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Intestinal Microbiology and Ecology in Crohn’s Disease and Ulcerative Colitis

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Crohn's Disease and Ulcerative Colitis

Abstract

Inflammatory bowel diseases (IBD) include the two main phenotypes Crohn’s disease (CD) and ulcerative colitis (UC) both characterized by intermittent conditions of chronic and relapsing inflammation in the entire gastrointestinal tract or colon, respectively. Disease initiation and perturbation is triggered by environmental factors in genetically susceptible individuals [1, 2]. Genome-wide association studies (GWAS) and animal data provide evidence for an interrelated role of the intestinal microbiota, epithelial interface, and immune system in the pathogenesis of IBD [3–6]. This chapter provides an overview of the current state of research on the role of the intestinal microbiota in CD and UC. In addition, approaches to the treatment of IBD by the modulation of the intestinal microbiota are discussed.

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  1. Technische Universität München, Gregor-Mendel-Str. 2, Freising-Weihenstephan, 85354, Germany

    Ludovica F. Buttó Ph.D. (Chair of Nutrition and Immunology) & Dirk Haller Ph.D.

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  1. Ludovica F. Buttó Ph.D.
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  1. Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Charité Medical School—Humboldt-University of Berlin, Berlin, Germany

    Daniel C. Baumgart

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Buttó, L.F., Haller, D. (2017). Intestinal Microbiology and Ecology in Crohn’s Disease and Ulcerative Colitis. In: Baumgart, D. (eds) Crohn's Disease and Ulcerative Colitis. Springer, Cham. https://doi.org/10.1007/978-3-319-33703-6_4

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