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Paradigm of T Cell Differentiation in IBD

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Crohn's Disease and Ulcerative Colitis

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Abstract

Inflammatory bowel disease (IBD) usually takes a persistent course, and this feature suggests the importance of acquired immunity in the pathogenesis of IBD such as Crohn’s disease (CD) and ulcerative colitis (UC). Helper T (Th) cells differentiated from CD4+ naïve T cells play central roles in the acquired immune system. Th cells are classified as Th1, Th2, Th17, or Treg. In addition, other newly defined Th subsets have also been reported recently. CD was originally thought to be Th1-mediated disease, while UC was thought to be Th2-mediated. However, it has been recently reported that other Th subsets are also involved in the pathogenesis of IBD as well as in multiple animal models. Although Th subsets have become more complexed, it may be helpful for the establishment of future immunologic therapy for IBD.

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Authors and Affiliations

  1. Department of Gastroenterology, Tokyo Medical and Dental University, Tokyo, Japan

    Takashi Nagaishi M.D., Ph.D. & Mamoru Watanabe M.D., Ph.D.

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  1. Takashi Nagaishi M.D., Ph.D.
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  2. Mamoru Watanabe M.D., Ph.D.
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Correspondence to Takashi Nagaishi M.D., Ph.D. .

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Editors and Affiliations

  1. Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Charité Medical School—Humboldt-University of Berlin, Berlin, Germany

    Daniel C. Baumgart

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Nagaishi, T., Watanabe, M. (2017). Paradigm of T Cell Differentiation in IBD. In: Baumgart, D. (eds) Crohn's Disease and Ulcerative Colitis. Springer, Cham. https://doi.org/10.1007/978-3-319-33703-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-33703-6_14

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