M., Bertilsson, L., Mellstrom, B., Sjoqvist, F., & Traskman, L. (1980). Clomipramine treatment of obsessive-compulsive disorder. II. Biochemical aspects. Archives of General Psychiatry, 37(11), 1289–1294.
Ting, J. T., & Feng, G. (2008). Glutamatergic synaptic dysfunction and obsessive-compulsive disorder. Current Chemical Genomics, 2, 62–75. doi:10.2174/1875397300802010062.
Tukel, R., Ertekin, E., Batmaz, S., Alyanak, F., Sozen, A., Aslantas, B., … Ozyildirim, I. (2005). Influence of age of onset on clinical features in obsessive-compulsive disorder. Depression and Anxiety, 21(3), 112–117. doi:10.1002/da.20065.
Twohig, M. P., Hayes, S. C., & Masuda, A. (2006). Increasing willingness to experience obsessions: Acceptance and commitment therapy as a treatment for obsessive-compulsive disorder. Behavior Therapy, 37(1), 3–13. doi: http://dx.doi.org/10.1016/j.beth.2005.02.001.
Valderhaug, R., & Ivarsson, T. (2005). Functional impairment in clinical samples of Norwegian and Swedish children and adolescents with obsessive-compulsive disorder. European Child & Adolescent Psychiatry, 14(3), 164–173. doi:10.1007/s00787-005-0456-9.
Van der Oord, S., Prins, P. J. M., Oosterlaan, J., & Emmelkamp, P. M. G. (2008). Efficacy of methylphenidate, psychosocial treatments and their combination in school-aged children with ADHD: A meta-analysis. Clinical Psychology Review, 28(5), 783–800.
van Grootheest, D. S., Cath, D. C., Beekman, A. T., & Boomsma, D. I. (2005). Twin studies on obsessive-compulsive disorder: A review. Twin Research and Human Genetics, 8(5), 450–458. doi:10.1375/183242705774310060.
Watson, H. J., & Rees, C. S. (2008). Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49(5), 489–498. doi:10.1111/j.1469-7610.2007.01875.x.
Wilhelm, S., Buhlmann, U., Tolin, D. F., Meunier, S. A., Pearlson, G. D., Reese, H. E., … Rauch, S. L. (2008). Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder. American Journal of Psychiatry, 165(3), 335–341; quiz 409. doi:10.1176/appi.ajp.2007.07050776.
Wu, K., Hanna, G. L., Rosenberg, D. R., & Arnold, P. D. (2012). The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacology, Biochemistry, and Behavior, 100(4), 726–735. doi:10.1016/j.pbb.2011.10.007.
Wu, M. S., & Lewin, A. B. (in press). Insight in obsessive-complsive disorder. In D. McKay, E. A. Storch, & J. S. Abramowitz (Eds.), Handbook of obsessive-compulsive disorder across the lifespan. Wiley.
Wu, M. S., Lewin, A. B., Murphy, T. K., Geffken, G. R., & Storch, E. A. (2014). Phenomenological considerations of family accommodation: Related clinical characteristics and family factors in pediatric OCD. Journal of Obsessive-Compulsive and Related Disorders, 3(3), 228–235.
Zohar, A. H. (1999). The epidemiology of obsessive-compulsive disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 8(3), 445–460.
Zohar, J., & Insel, T. R. (1987). Obsessive-compulsive disorder: Psychobiological approaches to diagnosis, treatment, and pathophysiology. Biological Psychiatry, 22(6), 667–687.
Zuchner, S., Wendland, J. R., Ashley-Koch, A. E., Collins, A. L., Tran-Viet, K. N., Quinn, K., … Murphy, D. L. (2009). Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Molecular Psychiatry, 14(1), 6–9. doi:10.1038/mp.2008.83.
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Wu, M.S., Selles, R.R., Storch, E.A. (2017). Obsessive-Compulsive Disorder. In: Goldstein, S., DeVries, M. (eds) Handbook of DSM-5 Disorders in Children and Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-319-57196-6_10
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