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Causes of Severe Obesity: Genes to Environment

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Psychiatric Care in Severe Obesity

Abstract

Obesity is a growing public health concern, both in the developed and developing world. It is associated with a number of complications including type 2 diabetes, dyslipidemia, hypertension, cardiovascular disease, nonalcoholic fatty liver disease, obstructive sleep apnea, and malignancy [1]. This causes considerable morbidity and increased mortality. Further, lifestyle changes such as diet and exercise and/or treatment with medications do not usually result in sustained weight loss [2, 3]. Bariatric surgery is the only treatment that results in sustained weight loss with resolution/improvement in obesity-associated complications [4]. Understanding the regulation of food intake and energy expenditure and ultimately body weight regulation is therefore of paramount importance and may ultimately need to better treatments of obesity and its complications. In this chapter, we will review the regulation of food intake and energy expenditure by genetic and environmental factors and how this pertains to the etiology of severe obesity.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine, Toronto General Hospital, University Health Network, 12EN-213, 200 Elizabeth Street, Toronto, ON, Canada, M5C 2C4

    Satya Dash Ph.D., M.B.B.S., F.R.C.P.C.

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Correspondence to Satya Dash Ph.D., M.B.B.S., F.R.C.P.C. .

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  1. Toronto Western Hospital Bariatric Surgery Program, Centre for Mental Health, University Health Network, Toronto, Ontario, Canada

    Sanjeev Sockalingam

  2. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

    Raed Hawa

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Dash, S. (2017). Causes of Severe Obesity: Genes to Environment. In: Sockalingam, S., Hawa, R. (eds) Psychiatric Care in Severe Obesity. Springer, Cham. https://doi.org/10.1007/978-3-319-42536-8_3

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