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The Comorbid Diagnosis of ASD and ADHD: Clinical and Neuropsychological Perspectives

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Handbook of Assessment and Diagnosis of Autism Spectrum Disorder

Part of the book series: Autism and Child Psychopathology Series ((ACPS))

Abstract

A considerable research base has recently emerged showing high rates of overlap between autism and ADHD. This chapter discusses methods of assessing ADHD, with an emphasis on how this is performed in an autism population.

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References

  • Abikoff, H. B., Jensen, P. S., & Arnold, L. L. (2002). Observed classroom behavior of children with ADHD: Relationship to gender and comorbidity. Journal of Abnormal Child Psychology, 30, 349–359.

    PubMed  Google Scholar 

  • Adamo, N., Huo, L., Adelsberg, S., Petkova, E., Castellanos, F. X., & Di Martino, A. (2014). Response time intra-subject variability: Commonalities between children with autism spectrum disorders and children with ADHD. European Child & Adolescent Psychiatry, 23(2), 69–79.

    Google Scholar 

  • Aman, M. G., & Langworthy, K. S. (2000). Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders. Journal of Autism and Developmental Disorders, 30(5), 451–459.

    PubMed  Google Scholar 

  • American Academy of Child and Adolescent Psychiatry. (2007). Practice parameter for attention deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 894–921.

    Google Scholar 

  • American Academy of Neurology. (2000). Practice parameter: Screening and diagnosis of autism. Neurology, 55, 468–479.

    Google Scholar 

  • American Academy of Pediatrics. (2011). ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. doi:10.1542/peds.2011-2654.

    Article  Google Scholar 

  • Ames, C. S., & White, S. J. (2011). Brief report: Are ADHD traits dissociable from the autistic profile? Links between cognition and behaviour. Journal of Autism and Developmental Disorders, 41(3), 357–363.

    PubMed  Google Scholar 

  • Anagnostou, E., & Taylor, M. J. (2011). Review of neuroimaging in autism spectrum disorders: What have we learned and where we go from here. Molecular Autism, 2(1), 4.

    PubMed  PubMed Central  Google Scholar 

  • Antrop, I., Stock, P., Verté, S., Wiersema, J. R., Baeyens, D., & Roeyers, H. (2006). ADHD and delay aversion: The influence of non-temporal stimulation on choice for delayed rewards. Journal of Child Psychology and Psychiatry, 47(11), 1152–1158.

    PubMed  Google Scholar 

  • Antshel, K., & Hier, B. (2014). Attention deficit hyperactivity disorder (ADHD) in children with autism spectrum disorders. In V. B. Patel, V. R. Preedy, & C. R. Martin (Eds.), Comprehensive guide to autism (pp. 1013–1029). New York, NY: Springer.

    Google Scholar 

  • APA. (2013). Diagnostic and statistical manual of mental disorders 5. Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Baio, J. (2012). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, 14 Sites, United States, 2008. Morbidity and Mortality Weekly Report. Surveillance Summaries, 61(3), 1–19. Centers for Disease Control and Prevention.

    Google Scholar 

  • Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2007a). Long-term school outcomes for children with attention-deficit/hyperactivity disorder: A population-based perspective. Journal of Developmental and Behavioral Pediatrics, 28(4), 265–273. doi:10.1097/DBP.0b013e31811ff87d.

    Article  PubMed  Google Scholar 

  • Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2007b). Modifiers of long-term school outcomes for children with attention-deficit/hyperactivity disorder: Does treatment with stimulant medication make a difference? Results from a population-based study. Journal of Developmental and Behavioral Pediatrics, 28(4), 274–287. doi:10.1097/DBP.0b013e3180cabc28.

    Article  PubMed  Google Scholar 

  • Bar-Haim, Y., Shulman, C., Lamy, D., & Reuveni, A. (2006). Attention to eyes and mouth in high-functioning children with autism. Journal of Autism and Developmental Disorders, 36(1), 131–137. doi:10.1007/s10803-005-0046-1.

    Article  PubMed  Google Scholar 

  • Barkley, R. A. (2006). Attention-deficit hyperactivity disorder. A handbook for diagnosis and treatment (3rd ed.). New York, NY: Guilford Press.

    Google Scholar 

  • Baron-Cohen, S., Wheelwright, S., & Jolliffe, T. (1997). Is there a “language of the eyes”? Evidence from normal adults, and adults with autism or Asperger syndrome. Visual Cognition, 4(3), 311–331. doi:10.1080/713756761.

    Article  Google Scholar 

  • Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. doi:10.1023/a:1005653411471.

    Article  PubMed  Google Scholar 

  • Bekker, J., Bruck, D., & Sciberras, E. (2013). Congruent validity of the Strength and Difficulties Questionnaire to screen for comorbidities in children with attention deficit hyperactivity disorder. Journal of Attention Disorders 1087054713496462, first published on July 23, 2013 as doi:10.1177/1087054713496462.

    Google Scholar 

  • Biderman, J., Quinn, D., Weiss, M., Markabi, S., Weidenman, M., Edson, K., … Wigal, S. (2003). Efficacy and safety of Ritalin LA, a new, once daily, extended-release dosage form of methylphenidate, in children with attention deficit hyperactivity disorder. Paediatric Drugs, 5, 833–841.

    Google Scholar 

  • Biederman, J., Faraone, S., Milberger, S., Guite, J., Mick, E., Chen, L., … Perrin, J. (1996). A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Archives of General Psychiatry, 53(5), 437–446.

    Google Scholar 

  • Biederman, J., Newcorn, J., & Sprich, S. (1991a). Comorbidity of AD/HD with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry, 148, 546–577.

    Google Scholar 

  • Biederman, J., Newcorn, J., & Sprich, S. (1991b). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. The American Journal of Psychiatry, 148(5), 564–577.

    PubMed  Google Scholar 

  • Biel, M. G., & McGee, M. E. (2011). Assessment of attention-deficit/hyperactivity disorder. Pediatric Annals, 40(10), 493–498. doi:10.3928/00904481-20110914-06.

    Article  PubMed  Google Scholar 

  • Bishop, D. V. (2003). Children’s communication checklist (2nd ed.). San Antonio, TX: Pearson.

    Google Scholar 

  • Brieber, S., Neufang, S., Bruning, N., Kamp-Becker, I., Remschmidt, H., Herpertz-Dahlmann, B., … Konrad, K. (2007). Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 48(12), 1251–1258.

    Google Scholar 

  • Buderath, P., Gärtner, K., Frings, M., Christiansen, H., Schoch, B., Konczak, J., … Timmann, D. (2009). Postural and gait performance in children with attention deficit/hyperactivity disorder. Gait & Posture, 29(2), 249–254.

    Google Scholar 

  • Bühler, E., Bachmann, C., Goyert, H., Heinzel-Gutenbrunner, M., & Kamp-Becker, I. (2011). Differential diagnosis of autism spectrum disorder and attention deficit hyperactivity disorder by means of inhibitory control and ‘theory of mind’. Journal of Autism and Developmental Disorders, 41(12), 1718–1726.

    PubMed  Google Scholar 

  • Busch, B., Biederman, J., Cohen, L. G., Sayer, J. M., Monuteaux, M. C., Mick, E., … Faraone, S. V. (2002). Correlates of ADHD among children in pediatric and psychiatric clinics. Psychiatric Services, 53(9), 1103–1111.

    Google Scholar 

  • Bush, G. (2011). Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder. Biological Psychiatry, 69(12), 1160–1167.

    PubMed  PubMed Central  Google Scholar 

  • Castellanos, F. X., Sonuga-Barke, E. J., Milham, M. P., & Tannock, R. (2006). Characterizing cognition in ADHD: Beyond executive dysfunction. Trends in Cognitive Sciences, 10(3), 117–123.

    PubMed  Google Scholar 

  • Cherkasova, M., Sulla, E. M., Dalena, K. L., Pondé, M. P., & Hechtman, L. (2013). Developmental course of attention deficit hyperactivity disorder and its predictors. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 22, 47–54.

    PubMed  PubMed Central  Google Scholar 

  • Clark, T., Feehan, C., Tinline, C., & Vostanis, P. (1999). Autistic symptoms in children with attention deficit-hyperactivity disorder. European Child & Adolescent Psychiatry, 8(1), 50–55.

    Google Scholar 

  • Cole, W., Mostofsky, S., Larson, J. G., Denckla, M., & Mahone, E. (2008). Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology, 71, 1514–1520.

    PubMed  PubMed Central  Google Scholar 

  • Constantino, J. N. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services.

    Google Scholar 

  • Corbett, B. A., Constantine, L. J., Hendren, R., Rocke, D., & Ozonoff, S. (2009). Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Research, 166(2–3), 210–222. doi:10.1016/j.psychres.2008.02.005.

    Article  PubMed  PubMed Central  Google Scholar 

  • Courchesne, E. (2004). Brain development in autism: Early overgrowth followed by premature arrest of growth. Mental Retardation and Developmental Disabilities Research Reviews, 10(2), 106–111.

    PubMed  Google Scholar 

  • Cussen, A., Sciberras, E., Ukoumunne, O. C., & Efron, D. (2012). Relationship between symptoms of attention-deficit/hyperactivity disorder and family functioning—A community-based study. European Pediatrics, 171, 271–280.

    Google Scholar 

  • Daley, D., van der Oord, S., Ferrin, M., Danckaerts, M., Doepfner, M., Cortese, S., … European ADHD Guidelines Group. (2014). Behavioral interventions in Attention-Deficit/Hyperactivity Disorder: A meta-analysis of randomized controlled trials across multiple outcome domains. Journal of the American Academy of Child and Adolescent Psychiatry, 53(8), 835–847.

    Google Scholar 

  • Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., … Davidson, R. J. (2005). Gaze fixation and the neural circuitry of face processing in autism. Nature Neuroscience, 8(4), 519–526. doi:10.1038/nn1421

  • Danckaerts, M., Sonuga-Barke, E. J. S., Banaschewski, T., Buitelaar, J., Dopfner, M., Hollis, C., … Coghill, D. (2010). The quality of life of children with attention deficit/hyperactivity disorder: A systematic review. European Child & Adolescent Psychiatry, 19(2), 83–105. doi:10.1007/s00787-009-0046-3

  • De Giacomo, A., & Fombonne, E. (1998). Parental recognition of developmental abnormalities in autism. European Child & Adolescent Psychiatry, 7(3), 131–136.

    Google Scholar 

  • Dekker, M. C., & Koot, H. M. (2003). DSM-IV disorders in children with borderline to moderate intellectual disability. I: Prevalence and impact. Journal of the American Academy of Child and Adolescent Psychiatry, 42(8), 915–922.

    PubMed  Google Scholar 

  • Demurie, E., Roeyers, H., Baeyens, D., & Sonuga-Barke, E. (2011). Common alterations in sensitivity to type but not amount of reward in ADHD and autism spectrum disorders. Journal of Child Psychology and Psychiatry, 52(11), 1164–1173.

    PubMed  Google Scholar 

  • Di Martino, A., Zuo, X.-N., Kelly, C., Grzadzinski, R., Mennes, M., Schvarcz, A., … Milham, M. P. (2013). Shared and distinct intrinsic functional network centrality in autism and attention-deficit/hyperactivity disorder. Biological Psychiatry, 74(8), 623–632.

    Google Scholar 

  • Durston, S., van Belle, J., & de Zeeuw, P. (2011). Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biological Psychiatry, 69(12), 1178–1184.

    PubMed  Google Scholar 

  • Efron, D., Sciberras, E., Anderson, V., Hazell, P., Ukoumunne, O., Jongeling, B., … Nicholson, J. M. (2014). A controlled community study of functional status in Attention-Deficit/Hyperactivity Disorder at age 6–8. Pediatrics, 134, e992–e1000.

    Google Scholar 

  • Ehlers, S., Gillberg, C., & Wing, L. (1999). A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age children. Journal of Autism and Developmental Disorders, 29(2), 129–141.

    PubMed  Google Scholar 

  • Ehlers, S., Nydén, A., Gillberg, C., Sandberg, A. D., Dahlgren, S.-O., Hjelmquist, E., & Odén, A. (1997). Asperger syndrome, autism and attention disorders: A comparative study of the cognitive profiles of 120 children. Journal of Child Psychology and Psychiatry, 38(2), 207–217.

    Google Scholar 

  • Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57(11), 1313–1323.

    Google Scholar 

  • Faraone, S. V., Perlis, R. H., & Doyle, A. E. (2005b). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1313–1323.

    PubMed  Google Scholar 

  • Faraone, S. V., Short, E. J., Biederman, J., Findling, R. L., Roe, C., & Manos, M. J. (2002). Adderall and methylphenidate in attention deficit hyperactivity disorder: a drug-placebo and drug-drug response curve analysis of a naturalistic study. International Journal of Neuropsychopharmacology, 5, 121–129.

    PubMed  Google Scholar 

  • Feldman, H. M., & Reiff, M. I. (2014). Attention deficit-hyperactivity disorder in children and adolescents. New England Journal of Medicine, 370, 9.

    Google Scholar 

  • Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33(4), 365–382. doi:10.1023/A:1025054610557.

    Article  PubMed  Google Scholar 

  • Frazier, J., Biederman, J., Bellordre, C., Garfield, S., Geller, D., Coffey, B., & Faraone, S. (2001). Should the diagnosis of attention-deficit/hyperactivity disorder be considered in children with pervasive developmental disorder? Journal of Attention Disorders, 4(4), 203–211. doi:10.1177/108705470100400402

  • Gargaro, B., May, T., Tonge, B., Sheppard, D., Bradshaw, J., & Rinehart, N. (2014). Using the DBC-P hyperactivity index to screen for ADHD in young people with autism and ADHD: A pilot study. Research in Autism Spectrum Disorders, 8(9), 1008–1015.

    Google Scholar 

  • Gargaro, B. A., Rinehart, N. J., Bradshaw, J. L., Tonge, B. J., & Sheppard, D. M. (2011). Autism and ADHD: How far have we come in the comorbidity debate? Neuroscience & Biobehavioral Reviews, 35(5), 1081–1088.

    Google Scholar 

  • Geurts, H. M., Broeders, M., & Nieuwland, M. S. (2010). Thinking outside the executive functions box: Theory of mind and pragmatic abilities in attention deficit/hyperactivity disorder. European Journal of Developmental Psychology, 7(1), 135–151.

    Google Scholar 

  • Geurts, H. M., Grasman, R. P., Verté, S., Oosterlaan, J., Roeyers, H., van Kammen, S. M., & Sergeant, J. A. (2008). Intra-individual variability in ADHD, autism spectrum disorders and Tourette’s syndrome. Neuropsychologia, 46(13), 3030–3041.

    Google Scholar 

  • Geurts, H. M., Verté, S., Oosterlaan, J., Roeyers, H., Hartman, C. A., Mulder, E. J., … Sergeant, J. A. (2004). Can the Children’s Communication Checklist differentiate between children with autism, children with ADHD, and normal controls? Journal of Child Psychology and Psychiatry, 45(8), 1437–1453.

    Google Scholar 

  • Ghanizadeh, A., Mohammadi, M. R., & Moini, R. (2008). Comorbidity of psychiatric disorders and parental psychiatric disorders in a sample of Iranian children with ADHD. Journal of Attention Disorders, 12(2), 149–155. doi:10.1177/1087054708314601.

    Article  PubMed  Google Scholar 

  • Gillberg, C., & De Souza, L. (2002). Head circumference in autism, Asperger syndrome, and ADHD: A comparative study. Developmental Medicine and Child Neurology, 44(05), 296–300.

    PubMed  Google Scholar 

  • Goldman, L. S., Genel, M., Bezman, R. J., & Slanetz, P. J. (1998). Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Journal of the American Medical Association, 279, 1100–1107.

    PubMed  Google Scholar 

  • Graetz, B., Sawyer, M., Hazell, P., Arney, F., & Baghurst, P. (2001). Validity of DSM-IV ADHD subtypes in a nationally representative sample of Australian children & adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 410–1417.

    Google Scholar 

  • Groenman, A. P., Oosterlaan, J., Rommelse, N. N. J., Franke, B., Greven, C. U., Hoekstra, P. J., … Faraone, S. V. (2013). Stimulant treatment for attention-deficit hyperactivity disorder and risk of developing substance use disorder. British Journal of Psychiatry, 203(2), 112–119. doi:10.1192/bjp.bp.112.124784

  • Grzadzinski, R., Di Martino, A., Brady, E., Mairena, M. A., O’Neale, M., Petkova, E., … Castellanos, F. X. (2011). Examining autistic traits in children with ADHD: Does the autism spectrum extend to ADHD? Journal of Autism and Developmental Disorders, 41(9), 1178–1191.

    Google Scholar 

  • Handen, B. L., Johnson, C. R., & Lubetsky, M. (2000). Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder. Journal of Autism and Developmental Disorders, 30(3), 245–255.

    PubMed  Google Scholar 

  • Harms, M. B., Martin, A., & Wallace, G. L. (2010). Facial emotion recognition in autism spectrum disorders: A review of behavioral and neuroimaging studies. Neuropsychology Review, 20(3), 290–322.

    PubMed  Google Scholar 

  • Harpin, V. (2005). The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Archives of Disease in Childhood, 90, i2–i7.

    PubMed  PubMed Central  Google Scholar 

  • Harpin, V., Mazzone, L., & Raynaud, J. P. (2013). Long-term outcomes of ADHD: A systematic review of self-esteem and social function. Journal of Attention Disorders. Published online before print May 22, 2013, doi: 10.1177/1087054713486516.

    Google Scholar 

  • Hartley, S. L., & Sikora, D. M. (2009). Which DSM-IV-TR criteria best differentiate high-functioning autism spectrum disorder from ADHD and anxiety disorders in older children? Autism, 13(5), 485–509.

    PubMed  PubMed Central  Google Scholar 

  • Hattori, J., Ogino, T., Abiru, K., Nakano, K., Oka, M., & Ohtsuka, Y. (2006). Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders? Brain & Development, 28(6), 371–374. doi:10.1016/j.braindev.2005.11.009.

    Article  Google Scholar 

  • Hiscock, H., Sciberras, E., Mensah, F., Gerner, B., Efron, D., Khano, S., & Oberklaid, F. (2015). Impact of a behavioral sleep intervention on ADHD symptoms, child sleep and parent health: A randomized controlled trial. BMJ, 350, h68.

    Google Scholar 

  • Hofvander, B., Delorme, R., Chaste, P., Nyden, A., Wentz, E., Stahlberg, O., … Leboyer, M. (2009). Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry, 9, 35.

    Google Scholar 

  • Holtmann, M., Bolte, S., & Poustka, F. (2007). Attention deficit hyperactivity disorder symptoms in pervasive developmental disorders: Association with autistic behavior domains and coexisting psychopathology. Psychopathology, 40(3), 172–177. doi:10.1159/000100007.

    Article  PubMed  Google Scholar 

  • Jensen, V. K., Larrieu, J. A., & Mack, K. K. (1997). Differential diagnosis between attention-deficit/hyperactivity disorder and pervasive developmental disorder—not otherwise specified. Clinical pediatrics, 36(10), 555–561.

    Google Scholar 

  • Jensen, P. S., Arnold, L. E., Swanson, J. M., Vitiello, B., Abikoff, H. B., Greenhill, L. L., … Hur, K. (2007). 3-Year follow-up of the NIMH MTA study. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 989–1002. doi:10.1097/chi.0b013e3180686d48

  • Johnson, C. P., & Myers, S. M. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120(5), 1183–1215.

    PubMed  Google Scholar 

  • Johnson, K. A., Robertson, I. H., Kelly, S. P., Silk, T. J., Barry, E., Daibhis, A., … Bellgrove, M. A. (2007). Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia, 45(10), 2234–2245. doi:10.1016/j.neuropsychologia.2007.02.019

  • Johnston, C., & Mash, E. J. (2001). Families of children with attention-deficit/hyperactivity disorder: Review and recommendations for future research. Clinical Child and Family Psychology Review, 4, 183–207.

    PubMed  Google Scholar 

  • Joshi, G., Faraone, S. V., Wozniak, J., Tarko, L., Fried, R., Galdo, M., … Biederman, J. (2014). Symptom profile of ADHD in youth with high-functioning autism spectrum disorder. A comparative study in psychiatrically referred populations. Journal of Attention Disorders, 1087054714543368.

    Google Scholar 

  • Kamp-Becker, I., Ghahreman, M., Heinzel-Gutenbrunner, M., Peters, M., Remschmidt, H., & Becker, K. (2013). Evaluation of the revised algorithm of Autism Diagnostic Observation Schedule (ADOS) in the diagnostic investigation of high-functioning children and adolescents with autism spectrum disorders. Autism, 17(1), 87–102.

    PubMed  Google Scholar 

  • Klein, R. G., Mannuzza, S., Olazagasti, M. A., Roizen, E., Hutchison, J. A., Lashua, E. C., & Castellanos, F. X. (2012). Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Archives of General Psychiatry, 69(12), 1295–1303. doi:10.1001/archgenpsychiatry.2012.271

  • Klin, A., Saulnier, C. A., Sparrow, S. S., Cicchetti, D. V., Volkmar, F. R., & Lord, C. (2007). Social and communication abilities and disabilities in higher functioning individuals with autism spectrum disorders: The Vineland and the ADOS. Journal of Autism and Developmental Disorders, 37(4), 748–759.

    PubMed  Google Scholar 

  • Konst, M. J., Matson, J. L., Goldin, R., & Rieske, R. (2014). How does ASD symptomology correlate with ADHD presentations? Research in Developmental Disabilities, 35(9), 2252–2259. doi:10.1016/j.ridd.2014.05.017.

    Article  PubMed  Google Scholar 

  • Lahey, B. B., Pelham, W. E., Loney, J., Kipp, H., Ehrhardt, A., Lee, S. S., … Massetti, G. (2004). Three-year predictive validity of DSM-IV attention deficit hyperactivity disorder in children diagnosed at 4–6 years of age. American Journal of Psychiatry, 161(11), 2014–2020.

    Google Scholar 

  • Langberg, J. M., & Becker, S. P. (2012). Does long-term medication use improve the academic outcomes of youth with attention-deficit/hyperactivity disorder? Clinical Child and Family Psychology Review, 15, 215–233.

    PubMed  Google Scholar 

  • Lange, K. W., Reichl, S., Lange, K. M., & Tucha, O. (2010). The history of attention deficit hyperactivity disorder. Attention Deficit Hyperactivity Disorder, 2, 241–255.

    Google Scholar 

  • Law, E. C., Sideridis, G. D., Prock, L. A., & Sheridan, M. A. (2014). Attention-deficit/hyperactivity disorder in young children: Predictors of diagnostic stability. Pediatrics, 133(4), 659–667.

    PubMed  PubMed Central  Google Scholar 

  • Lichtenstein, P., Carlström, E., Råstam, M., Gillberg, C., & Anckarsäter, H. (2010). The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. American Journal of Psychiatry, 167(11), 1357–1363.

    PubMed  Google Scholar 

  • Lim, L., Chantiluke, K., Cubillo, A., Smith, A., Simmons, A., Mehta, M., & Rubia, K. (2014). Disorder-specific grey matter deficits in attention deficit hyperactivity disorder relative to autism spectrum disorder. Psychological medicine, 45(5), 965–976.

    Google Scholar 

  • Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006). Autism from 2 to 9 years of age. Archives of General Psychiatry, 63(6), 694–701. doi:10.1001/archpsyc.63.6.694.

    Article  PubMed  Google Scholar 

  • Lord, C., Risi, S., Lambrecht, L., Cook, E., Jr., Leventhal, B., DiLavore, P., … Rutter, M. (2000). The autism diagnostic observation schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. doi:10.1023/a:1005592401947

  • Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.

    PubMed  Google Scholar 

  • Mahajan, R., Bernal, M. P., Panzer, R., Whitaker, A., Roberts, W., Handen, B., … Veenstra-VanderWeele, J. (2012). Clinical practice pathways for evaluation and medication choice for attention-deficit/hyperactivity disorder symptoms in autism spectrum disorders. Pediatrics, 130(Supplement 2), S125–S138.

    Google Scholar 

  • Marco, R., Miranda, A., Schlotz, W., Melia, A., Mulligan, A., Müller, U., … Gabriels, I. (2009). Delay and reward choice in ADHD: An experimental test of the role of delay aversion. Neuropsychology, 23(3), 367.

    Google Scholar 

  • Martin, J., Hamshere, M. L., O’Donovan, M. C., Rutter, M., & Thapar, A. (2014). Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders, 44(1), 204–215.

    PubMed  Google Scholar 

  • Matson, J. L., & Shoemaker, M. (2009). Intellectual disability and its relationship to autism spectrum disorders. Research in Developmental Disabilities, 30(6), 1107–1114. doi:10.1016/j.ridd.2009.06.003.

    Article  PubMed  Google Scholar 

  • May, T., Cornish, K., & Rinehart, N. J. (2012). Gender profiles of behavioral attention in children with autism spectrum disorder. Journal of Attention Disorders. doi:10.1177/1087054712455502.

    Article  PubMed  Google Scholar 

  • May, T., Cornish, K., & Rinehart, N. (2014). Does gender matter? A one year follow-up of autistic, attention and anxiety symptoms in high-functioning children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(5), 1077–1086.

    PubMed  Google Scholar 

  • Mayes, S. D., & Calhoun, S. L. (2003). Ability profiles in children with autism. Autism, 7(1), 65–80. doi:10.1177/1362361303007001006.

    Article  PubMed  Google Scholar 

  • Mayes, S. D., & Calhoun, S. L. (2008). WISC-IV and WIAT-II profiles in children with high-functioning autism. Journal of Autism and Developmental Disorders, 38(3), 428–439.

    PubMed  Google Scholar 

  • Mayes, S. D., Calhoun, S. L., Mayes, R. D., & Molitoris, S. (2012). Autism and ADHD: Overlapping and discriminating symptoms. Research in Autism Spectrum Disorders, 6(1), 277–285.

    Google Scholar 

  • Mayes, S. D., Calhoun, S. L., Murray, M. J., Morrow, J. D., Yurich, K. K. L., Cothren, S., … Petersen, C. (2012). Use of the Childhood Autism Rating Scale (CARS) for children with high functioning autism or Asperger syndrome. Focus on Autism and Other Developmental Disabilities, 27(1), 31–38. doi:10.1177/1088357611406902

  • Mulligan, A., Anney, R. J., O’Regan, M., Chen, W., Butler, L., Fitzgerald, M., … Minderaa, R. (2009). Autism symptoms in attention-deficit/hyperactivity disorder: A familial trait which correlates with conduct, oppositional defiant, language and motor disorders. Journal of Autism and Developmental Disorders, 39(2), 197–209.

    Google Scholar 

  • Murray, M. J. (2010). Attention-deficit/hyperactivity disorder in the context of autism spectrum disorders. Current Psychiatry Reports, 12(5), 382–388.

    PubMed  Google Scholar 

  • National Health and Medical Research Council. (2012). Clinical Practice Points on the diagnosis, assessment and management of Attention Deficit Hyperactivity Disorder in children and adolescents. Retrieved from http://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/ch54_draft_guidelines.pdf

  • Neale, B. M., Medland, S. E., Ripke, S., Asherson, P., Franke, B., Lesch, K. P., … Psychiat, G. C. A. S. (2010). Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 884–897. doi:10.1016/j.jaac.2010.06.008

  • NICE clinical guideline 72. (2008). Attention deficit hyperactivity disorder: Diagnosis and management of ADHD in children, young people and adults. Leicester, UK: National Health Service.

    Google Scholar 

  • Nigg, J. T. (2013). Attention-deficit/hyperactivity disorder and adverse health outcomes. Clinical Psychology Review, 33(2), 215–228. doi:10.1016/j.cpr.2012.11.005.

    Article  PubMed  Google Scholar 

  • Owens, J. S., Goldfine, M. E., Evangelista, N. M., Hoza, B., & Kaiser, N. M. (2007). A critical review of self perceptions and the positive illusory bias in children with ADHD. Clinical Child and Family Psychology Review, 10, 335–351.

    PubMed  Google Scholar 

  • Pan, C.-Y., Tsai, C.-L., & Chu, C.-H. (2009). Fundamental movement skills in children diagnosed with autism spectrum disorders and attention deficit hyperactivity disorder. Journal of Autism and Developmental Disorders, 39(12), 1694–1705.

    PubMed  Google Scholar 

  • Papadopoulos, N., Rinehart, N., Bradshaw, J. L., & McGinley, J. L. (2013). Brief report: Children with ADHD without co-morbid autism do not have impaired motor proficiency on the movement assessment battery for children. Journal of Autism and Developmental Disorders, 43(6), 1477–1482.

    PubMed  Google Scholar 

  • Paris, J., Mattick, R. P., McLaren, J., Degenhardt, L., Hall, W., Voruganti, L. N., … Parker, G. (2006). Inattention, hyperactivity, and impulsivity in teenagers with intellectual disabilities, with and without autism. Canadian Journal of Psychiatry, 51, 598–606.

    Google Scholar 

  • Pastor, P. N., & Reuben, C. A. (2008). Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004–2006. Vital and Health Statistics, 10(237), 1–14.

    Google Scholar 

  • Pelham, W. E., Jr., & Fabiano, G. A. (2008). Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184–214.

    PubMed  Google Scholar 

  • Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37(1), 51–87. doi:10.1111/j.1469-7610.1996.tb01380.x.

    Article  PubMed  Google Scholar 

  • Pfiffner, L. J., Mikami, A. Y., Huang-Pollock, C., Easterlin, B., Zalecki, C., & McBurnett, K. (2007). A randomized, controlled trial of integrated home-school behavioral treatment for ADHD, predominantly inattentive type. Journal of the American Academy of Child and Adolescent Psychiatry, 46(8), 1041–1050. doi:10.1097/chi.0b013e313064675f.

    Article  PubMed  Google Scholar 

  • Reiersen, A. M., Constantino, J. N., Grimmer, M., Martin, N. G., & Todd, R. D. (2008). Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Research and Human Genetics, 11(06), 579–585.

    PubMed  PubMed Central  Google Scholar 

  • Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autistic traits in a population-based ADHD twin sample. Journal of Child Psychology and Psychiatry, 48(5), 464–472.

    PubMed  Google Scholar 

  • Reynolds, C. R. (2004). Behavior assessment system for children. Wiley Online Library.

    Google Scholar 

  • Rinehart, N., Tonge, B., Bradshaw, J., Iansek, R., Enticott, P., & McGinley, J. (2006). Gait function in high-functioning autism and Asperger’s disorder. European Child & Adolescent Psychiatry, 15(5), 256–264. doi:10.1007/s00787-006-0530-y.

    Article  Google Scholar 

  • Roizen, N. J., Blondis, T. A., Irwin, M., & Stein, M. (1994). Adaptive functioning in children with attention-deficit hyperactivity disorder. Archives of Pediatrics & Adolescent Medicine, 148(11), 1137–1142.

    Google Scholar 

  • Rommelse, N. N., Franke, B., Geurts, H. M., Hartman, C. A., & Buitelaar, J. K. (2010). Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. European Child & Adolescent Psychiatry, 19(3), 281–295.

    Google Scholar 

  • Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P., & Plomin, R. (2008). Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of Child Psychology and Psychiatry, 49(5), 535–542.

    PubMed  Google Scholar 

  • Rubia, K., Alegria, A. A., & Brinson, H. (2014). Brain abnormalities in attention-deficit hyperactivity disorder: A review. Revista De Neurologia, 58, S3–S18.

    PubMed  Google Scholar 

  • Sauver, J. L. S., Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2004). Early life risk factors for attention-deficit/hyperactivity disorder: A population-based cohort study. Mayo Clinical Proceedings, 79, 1124–1131.

    Google Scholar 

  • Schopler, E., Van Bourgondien, M., Wellman, J., & Love, S. (2010). Childhood autism rating scale—Second edition (CARS2): Manual. Los Angeles, CA: Western Psychological Services.

    Google Scholar 

  • Sciberras, E., Mueller, K. L., Efron, D., Bisset, M., Anderson, V., Schilpzand, E. J., … Nicholson, J. M. (2014). Language problems in children with ADHD: A community-based study. Pediatrics. doi:10.1542/peds.2013-3355

  • Sciberras, E., Ohan, J., & Anderson, V. (2012). Bullying and peer victimisation in adolescent girls with attention-deficit/hyperactivity disorder. Child Psychiatry and Human Development, 43, 254–270.

    PubMed  Google Scholar 

  • Sciberras, E., Roos, L., & Efron, D. (2009). Review of prospective longitudinal studies of children with ADHD: Mental health, educational, and social outcomes. Current Attention Disorder Reports, 1, 171–177.

    Google Scholar 

  • Sciberras, E., Ukoumunne, O., & Efron, D. (2011). Predictors of parent-reported attention-deficit/hyperactivity disorder in children aged 6-7 years: A National Longitudinal Study. Journal of Abnormal Child Psychology, 39, 1025–1034.

    PubMed  Google Scholar 

  • Siegel, D. J., Minshew, N. J., & Goldstein, G. (1996). Wechsler IQ profiles in diagnosis of high-functioning autism. Journal of Autism and Developmental Disorders, 26(4), 389–406.

    PubMed  Google Scholar 

  • Sikora, D. M., Hartley, S. L., McCoy, R., Gerrard-Morris, A. E., & Dill, K. (2008). The performance of children with mental health disorders on the ADOS-G: A question of diagnostic utility. Research in Autism Spectrum Disorders, 2(1), 188–197.

    Google Scholar 

  • Silk, T., Vance, A., Rinehart, N., Egan, G., O’Boyle, M., Bradshaw, J. L., Cunnington, R.. (2005). Decreased fronto-parietal activation in Attention Deficit Hyperactivity Disorder, combined type (ADHD-CT): An fMRI study. British Journal of Psychiatry, 187, 282–283.

    Google Scholar 

  • Silva, D., Colvin, L., Glauert, R., & Bower, C. (2014). Contact with the juvenile justice system in children treated with stimulant medication for attention deficit hyperactivity disorder: A population study. Lancet Psychiatry, 1, 278–285.

    PubMed  Google Scholar 

  • Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929. doi:10.1097/CHI.0b013e318179964f.

    Article  PubMed  Google Scholar 

  • Sinzig, J., Bruning, N., Morsch, D., & Lehmkuhl, G. (2008). Attention profiles in autistic children with and without comorbid hyperactivity and attention problems. Acta Neuropsychiatrica, 20(4), 207–215.

    PubMed  Google Scholar 

  • Sinzig, J., Morsch, D., Bruning, N., Schmidt, M. H., & Lehmkuhl, G. (2008). Inhibition, flexibility, working memory and planning in autism spectrum disorders with and without comorbid ADHD-symptoms. Child and Adolescent Psychiatry and Mental Health, 2, 4. doi:10.1186/1753-2000-2-4.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sinzig, J., Morsch, D., & Lehmkuhl, G. (2008). Do hyperactivity, impulsivity and inattention have an impact on the ability of facial affect recognition in children with autism and ADHD? European Child & Adolescent Psychiatry, 17(2), 63–72.

    Google Scholar 

  • Sinzig, J., Walter, D., & Doepfner, M. (2009). Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: Symptom or syndrome? Journal of Attention Disorders, 13(2), 117–126. doi:10.1177/1087054708326261.

    Article  PubMed  Google Scholar 

  • Sizoo, B. B., van den Brink, W., Gorissen-van Eenige, M., Koeter, M. W., van Wijngaarden-Cremers, P. J., & van der Gaag, R. J. (2009). Using the autism-spectrum quotient to discriminate autism spectrum disorder from ADHD in adult patients with and without comorbid substance use disorder. Journal of Autism and Developmental Disorders, 39(9), 1291–1297.

    PubMed  PubMed Central  Google Scholar 

  • Sonuga-Barke, E. J. S., Brandeis, D., Cortese, S., Daley, D., Ferrin, M., Holtmann, M., … European ADHD Guidelines Group. (2013). Nonpharmacological interventions for ADHD: Systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. American Journal of Psychiatry, 170, 275–289.

    Google Scholar 

  • Sowell, E. R., Thompson, P. M., Welcome, S. E., Henkenius, A. L., Toga, A. W., & Peterson, B. S. (2003). Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. Lancet, 362, 1699–1707.

    PubMed  Google Scholar 

  • Spencer, T. J., Faraone, S. V., Biederman, J., Lerner, M., Cooper, K. M., Zimmerman, B., & Concerta Study Group. (2006). Does prolonged therapy with a long-acting stimulant suppress growth in children with ADHD? Journal of the American Academy of Child and Adolescent Psychiatry, 45(5), 527–537. doi:10.1097/01.chi.0000205710.01690.d4

  • Srebnicki, T., Kołakowski, A., & Wolańczyk, T. (2013). Adolescent outcome of child ADHD in primary care setting stability of diagnosis. Journal of Attention Disorders, 17(8), 655–659.

    PubMed  Google Scholar 

  • Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23(4), 289–299.

    PubMed  Google Scholar 

  • Stein, M. A., Szumowski, E., Blondis, T. A., & Roizen, N. J. (1995). Adaptive skills dysfunction in ADD and ADHD children. Journal of Child Psychology and Psychiatry, 36(4), 663–670. doi:10.1111/j.1469-7610.1995.tb02320.x.

    Article  PubMed  Google Scholar 

  • Sung, V., Hiscock, H., Sciberras, E., & Efron, D. (2008). Sleep problems in children with attention-deficit/hyperactivity disorder—Prevalence and the effect on the child and family. Archives of Pediatrics & Adolescent Medicine, 162, 336–342.

    Google Scholar 

  • Tarver, J., Daley, D., & Sayal, K. (2014). Attention-deficit hyperactivity disorder (ADHD): An updated review of the essential facts. Child: Care, Health and Development, 40(6), 762–774. doi:10.1111/cch.12139.

    Article  PubMed  Google Scholar 

  • Taurines, R., Schwenck, C., Westerwald, E., Sachse, M., Siniatchkin, M., & Freitag, C. (2012). ADHD and autism: Differential diagnosis or overlapping traits? A selective review. ADHD Attention Deficit and Hyperactivity Disorders, 4(3), 115–139.

    PubMed  Google Scholar 

  • Taylor, E., Döpfner, M., Sergeant, J., Asherson, P., Banaschewski, T., Buitelaar, J., … Zuddas, A. (2004). European clinical guidelines for hyperkinetic disorder—First upgrade. European Child & Adolescent Psychiatry, 13(1), i7–i30. doi:10.1007/s00787-004-1002-x

  • Thapar, A., Cooper, M., Jefferies, R., & Stergiakouli, E. (2012). What causes attention deficit hyperactivity disorder? Archives of Disease in Childhood, 97, 260–265.

    PubMed  Google Scholar 

  • The MTA Cooperative Group. (1999). A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 56, 1073–1086.

    Google Scholar 

  • Tonge, B., & Rinehart, N. (2007). Autism and attention deficit/hyperactivity disorder. In A. H. V. Schapira (Ed.), Neurology and clinical neuroscience (pp. 129–139). Philadelphia, PA: Mosby Inc Elsevier.

    Google Scholar 

  • Tripp, G., & Wickens, J. R. (2005). Neurobiology of ADHD. Neuropharmacology, 57, 579–589.

    Google Scholar 

  • Tripp, G., & Wickens, J. R. (2009). Neurobiology of ADHD. Neuropharmacology, 57(7–8), 579–589. doi:10.1016/j.neuropharm.2009.07.026.

    Article  PubMed  Google Scholar 

  • Wilens, T. E., Biederman, J., Brown, S., Tanguay, S., Monuteaux, M. C., Blake, C., & Spencer, T. J. (2002). Psychiatric comorbidity and functioning in clinically referred preschool children and school-age youths with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 41(3), 262–268. doi:10.1097/00004583-200203000-00005

  • Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57(11), 1336–1346. doi:10.1016/j.biopsych.2005.02.006.

    Article  PubMed  Google Scholar 

  • Willcutt, E. G., Nigg, J. T., Pennington, B. F., Solanto, M. V., Rohde, L. A., Tannock, R., … Lahey, B. B. (2012). Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. Journal of Abnormal Psychology, 121, 991–1010.

    Google Scholar 

  • Williams, N. M., Zaharieva, I., Martin, A., Langley, K., Mantripragada, K., Fossdal, R., … Thapar, A. (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: A genome-wide analysis. Lancet, 376(9750), 1401–1408. doi:10.1016/s0140-6736(10)61109-9

  • Wolraich, M., Brown, L., Brown, R., DuPaul, G., Earls, M., Feldman, H., … Perrin, J. (2011). Subcommittee on Attention-Deficit/Hyperactivity Disorder; Steering Committee on Quality Improvement and Management. ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 128(5), 1007–1022.

    Google Scholar 

  • Yerys, B. E., Wallace, G. L., Sokoloff, J. L., Shook, D. A., James, J. D., & Kenworthy, L. (2009). Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders. Autism Research, 2(6), 322–333.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia

    Tamara May

  2. Deakin Child Study Centre, School of Psychology, Deakin University, Burwood, VIC, Australia

    Emma Sciberras & Nicole Rinehart

  3. Murdoch Childrens Research Institute, Parkville, VIC, Australia

    Emma Sciberras & Harriet Hiscock

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  1. Department of Psychology, Louisiana State University, Baton Rouge, LA, USA

    Johnny L. Matson

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May, T., Sciberras, E., Hiscock, H., Rinehart, N. (2016). The Comorbid Diagnosis of ASD and ADHD: Clinical and Neuropsychological Perspectives. In: Matson, J.L. (eds) Handbook of Assessment and Diagnosis of Autism Spectrum Disorder. Autism and Child Psychopathology Series. Springer, Cham. https://doi.org/10.1007/978-3-319-27171-2_14

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