Abstract
Lesbian, gay, bisexual, and transgender (LGBT) individuals experience chronic stress, or “minority stress,” that increases the risk of developing poor psychological, physical, and behavioral health outcomes. In addition to demonstrating the multifaceted impact of minority stress on health, recent research has outlined underlying psychological mechanisms by which stigma-related stressors are associated with negative health outcomes. To date, however, little is known about these underlying physiological mechanisms or how stress biomarkers may function clinically to mediate/moderate the relationship between stigma and health outcomes among LGBT individuals. One biomarker, the stress hormone cortisol, is believed to play an important role in the experience of minority stress. When individuals experience chronic stress, as in the experience of minority stress, cortisol exerts significant strain on multiple biological systems known as allostatic load. This chapter aims to provide healthcare providers with an understanding of allostatic load and the mechanisms underlying its impact on interconnected biological systems in the context of a growing body of research addressing the psychological and behavioral effects of minority stress experienced by LGBT individuals. Also outlined are implications for public policy reform and community advocacy, as well as strategies healthcare providers can use to help LGBT clients manage the effects of minority stress and foster resilience.
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References
IOM. The health of lesbian, gay, bisexual, and transgender people: building a foundation for better understanding. Washington, DC: The National Academies Press; 2011.
Beauchamp D. Sexual orientation and victimization, 2004. In: Statistics CCfJ, editor. . Ottawa: Statistics Canada. p. 2004.
Mays VM, Cochran SD. Mental health correlates of perceived discrimination among lesbian, gay, and bisexual adults in the United States. Am J Public Health. 2001;91(11):1869–76.
National Coalition of Anti-Violence Programs. 2013 report on lesbian, gay, bisexual, transgender, queen and HIV-affected hate violence. 2014. Accessed 6 April 2017. Available at: http://www.avp.org/storage/documents/2013_ncavp_hvreport_final.pdf.
Meyer IH. Minority stress and mental health in gay men. J Health Soc Behav. 1995;36(1):38–56.
Meyer IH. Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Psychol Bull. 2003;129(5):674–97.
Grossman AH, D’Augelli AR, Hershberger SL. Social support networks of lesbian, gay, and bisexual adults 60 years of age and older. J Gerentol. 1999;55:171–9.
Meyer IH. Prejudice and discrimination as social stressors. In: Meyer IH, Northridge ME, editors. The health of sexual minorities: public health perspectives on lesbian, gay, bisexual, and transgender populations. New York: Springer; 2007. p. 242–67.
Abercrombie HC, Speck NS, Monticelli RM. Endogenous cortisol elevations are related to memory facilitation only in individuals who are emotionally aroused. Psychoneuroendocrinology. 2006;31(2):187–96.
Bjorkman M, Malterud K. Lesbian women coping with challenges of minority stress: a qualitative study. Scand J Public Health. 2012;40(3):239–44.
Frost DM, Lehavot K, Meyer IH. Minority stress and physical health among sexual minority individuals. J Behav Med. 2015;38(1):1–8.
Lingiardi V, Baiocco R, Nardell N. Measures of internalized sexual stigma for lesbians and gay men: a new scale. J Homosex. 2012;59:1191–210.
Mason TB, Lewis RJ. Minority stress and binge eating among lesbian and bisexual women. J Homosex. 2015;62(7):971–92.
Szymanski DM, Chung YB. The lesbian internalized homophobia scale: a rational/theoretical approach. J Homosex. 2001;41(2):37–52.
Bockting WO, Miner MH, Swinburne Romine RE, Hamilton A, Coleman E. Stigma, mental health, and resilience in an online sample of the US transgender population. Am J Public Health. 2013;103(5):943–51.
Gamarel KE, Reisner SL, Laurenceau JP, Nemoto T, Operario D. Gender minority stress, mental health, and relationship quality: a dyadic investigation of transgender women and their cisgender male partners. J Fam Psychol. 2014;28(4):437–47.
Stuenkel D, Wong V. “Stigma” 8thChronic illness: Impact and interventions. 2013.
Stueknel DL, Wong VK. Stigma. In: Larsen PD, Lubkin IM, editors. Chronic illness: impact and intervention. Boston: Jones and Bartlett; 2009.
Herek GM, Chopp R, Strohl D. Sexual stigma: putting sexual minority health issues in context. In: Meyer IH, Northridge ME, editors. The health of sexual minorities: public health perspectives on lesbian, gay, bisexual, and transgender populations. New York: Springer Science and Business Media; 2007. p. 171–208.
Weiss JM. GL vs. BT: the archaeology of biphobia and trans-phobia within the U.S. gay and lesbian community. J Bisexuality. 2004;3:25–55.
Worthen M. An argument for separate analyses of attitudes towards lesbian, gay, and bisexual women, MtF and Ftm transgender individuals. Sex Roles. 2013;68:703–23.
Warriner K, Nagoshi CT, Nagoshi JL. Correlates of homophobia, transphobia, and internalized homophobia in gay or lesbian and heterosexual samples. J Homosex. 2013;60:1297–314.
Hatzenbuehler ML. How does sexual minority stigma “get under the skin”? A psychological mediation framework. Psychol Bull. 2009;135(5):707–30.
Levine S. Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology. 2005;30(10):939–46.
Levine S, Ursin H. What is stress? In: Brown MR, Koob GF, Rivier C, editors. Stress neurobiology and neuroendocrinology. New York: Marcel Dekker; 1991. p. 3–21.
Dickerson SS, Kemeny ME. Acute stressors and cortisol reactivity: a meta-analytic review. Psychosom Med. 2002;54:105–23.
Lupien SJ, Ouelle-Morin, I., Hupback, A., Walker, D., Tu, M.T., Buss, C., Pruessner, J, McEwen, B.S. Beyond the stress concept: allostatic load – a developmental biological and cognitive perspective. In: Cicchetti D, editor. Handbook series on developmental psychopathology. Wisconsin 2006. p. 784–809.
Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000;21(1):55–89.
McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav. 2003;43:2–15.
McEwen BS, Weiss JM, Schwartz LS. Selective retention of corticosterone by limbic structures in rat brain. Nature. 1968;220(5170):911–2.
Gray TS, Bingaman EW. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit Rev Neurobiol. 1996;10(2):155–68.
Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 1985;117(6):2505–11.
Sanchez MM, Young LJ, Plotsky PM, Insel TR. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci. 2000;20(12):4657–68.
Thayer JF, Lane RD. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 2009;33(2):81–8.
McEwen BS. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci. 2004;1032:1–7.
Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10(6):434–45.
Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci. 1997;17(7):2492–8.
McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338(3):171–9.
Herek GM. Sexual stigma and sexual prejudice in the United States: a conceptual framework. In: Hope DA, editor. Contemporary perspectives on lesbian, gay, and bisexual identities. New York: Springer Science + Business Media; 2009. p. 65–111.
Huebner DM, Davis MC. Gay and bisexual men who disclose their sexual orientations in the workplace have higher workday levels of salivary cortisol and negative affect. Ann Behav Med. 2005;30(3):260–7.
Leserman J, Petitto JM, Golden RN, Gaynes BN, Gu H, Perkins DO, et al. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. Am J Psychiatry. 2000;157(8):1221–8.
Kertzner RM, Goetz R, Todak G, Cooper T, Lin SH, Reddy MM, et al. Cortisol levels, immune status, and mood in homosexual men with and without HIV infection. Am J Psychiatry. 1993;150(11):1674–8.
Hengge UR, Reimann G, Schafer A, Goos M. HIV-positive men differ in immunologic but not catecholamine response to an acute psychological stressor. Psychoneuroendocrinology. 2003;28(5):643–56.
Greeson JM, Hurwitz BE, Llabre MM, Schneiderman N, Penedo FJ, Klimas NG. Psychological distress, killer lymphocytes and disease severity in HIV/AIDS. Brain Behav Immun. 2008;22(6):901–11.
Antoni MH, Schneiderman N, Klimas N, LaPerriere A, Ironson G, Fletcher MA. Disparities in psychological, neuroendocrine, and immunologic patterns in asymptomatic HIV-1 seropositive and seronegative gay men. Biol Psychiatry. 1991;29(10):1023–41.
Gorman JM, Kertzner R, Cooper T, Goetz RR, Lagomasino I, Novacenko H, et al. Glucocorticoid level and neuropsychiatric symptoms in homosexual men with HIV infection. Am J Psychiatry. 1991;148(1):41–5.
Manuck SB. Cardiovascular reactivity in cardiovascular disease: "once more unto the breach". Int J Behav Med. 1994;1(1):4–31.
Lovallo WR. Cardiovascular responses to stress and disease outcomes: a test of the reactivity hypothesis. Hypertension. 2010;55(4):842–3.
Lovallo WR, Gerin W. Psychophysiological reactivity: mechanisms and pathways to cardiovascular disease. Psychosom Med. 2003;65(1):36–45.
Brosschot JF, Pieper S, Thayer JF. Expanding stress theory: prolonged activation and perseverative cognition. Psychoneuroendocrinology. 2005;30(10):1043–9.
Brosschot JF. Markers of chronic stress: prolonged physiological activation and (un)conscious perseverative cognition. Neurosci Biobehav Rev. 2010;35(1):46–50.
Rutledge T, Linden W, Paul D. Cardiovascular recovery from acute laboratory stress: reliability and concurrent validity. Psychosom Med. 2000;62(5):648–54.
Earle TL, Linden W, Weinberg J. Differential effects of harassment on cardiovascular and salivary cortisol stress reactivity and recovery in women and men. J Psychosom Res. 1999;46(2):125–41.
Linden W, Earle TL, Gerin W, Christenfeld N. Physiological stress reactivity and recovery: conceptual siblings separated at birth? J Psychosom Res. 1997;42(2):117–35.
Stewart JG, Mazurka R, Bond L, Wynne-Edwards KE, Harkness KL. Rumination and impaired cortisol recovery following a social stressor in adolescent depression. J Abnorm Child Psychol. 2013;41(7):1015–26.
Hatzenbuehler ML, McLaughlin KA, Nolen-Hoeksema S. Emotion regulation and internalizing symptoms in a longitudinal study of sexual minority and heterosexual adolescents. J Child Psychol Psychiatry. 2008;49(12):1270–8.
Hatzenbuehler ML, Nolen-Hoeksema S, Dovidio J. How does stigma “get under the skin”?: the mediating role of emotion regulation. Psychol Sci. 2009;20(10):1282–9.
Brondolo E, Monge A, Agosta J, Tobin JN, Cassells A, Stanton C, et al. Perceived ethnic discrimination and cigarette smoking: examining the moderating effects of race/ethnicity and gender in a sample of Black and Latino urban adults. J Behav Med. 2015;38(4):689–700.
Hatzenbuehler, M.L. and McLaughlin, K.A., 2014. Structural stigma and hypothalamic–pituitary–adrenocortical axis reactivity in lesbian, gay, and bisexual young adults. Ann Behav Med, 47(1), pp.39–47.
Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology. 2005;30(10):1010–6.
Juster RP, Hatzenbuehler ML, Mendrek A, Pfaus JG, Smith NG, Johnson PJ, et al. Sexual orientation modulates endocrine stress reactivity. Biol Psychiatry. 2015;77(7):668–76.
Kirschbaum C, Wust S, Hellhammer D. Consistent sex differences in cortisol responses to psychological stress. Psychosom Med. 1992;54(6):648–57.
Hatzenbuehler ML, McLaughlin KA. Structural stigma and hypothalamic-pituitary-adrenocortical axis reactivity in lesbian, gay, and bisexual young adults. Ann Behav Med. 2013;47:39–47.
Gunnar MR, Frenn K, Wewerka SS, Van Ryzin MJ. Moderate versus severe early life stress: associations with stress reactivity and regulation in 10–12-year-old children. Psychoneuroendocrinology. 2009;34(1):62–75.
MacMillan HL, Georgiades K, Duku EK, Shea A, Steiner M, Niec A, et al. Cortisol response to stress in female youths exposed to childhood maltreatment: results of the youth mood project. Biol Psychiatry. 2009;66(1):62–8.
Yehuda R, Halligan SL, Golier JA, Grossman R, Bierer LM. Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology. 2004;29(3):389–404.
Pruessner JC, Wolf OT, Hellhammer DH, Buske-Kirschbaum A, von Auer K, Jobst S, et al. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci. 1997;61(26):2539–49.
Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L. The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev. 2010;35(1):97–103.
Loucks E, Juster RP, Pruessner JC. Neuroendocrine biomarkers, allostatic load, and the challenge of measurement: a commentary on Gersten. Soc Sci Med. 2008;66:525–30.
Chida Y, Steptoe A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009;80(3):265–78.
Marchand A, Juster RP, Durand P, Lupien SJ. Burnout symptom sub-types and cortisol profiles: what’s burning most? Psychoneuroendocrinology. 2014;40:27–36.
Juster RP, Sindi S, Marin MF, Perna A, Hashemi A, Pruessner JC, et al. A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology. 2011;36(6):797–805.
Muhtz C, Zyriax BC, Klahn T, Windler E, Otte C. Depressive symptoms and metabolic risk: effects of cortisol and gender. Psychoneuroendocrinology. 2009;34(7):1004–11.
Deuschle M, Schweiger U, Weber B, Gotthardt U, Korner A, Schmider J, et al. Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab. 1997;82(1):234–8.
Benibgui M. Mental health challenges and resilience in lesbian, gay, and bisexual young adults: biological and psychological internalization of minority stress and victimization. Montreal: Concordia University; 2010.
Tejeda M. Nondiscrimination policies and sexual identity disclosure: do they make a difference in employee outcomes? Empl Responsib Rights J. 2006;18(1):45–59.
Juster RP, Smith NG, Ouellet E, Sindi S, Lupien SJ. Sexual orientation and disclosure in relation to psychiatric symptoms, diurnal cortisol, and allostatic load. Psychosom Med. 2013;75(2):103–16.
Sterling P, Eyer J. Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J, editors. Handbook of life stress, cognition and health. New York: Wiley; 1988. p. 629–49.
Cicchetti D. Annual Research Review: resilient functioning in maltreated children – past, present, and future perspectives. J Child Psychol Psychiatry. 2013;54(4):402–22.
McEwen BS, Stellar E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993;153(18):2093–101.
Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, et al. A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Dev Psychopathol. 2011;23(3):725–76.
Seeman E, Singer BH, Rowe J, Horwitz RI, McEwen B. Price of adaptation – allostatic load and its health consequences. Arch Intern Med. 1997;157:2259–68.
Singer B, Ryff CD, Seeman T. Operationalizing allostatic load. In: Schulkin J, editor. Allostasis, homeostasis, and the costs of psychological adaptation. New York: Cambridge University Press; 2004. p. 113–49.
Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010;35(1):2–16.
Juster RP, Ouellet E, Lefebvre-Louis JP, Sindi S, Johnson PJ, Smith NG, et al. Retrospective coping strategies during sexual identity formation and current biopsychosocial stress. Anxiety Stress Coping. 2016;29(2):119–38
DiFulvio GT. Sexual minority youth, social connection and resilience: from personal struggle to collective identity. Soc Sci Med. 2011;72(10):1611–7.
Snapp S, Watson RJ, Russell ST, Diaz RM, Ryan C. Social support networks for LGBT young adults: low cost strategies for positive adjustment. Fam Relat. 2015;64:420–30.
D’Augelli AR, Hershberger SL, Pilkington NW. Lesbian, gay, and bisexual youth and their families: disclosure of sexual orientation and its consequences. Am J Orthopsychiatry 1998;68(3):361–371; discussion 72–5.
Wright ER, Perry BL. Sexual identity distress, social support, and the health of gay, lesbian, and bisexual youth. J Homosex. 2006;51(1):81–110.
Pachankis JE, Hatzenbuehler ML, Hickson F, Weatherburn P, Berg RC, Marcus U, et al. Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey. AIDS. 2015;29(10):1239–46.
Fisher J, editor. The work stabilization in trauma treatment. Paper presented at Trauma Center Lecture Series, Boston; 1999.
Howard JM, Goelitz A. Psychoeducation as a response to community disaster. Brief Treat Crisis Intervent. 2004;4:1–10.
Johnson JL, Greaves L, Repta R. Better science with sex and gender: a primer of health research. Ottawa: Canadian Institutes for Health Research Institute of Gender and Health; 2007.
Herek GM, Garnets LD. Sexual orientation and mental health. Annu Rev Clin Psychol. 2007;3:353–75.
Hatzenbuehler ML. Social factors as determinants of mental health disparities in LGB populations: implications for public policy. Soc Issues Policy Rev. 2010;4(1):31–62.
Hatzenbuehler ML, Keyes KM, Hasin DS. State-level policies and psychiatric morbidity in lesbian, gay, and bisexual populations. Am J Public Health. 2009;99(12):2275–81.
Hatzenbuehler ML, Bellatorre A, Lee Y, Finch BK, Muennig P, Fiscella K. Structural stigma and all-cause mortality in sexual minority populations. Soc Sci Med. 2014;103:33–41.
Hatzenbuehler ML, McLaughlin KA, Keyes KM, Hasin DS. The impact of institutional discrimination on psychiatric disorders in lesbian, gay, and bisexual populations: a prospective study. Am J Public Health. 2010;100:452–9.
Hatzenbuehler ML, O’Cleirigh C, Mayer K, Safren SA, Bradford J. Effects of same-sex marriage laws on health care use and expenditures in sexual minority men: a quasi-natural experiment. Am J Public Health. 2012;102(2):285–91.
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Juster, RP., Vencill, J.A., Johnson, P.J. (2017). Impact of Stress and Strain on Current LGBT Health Disparities. In: Eckstrand, K., Potter, J. (eds) Trauma, Resilience, and Health Promotion in LGBT Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-54509-7_4
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