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The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases

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Oxygen Transport to Tissue XXXVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

Abstract

The first derivatives of gelatin and type I collagen fluorescence spectra were characterized in order to describe the effect of free radicals on pyridinoline (PYD) cross-links. The different gas saturation conditions were used to investigate the effect of different free radicals. An analysis of first derivative fluorescence spectra suggests that PYD cross-link fluorescence emission is composed of three peaks in gelatin, but only two in type I collagen. The PYD cross-link was photo-degraded more than other gases in the presence of O2. This suggests that the singlet oxygen (1O2) plays a key role when using photodynamic therapy to treat skin fibrosis disease with Hypocrellin B (HB).

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Acknowledgments

This work was financially supported by the National Nature Science Foundation of China (21362010), and the Yunnan Natural Science Foundation (2010ZC0153).

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Authors and Affiliations

  1. Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan, Province, P. R. China

    Heping Yan, Yashun Chen, Jucheng Zhang, Wei Liu & Rui Chen

  2. School of science, Honghe University, Mengzi, Yunnan, Province, P. R. China

    Heping Yan, Yashun Chen, Jucheng Zhang, Wei Liu & Rui Chen

Authors
  1. Heping Yan
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  2. Yashun Chen
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  3. Jucheng Zhang
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  4. Wei Liu
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  5. Rui Chen
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Corresponding author

Correspondence to Jucheng Zhang .

Editor information

Editors and Affiliations

  1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Qingming Luo

  2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Lin Z. Li

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Hua Shi

  5. ISOTT Historian, Ellicott City, Maryland, USA

    Duane F. Bruley

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© 2016 Springer International Publishing Switzerland

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Yan, H., Chen, Y., Zhang, J., Liu, W., Chen, R. (2016). The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_10

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